PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
ESRRA	2	PROX1	0	two hybrid	Albers M (2005)	1
PAX6	3	EP300	36	pull down, affinity chromatography technology, affinity chromatography technology	Hussain MA (1999), Hussain MA (1999), Hussain MA (1999)	3
HNF4A	2	PROX1	0	two hybrid	Albers M (2005)	1
PAX6	3	PROX1	0	pull down	Mikkola I (2001)	1
EP300	36	RORA	4	two hybrid, pull down	Lau P (1999), Lau P (1999)	2
NTRK1	1	PROX1	0	affinity chromatography technology	Emdal KB (2015)	1
HNF4A	2	SMAD3	1	affinity chromatography technology, pull down	Kardassis D (2000), Kardassis D (2000)	2
RORA	4	PROX1	0	two hybrid	Albers M (2005)	1
GIT2	2	SMAD3	1	two hybrid	Wang J (2011)	1
CTBP2	7	PROX1	0	affinity chromatography technology, two hybrid	Wang J (2011), Wang J (2011)	2
PROX1	0	SMAD3	1	two hybrid	Wang J (2011)	1
EP300	36	HDAC3	5	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Kadeppagari RK (2009), Gregoire S (2007), Gregoire S (2007), Sankar N (2008), Sankar N (2008)	5
GIT2	2	PROX1	0	two hybrid	Wang J (2011)	1
NR3C2	4	EP300	36	affinity chromatography technology	Seo M (2015)	1
SMAD3	1	PAX6	3	affinity chromatography technology	Grocott T (2007)	1
SMAD3	1	ZBTB3	3	two hybrid	Ravasi T (2010)	1
PPARD	4	PROX1	0	two hybrid	Albers M (2005)	1
IRF4	1	PROX1	0	two hybrid	Ravasi T (2010)	1
PROX1	0	EP300	36	two hybrid, affinity chromatography technology	Chen Q (2002), Chen Q (2002)	2
NR3C2	4	PROX1	0	two hybrid	Albers M (2005)	1
ESRRA	2	ESRRG	2	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, two hybrid, imaging technique	Zhang Z (2007), Zhang Z (2007), Dufour CR (2007), Albers M (2005), Albers M (2005), Wang L (2008)	6
PROX1	0	HDAC3	5	affinity chromatography technology	Shan SF (2008)	1
PPARD	4	HDAC3	5	pull down, affinity chromatography technology	Franco PJ (2003), Shi Y (2002)	2
PPARD	4	EP300	36	pull down, two hybrid	Cho MC (2006), Mochizuki K (2008)	2
HDAC3	5	HNF4A	2	pull down	Torres-Padilla ME (2002)	1
ESRRG	2	PROX1	0	two hybrid	Albers M (2005)	1
CTBP2	7	EP300	36	affinity chromatography technology	Zhao LJ (2009)	1
LBH	0	PROX1	0	two hybrid	Wang J (2011)	1
PROX1	0	ZBTB3	3	two hybrid	Ravasi T (2010)	1