PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAF1	0	KIAA1217	7	two hybrid	Rolland T (2014)	1
KIAA1217	7	GCC1	1	two hybrid	Rual JF (2005)	1
HNRNPL	3	KIAA1217	7	affinity chromatography technology	Fei T (2017)	1
EGFR	5	KIAA1217	7	affinity chromatography technology	Yao Z (2017)	1
HSBP1	0	KIAA1217	7	two hybrid	Rolland T (2014)	1
XPO1	8	CNTROB	6	affinity chromatography technology	Kirli K (2015)	1
KIAA1217	7	HNRNPLL	1	biochemical	Wan C (2015)	1
CDH1	4	GOLGA2	2	bioid	Guo Z (2014)	1
NCK2	2	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Chen M (1998), Braverman LE (1999), Tu Y (1998), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	6
NCK2	2	KIAA1217	7	two hybrid	Rual JF (2005)	1
XPO1	8	VPS52	0	affinity chromatography technology	Kirli K (2015)	1
SEC16A	7	KIAA1217	7	affinity chromatography technology	Hein MY (2015)	1
NCK2	2	WASF3	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
XPO1	8	GOLGA2	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	KIAA1217	7	affinity chromatography technology	Kirli K (2015)	1
FHL2	0	KIAA1217	7	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
MICU2	2	KIAA1217	7	affinity chromatography technology	Huttlin EL (2015)	1
GOLGA2	2	GCC1	1	two hybrid	Rolland T (2014)	1
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
NCK2	2	FXR2	2	two hybrid	Rual JF (2005)	1
WASF3	3	KIAA1217	7	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	NCK2	2	affinity chromatography technology	Fei T (2017)	1
XPO1	8	EXOSC5	0	affinity chromatography technology	Kirli K (2015)	1
VPS52	0	KIAA1217	7	two hybrid	Rolland T (2014)	1
ABI2	4	KIAA1217	7	two hybrid	Rolland T (2014)	1
TRIB2	2	KIAA1217	7	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	WASF3	3	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
ABI2	4	WASF3	3	affinity chromatography technology	Huttlin EL (2017)	1
HNRNPL	3	WASF3	3	affinity chromatography technology	Fei T (2017)	1
GOLGA2	2	EXOSC5	0	two hybrid	Rolland T (2014)	1
ABI2	4	GCC1	1	two hybrid	Rolland T (2014)	1
KIAA1217	7	EXOSC5	0	two hybrid	Rual JF (2005)	1
SORBS3	5	KIAA1217	7	two hybrid	Rual JF (2005)	1
CDH1	4	EGFR	5	affinity chromatography technology, two hybrid, imaging technique, protein complementation assay, affinity chromatography technology, bioid	Pece S (2000), Kotlyar M (2015), Chen TC (2014), Petschnigg J (2014), Li J (2013), Guo Z (2014)	6
TEX11	0	KIAA1217	7	two hybrid	Rual JF (2005)	1
KIAA1217	7	NARS	3	biochemical	Wan C (2015)	1
HNRNPL	3	NARS	3	biochemical	Wan C (2015)	1
CDH1	4	KIAA1217	7	bioid	Guo Z (2014)	1
CNTROB	6	KIAA1217	7	bioid	Gupta GD (2015)	1
EGFR	5	XPO1	8	affinity chromatography technology	Foerster S (2013)	1
NCK2	2	ABI2	4	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Rolland T (2014), Huttlin EL (2015), Huttlin EL (2017)	4
RMND5A	0	KIAA1217	7	affinity chromatography technology	Lampert F (2018)	1
SEC16A	7	GOLGA2	2	affinity chromatography technology	Hein MY (2015)	1
SHMT2	3	ABI2	4	affinity chromatography technology	Castello A (2012)	1
SIAH1	2	KIAA1217	7	two hybrid	Rolland T (2014)	1
FXR2	2	KIAA1217	7	two hybrid	Rual JF (2005)	1
EGFR	5	SEC16A	7	affinity chromatography technology	Yao Z (2017)	1
KRT15	2	ABI2	4	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
KRT15	2	KIAA1217	7	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
GOLGA2	2	KIAA1217	7	two hybrid	Rolland T (2014)	1
SHMT2	3	KIAA1217	7	affinity chromatography technology	Castello A (2012)	1
CDH1	4	NCK2	2	bioid	Guo Z (2014)	1
NINL	1	KIAA1217	7	bioid	Gupta GD (2015)	1
NINL	1	GCC1	1	two hybrid	Rual JF (2005)	1
XPO1	8	SEC16A	7	affinity chromatography technology	Kirli K (2015)	1