PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PROC	1	PROCR	0	pull down	Liaw PC (2000)	1
PROC	1	WNT5A	1	affinity chromatography technology	Huttlin EL (2017)	1
PROC	1	PROS1	3	affinity chromatography technology	Huttlin EL (2017)	1
CSNK2B	5	PROC	1	two hybrid	Vinayagam A (2011)	1
PF4	0	PROC	1	pull down	Dudek AZ (1997)	1
NPB	0	PROC	1	affinity chromatography technology	Huttlin EL (2017)	1
TK1	0	PROC	1	two hybrid	Vinayagam A (2011)	1
PROC	1	EPHA6	0	affinity chromatography technology	Huttlin EL (2017)	1
PROC	1	UQCRH	0	affinity chromatography technology	Huttlin EL (2017)	1
PROC	1	PDF	0	affinity chromatography technology	Huttlin EL (2017)	1
SERPINA5	3	PROC	1	pull down, biochemical	Espana F (1989), Strandberg K (2000)	2