PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ERBB3	3	CDC37	0	affinity chromatography technology	Li J (2013)	1
MASP1	3	PDCD6IP	3	affinity chromatography technology	Schmidt MH (2003)	1
CDC37	0	RPS6KA3	2	affinity chromatography technology	Li J (2013)	1
MBL2	0	MASP1	3	affinity chromatography technology	Thiel S (2000)	1
GSK3B	1	MASP1	3	two hybrid	Vinayagam A (2011)	1
RPS6KA6	0	MASP1	3	two hybrid	Vinayagam A (2011)	1
ERRFI1	1	MASP1	3	affinity chromatography technology	Li J (2013)	1
CUL3	17	MASP1	3	affinity chromatography technology	Bennett EJ (2010)	1
CDC37	0	MASP1	3	affinity chromatography technology	Li J (2013)	1
UFD1	1	MASP1	3	two hybrid	Vinayagam A (2011)	1
MASP1	3	FCN2	2	pull down	Cseh S (2002)	1
RPS6KA3	2	MASP1	3	two hybrid	Vinayagam A (2011)	1
CUL3	17	AP2M1	5	affinity chromatography technology	Bennett EJ (2010)	1
MAPK6	1	PDCD6IP	3	two hybrid	Vinayagam A (2011)	1
RPS6KA3	2	H2AFX	1	enzymatic study	Zhu F (2011)	1
NCK2	2	MASP1	3	two hybrid	Vinayagam A (2011)	1
NUDT21	0	MASP1	3	two hybrid	Vinayagam A (2011)	1
SERPING1	2	MASP1	3	pull down	Matsushita M (2000)	1
SERPING1	2	MASP2	4	pull down	Matsushita M (2000)	1
CDK19	1	MASP1	3	affinity chromatography technology	Varjosalo M (2013)	1
MAPK6	1	MASP1	3	two hybrid	Vinayagam A (2011)	1
H2AFX	1	MASP1	3	two hybrid	Vinayagam A (2011)	1
MBL2	0	MASP2	4	affinity chromatography technology	Thiel S (2000)	1
GADD45A	1	MASP1	3	two hybrid	Vinayagam A (2011)	1
MAPK8IP2	5	MASP1	3	two hybrid	Vinayagam A (2011)	1
CUL3	17	PDCD6IP	3	affinity chromatography technology	Bennett EJ (2010)	1
CDC37	0	RPS6KA6	0	biochemical, affinity chromatography technology	Havugimana PC (2012), Li J (2013)	2
MASP1	3	MASP2	4	affinity chromatography technology	Thiel S (2000)	1
NCK2	2	ERBB3	3	unspecified method	Jones RB (2006)	1
AP2M1	5	MASP1	3	affinity chromatography technology	Li J (2013)	1
MASP2	4	FCN2	2	pull down	Cseh S (2002)	1
ERBB3	3	MASP1	3	affinity chromatography technology	Li J (2013)	1
CUL3	17	NUDT21	0	affinity chromatography technology	Bennett EJ (2010)	1