PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PSEN2	3	CIB1	2	two hybrid, pull down, genetic interference, affinity chromatography technology	Stabler SM (1999), Stabler SM (1999), Stabler SM (1999), Stabler SM (1999)	4
PSEN2	3	PDCD4	2	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN1	11	APH1A	2	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baulac S (2003), Baulac S (2003), Gu Y (2003), Gu Y (2003), Gu Y (2003), Lee SF (2002), Hebert SS (2004), Hebert SS (2004), Sato T (2007), Kuo LH (2008)	10
PSEN2	3	FLNB	11	two hybrid, pull down	Zhang W (1998), Zhang W (1998)	2
CDH1	4	KANK2	4	bioid	Guo Z (2014)	1
CDH1	4	EPB41L3	5	bioid	Guo Z (2014)	1
UBQLN1	1	APP	1	two hybrid, affinity chromatography technology, fluorescent resonance energy transfe	Stieren ES (2011), Stieren ES (2011), Hiltunen M (2006)	3
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
UBQLN1	1	UNK	3	biochemical	Havugimana PC (2012)	1
CDH1	4	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Kinch MS (1995), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Schmeiser K (1999), Catimel B (2005), Guo Z (2014)	7
APP	1	PSEN1	11	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
TRAF6	0	IRAK2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Muzio M (1997), Keating SE (2007), Li S (2011), Li S (2011), Wang J (2011), Wang H (2015), Huttlin EL (2017)	8
PKP4	5	DSP	8	two hybrid	Hatzfeld M (2003)	1
PSEN2	3	KCNIP4	0	two hybrid, affinity chromatography technology	Morohashi Y (2002), Morohashi Y (2002)	2
CDC37	0	APP	1	two hybrid	Soler-Lopez M (2011)	1
NDUFS8	0	PSEN1	11	biochemical	Havugimana PC (2012)	1
PSEN1	11	CTNND1	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Tanahashi H (1999), Tanahashi H (1999), Tanahashi H (1999), Shrestha H (2017)	4
CDC37	0	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
UBC	7	DHX9	3	affinity chromatography technology	Matsumoto M (2005)	1
UBC	7	CDH2	4	pull down	Nathan JA (2013)	1
PSEN1	11	CDH2	4	affinity chromatography technology	Maesako M (2010)	1
PSEN1	11	ETFA	0	two hybrid	Van Gassen G (1999)	1
PSEN1	11	ITSN2	7	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	CDK5	0	two hybrid	Soler-Lopez M (2011)	1
ACTN1	5	CTNNA1	7	affinity chromatography technology, imaging technique	Knudsen KA (1995), Chen TC (2014)	2
PSEN1	11	TDP2	2	two hybrid	Wang J (2011)	1
GFAP	0	APP	1	pull down	Olah J (2011)	1
APP	1	GSK3B	1	affinity chromatography technology, affinity chromatography technology, pull down	Zhou F (2012), Zhou F (2012), Olah J (2011)	3
APP	1	MAPT	1	pull down, unspecified method	Guo JP (2006), Guo JP (2006)	2
CTNNB1	30	DHX9	3	affinity chromatography technology	Sato S (2005)	1
PSEN1	11	PSENEN	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baulac S (2003), Baulac S (2003), Crystal AS (2003), Steiner H (2002), Hebert SS (2004), Yonemura Y (2011)	6
NCSTN	1	ERLIN2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Teranishi Y (2012), Teranishi Y (2012), Hein MY (2015)	3
APOE	1	ST13	2	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
APOE	1	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
PRDX2	1	APP	1	pull down	Olah J (2011)	1
UBC	7	NDUFS8	0	pull down	Zhang X (2017)	1
ERN1	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Qiu Q (2013), Qiu Q (2013)	2
PSEN1	11	FGF13	0	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	MAPT	1	biochemical	Takashima A (1998)	1
PSEN1	11	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tesco G (1998), Kang DE (1999), Murayama M (1998), Prager K (2007), Prager K (2007), Prager K (2007), Serban G (2005), Raurell I (2006), Raurell I (2006)	9
RAD23A	1	UBC	7	pull down, pull down, x-ray crystallography, pull down, x-ray crystallography, affinity chromatography technology, pull down, pull down, unspecified method, pull down, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, x-ray crystallography, pull down, pull down	Kang Y (2006), Sims JJ (2009), Kang Y (2007), Kang Y (2007), Wang Q (2003), Scanlon TC (2009), Raasi S (2003), Sokratous K (2012), Varadan R (2005), Fenner BJ (2009), Raasi S (2005), Massey LK (2004), Chen L (2006), Nathan JA (2013), Nathan JA (2013), Jung J (2014), Goh AM (2008), Castaneda CA (2013), Nakasone MA (2013), Lai MY (2012), Kristariyanto YA (2015), Zhang X (2017)	22
APOE	1	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	OXCT1	1	two hybrid	Soler-Lopez M (2011)	1
NCSTN	1	APP	1	affinity chromatography technology	Yu G (2000)	1
PSEN2	3	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
HERPUD1	2	UBQLN1	1	affinity chromatography technology, affinity chromatography technology	Kim TY (2008), Kim TY (2008)	2
PSEN1	11	CDC37	0	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
UNK	3	PDCD4	2	affinity chromatography technology	Murn J (2015)	1
RNF32	0	APOE	1	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
GSK3B	1	EPB41L3	5	affinity chromatography technology	Varjosalo M (2013)	1
PSEN1	11	NOTCH1	25	affinity chromatography technology	Ray WJ (1999)	1
PSEN1	11	NOS3	7	two hybrid	Soler-Lopez M (2011)	1
KRAS	1	FBXW7	2	genetic interference	Luo J (2009)	1
ECSIT	3	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
CTNNA1	7	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
GSAP	3	NCSTN	1	affinity chromatography technology	He G (2010)	1
PSEN1	11	ERLIN2	2	affinity chromatography technology, affinity chromatography technology	Teranishi Y (2012), Teranishi Y (2012)	2
PSEN1	11	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
PSMA5	0	UBQLN1	1	biochemical	Havugimana PC (2012)	1
RNF32	0	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	EPB41L3	5	two hybrid	Soler-Lopez M (2011)	1
FBXW7	2	GSK3B	1	affinity chromatography technology	Kwon YW (2012)	1
RAD23A	1	UBQLN1	1	x-ray crystallography, affinity chromatography technology, biochemical	Kang Y (2007), Kang Y (2007), Wan C (2015)	3
PSEN1	11	SCN1A	54	two hybrid	Soler-Lopez M (2011)	1
APH1A	2	ERLIN2	2	affinity chromatography technology, affinity chromatography technology	Teranishi Y (2012), Teranishi Y (2012)	2
PSEN1	11	ENSA	0	two hybrid	Soler-Lopez M (2011)	1
PSEN2	3	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PSEN1	11	two hybrid	Soler-Lopez M (2011)	1
UNK	3	PSEN1	11	affinity chromatography technology	Murn J (2015)	1
GSK3B	1	PSEN1	11	enzymatic study	Prager K (2007)	1
PSEN1	11	PSEN2	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Gu Y (2003), Soler-Lopez M (2011), Hebert SS (2004), Hebert SS (2004)	4
APP	1	CFL1	0	two hybrid	Soler-Lopez M (2011)	1
TCF7L2	12	PSEN1	11	affinity chromatography technology	Palacino JJ (2001)	1
PSEN2	3	ICAM5	0	pull down	Annaert WG (2001)	1
UBC	7	ITSN2	7	pull down	Zhang X (2017)	1
MAPT	1	TUBA1B	0	pull down	Flach K (2014)	1
CTNND1	4	GSK3B	1	affinity chromatography technology, affinity chromatography technology	Shrestha H (2017), Shrestha H (2017)	2
CTNNB1	30	CTNND1	4	affinity chromatography technology, affinity chromatography technology	Hazan RB (1998), Kucerova D (2001)	2
NOS3	7	APP	1	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
ECSIT	3	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
CDH8	2	PKP4	5	affinity chromatography technology	Huttlin EL (2017)	1
APOE	1	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
CDH2	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Straub BK (2003), Wahl JK (2003), Fischer L (2002), Sadot E (2002), Chung FZ (2014), Boscher C (2008)	6
RNF32	0	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
APH1B	0	NCSTN	1	affinity chromatography technology	Hebert SS (2004)	1
PSEN1	11	HMGB1	0	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	KANK2	4	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
APOE	1	NOS3	7	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN1	11	BCL2	0	two hybrid, affinity chromatography technology	Alberici A (1999), Alberici A (1999)	2
CDC37	0	CDK5	0	two hybrid	Soler-Lopez M (2011)	1
TCF7L2	12	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lukas J (2009), Idogawa M (2007), Hong CF (2009), Del Valle-Perez B (2011), Tzeng SL (2006), Tzeng SL (2006), Satow R (2012), Satow R (2012), Graham TA (2001), Sato S (2005), Mosimann C (2006), Shekhar MP (2006), Hsu MC (2007), Loregger A (2015), Hanson AJ (2012), Kuslansky Y (2016)	16
CDC37	0	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
AP1M2	2	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
CTNNB1	30	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davies G (2001), Kishida S (1999), Fischer L (2002), Kitagawa M (1999), Hart M (1999), Su Y (2008), Huang X (2009), Ding Q (2005), Piao S (2008), Varjosalo M (2013), Gao C (2014), Koo J (2015), Chen TC (2014), Lu D (2012), Kuslansky Y (2016), Novellasdemunt L (2017), Lu WJ (2015)	17
PSEN1	11	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
CDK5	0	MAPT	1	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Sengupta A (1998), Liu F (2002), Paudel HK (1997), Sasaki K (2009), Liu F (2006)	5
TRAF6	0	TDP2	2	affinity chromatography technology	Pype S (2000)	1
NCSTN	1	PSEN2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee SF (2002), Yu G (2000), Hebert SS (2004)	3
DTNA	4	PSEN1	11	biochemical	Havugimana PC (2012)	1
PSEN1	11	KANK2	4	two hybrid	Soler-Lopez M (2011)	1
BCL2L1	0	BCL2	0	unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhang H (2002), Lin B (2004), Kolluri SK (2008), Huttlin EL (2015), Huttlin EL (2017)	5
PSEN1	11	RMDN3	1	two hybrid	Soler-Lopez M (2011)	1
UBC	7	ERLIN2	2	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Jo Y (2011)	2
PSEN1	11	TCF4	26	affinity chromatography technology, pull down	Raurell I (2006), Raurell I (2006)	2
APOE	1	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
DHX9	3	PSEN1	11	biochemical	Havugimana PC (2012)	1
CTNNB1	30	MAPK9	3	affinity chromatography technology, affinity chromatography technology, enzymatic study	Lee MH (2009), Lee MH (2009), Lee MH (2009)	3
GSK3B	1	GAPDH	0	two hybrid	Vinayagam A (2011)	1
GCDH	2	NOS3	7	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
GSAP	3	APP	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, protein complementation assay	He G (2010), He G (2010), He G (2010), Savolainen MH (2015)	4
ECSIT	3	RAD23A	1	two hybrid	Soler-Lopez M (2011)	1
RAD23A	1	PSMA5	0	affinity chromatography technology	Scanlon TC (2009)	1
CDK5	0	APP	1	pull down	Olah J (2011)	1
KCNIP4	0	APP	1	pull down	Olah J (2011)	1
FBXW7	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Jiang JX (2016), Jiang JX (2016)	2
HERPUD1	2	APP	1	pull down	Olah J (2011)	1
ECSIT	3	APP	1	two hybrid	Soler-Lopez M (2011)	1
GSK3B	1	CDH1	4	imaging technique	Chen TC (2014)	1
APH1B	0	PSENEN	3	affinity chromatography technology	Hebert SS (2004)	1
CDH2	4	CTNND1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Straub BK (2003), Wahl JK (2003), Ishiyama N (2010)	3
GSK3B	1	BCL2L1	0	enzymatic study	Wang J (2012)	1
PSEN1	11	ICAM5	0	affinity chromatography technology, two hybrid, pull down	Annaert WG (2001), Annaert WG (2001), Annaert WG (2001)	3
NCSTN	1	PSEN1	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Haffner C (2004), Baulac S (2003), Baulac S (2003), Gu Y (2003), Gu Y (2003), Lee SF (2002), Yu G (2000), Hebert SS (2004), Sato T (2007), Sato T (2007), Kuo LH (2008)	11
KRAS	1	PSMA5	0	genetic interference	Luo J (2009)	1
CDH1	4	NOTCH1	25	bioid	Guo Z (2014)	1
GSK3B	1	MAPT	1	enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Shimura H (2004), Wang JZ (1998), Richet E (2012), Richet E (2012), Schneider A (1999), Kawakami F (2011), Kawakami F (2011), Zheng-Fischhoefer Q (1998), Virdee K (2007), Liu F (2002), Sadik G (2009), Sasaki K (2009), Liu F (2006), Watcharasit P (2002)	14
PSEN1	11	BCL2L1	0	two hybrid	Passer BJ (1999)	1
NCSTN	1	PSENEN	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baulac S (2003), Baulac S (2003), Steiner H (2002), Yonemura Y (2011), Kuo LH (2008)	5
TRAF6	0	PSEN2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Elzinga BM (2009), Yan R (2013), Yan R (2013)	3
IRAK2	3	CDC37	0	affinity chromatography technology	Li S (2011)	1
KCNIP3	1	PSEN1	11	affinity chromatography technology, affinity chromatography technology	Buxbaum JD (1998), Kashiwa A (2000)	2
PSEN1	11	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	PKP4	5	affinity chromatography technology, pull down, two hybrid	Stahl B (1999), Stahl B (1999), Stahl B (1999)	3
TGFBR1	2	NOTCH1	25	affinity chromatography technology, affinity chromatography technology	Gudey SK (2014), Gudey SK (2014)	2
TRAF6	0	KRAS	1	affinity chromatography technology	Han Q (2014)	1
GSAP	3	PSEN1	11	affinity chromatography technology	He G (2010)	1
APH1B	0	PSEN2	3	affinity chromatography technology	Hebert SS (2004)	1
CDH1	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Davies G (2001), Kucerova D (2001), Oyama T (1994), Hazan RB (1997), Kinch MS (1995), Jiang MC (2002), Hazan RB (1998), Bonvini P (2001), Li Y (1998), Wendeler MW (2004), Shibata T (2003), Piedra J (2003), Oneyama C (2002), Navarro P (1993), Takahashi K (1997), Dobrosotskaya IY (2000), Dobrosotskaya IY (2000), Geng L (2000), Shibamoto S (1995), Rao RK (2002), Rao RK (2002), Huber AH (2001), Schmeiser K (1999), Pai R (2008), Tu LC (2007), Tu LC (2007), Smyth D (2012), Xue B (2005), Xue B (2005), Catimel B (2005), Huang Z (2012), Yan HX (2006), Yan HX (2006), Figueiredo J (2013), Ponce E (2014), Ponce E (2014), Ponce E (2014), Ribeiro AS (2013), Pinheiro H (2012), Geng F (2012), Lee HK (2007), Guo Z (2014)	42
ECSIT	3	PSEN2	3	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PKP4	5	CDH2	4	two hybrid	Hatzfeld M (2003)	1
PSEN1	11	EFHD1	1	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	CYP2C8	3	two hybrid	Soler-Lopez M (2011)	1
KRAS	1	APP	1	pull down	Olah J (2011)	1
CDH8	2	CTNND1	4	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	MAPT	1	enzymatic study	Babu JR (2005)	1
PSEN2	3	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	HERPUD1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sai X (2002), Sai X (2003), Sai X (2003)	3
PSEN1	11	STAMBPL1	2	two hybrid	Soler-Lopez M (2011)	1
NOS3	7	CDC37	0	affinity chromatography technology, two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
RNF32	0	FBXL12	1	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN1	11	CTNNA1	7	affinity chromatography technology	Georgakopoulos A (1999)	1
NOS3	7	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
ACTN1	5	ECSIT	3	biochemical	Wan C (2015)	1
TRAF6	0	APP	1	pull down	Olah J (2011)	1
APH1A	2	PSEN2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gu Y (2003), Lee SF (2002), Hebert SS (2004), Hebert SS (2004)	4
PSMA5	0	APP	1	pull down	Olah J (2011)	1
UBC	7	PSMA5	0	affinity chromatography technology	Matsumoto M (2005)	1
TCF4	26	STAMBPL1	2	two hybrid	Rolland T (2014)	1
PSEN1	11	ACTN1	5	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	FBXL12	1	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
GSK3B	1	NOTCH1	25	enzymatic study, pull down	Foltz DR (2002), Foltz DR (2002)	2
NOTCH1	25	FBXW7	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, protein complementation assay	Gupta-Rossi N (2001), Thompson BJ (2007), Thompson BJ (2007), ONeil J (2007), ONeil J (2007), Busino L (2012), Mo JS (2007), Kim MY (2011), Yatim A (2012), Yumimoto K (2013), Baek HJ (2015), Liu B (2015), Yeh CH (2016), Ahn JS (2016), Ahn JS (2016), Zhao J (2017), Zhao J (2017), Zhao J (2017), Daakour S (2016)	19
SPPL2B	0	PSEN1	11	affinity chromatography technology	Huttlin EL (2017)	1
PSEN1	11	UMPS	4	two hybrid	Soler-Lopez M (2011)	1
CYP2C8	3	APOE	1	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	RHEB	2	two hybrid	Soler-Lopez M (2011)	1
APP	1	FGF13	0	pull down	Virok DP (2011)	1
MAPK9	3	BCL2L1	0	enzymatic study	Wang J (2012)	1
PSEN1	11	PDCD4	2	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	APP	1	pull down, two hybrid, pull down	Olah J (2011), Soler-Lopez M (2011), Virok DP (2011)	3
ECSIT	3	PSEN1	11	two hybrid, affinity chromatography technology, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011), Soler-Lopez M (2011)	3
PSEN1	11	FBXW7	2	affinity chromatography technology	Li J (2002)	1
PSEN1	11	TUBA1B	0	two hybrid	Soler-Lopez M (2011)	1
MAPT	1	APOE	1	pull down, unspecified method	Fleming LM (1996), Huang DY (1995)	2
PSEN1	11	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, imaging technique	Gudey SK (2014), Gudey SK (2014), Gudey SK (2014)	3
NCSTN	1	APH1A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Haffner C (2004), Baulac S (2003), Baulac S (2003), LaVoie MJ (2003), Gu Y (2003), Gu Y (2003), Gu Y (2003), Lee SF (2002), Lee SF (2002), Hebert SS (2004), Suzuki Y (2009), Sato T (2007), Kuo LH (2008), Kuo LH (2008)	14
APOE	1	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
CDH1	4	CTNND1	4	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, bioid	Daniel JM (1995), Daniel JM (1995), Ireton RC (2002), Kinch MS (1995), Hazan RB (1998), Bonne S (2003), Piedra J (2003), Piedra J (2003), Shibamoto S (1995), Shibamoto S (1995), Ohkubo T (1999), Ohkubo T (1999), Ishiyama N (2010), Ishiyama N (2010), Ishiyama N (2010), Chen Y (2009), Smyth D (2012), Del Valle-Perez B (2011), Figueiredo J (2013), Ribeiro AS (2013), Pinheiro H (2012), Guo Z (2014)	22
CDH8	2	PSEN1	11	affinity chromatography technology	Huttlin EL (2017)	1
ECSIT	3	CYP2C18	2	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	CYP2C18	2	two hybrid	Soler-Lopez M (2011)	1
HMGB1	0	GFAP	0	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	TGFBR1	2	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, imaging technique	Sorrentino A (2008), Yamashita M (2008), Yamashita M (2008), Yamashita M (2008), Zhang J (2014), Cao Q (2016), Sundar R (2015), Sundar R (2015), Sundar R (2015)	9
CLSTN1	0	APP	1	affinity chromatography technology, affinity chromatography technology	Araki Y (2004), Araki Y (2003)	2
PSEN1	11	CDK5	0	two hybrid	Soler-Lopez M (2011)	1
GAPDH	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PSEN1	11	GFAP	0	two hybrid, pull down	Nielsen AL (2002), Nielsen AL (2002)	2
CTNNB1	30	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Oyama T (1994), Roe S (1998), Piedra J (2003), Aberle H (1994), Reuver SM (1998), Selbach M (2006), Tian Q (2004), Wan C (2015), Hein MY (2015), Ji H (2009), Ji H (2009)	11
UNK	3	YME1L1	2	affinity chromatography technology	Murn J (2015)	1
APP	1	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
UNK	3	CTNNA1	7	affinity chromatography technology	Murn J (2015)	1
PSEN1	11	PSMB1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Van Gassen G (1999), Van Gassen G (1999), Van Gassen G (1999), Van Gassen G (1999)	4
FBXW7	2	TUBA1B	0	genetic interference	Bailey ML (2015)	1
NOS3	7	ST13	2	affinity chromatography technology, two hybrid	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
CDH1	4	FLNB	11	bioid	Guo Z (2014)	1
MAPK9	3	PSEN1	11	enzymatic study	Kuo LH (2008)	1
MAPK9	3	NCSTN	1	enzymatic study	Kuo LH (2008)	1
TRAF6	0	PSEN1	11	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Powell JC (2009), Elzinga BM (2009), Elzinga BM (2009), Yan R (2013), Yan R (2013), Gudey SK (2014), Gudey SK (2014)	7
UNK	3	PSMB1	1	affinity chromatography technology	Murn J (2015)	1
PSEN1	11	YME1L1	2	two hybrid	Pellegrini L (2001)	1
UBC	7	UBQLN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, two hybrid, pull down, two hybrid, pull down, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Matsumoto M (2005), Ko HS (2004), Ko HS (2004), Sokratous K (2012), Raasi S (2005), Raasi S (2005), Massey LK (2004), Ko HS (2004), Ko HS (2004), Rolland T (2014), Castaneda CA (2013), Nakayasu ES (2013), Nakayasu ES (2013), Kristariyanto YA (2015), Kristariyanto YA (2015), Kurlawala Z (2017)	16
PSEN1	11	IRAK2	3	affinity chromatography technology, affinity chromatography technology	Elzinga BM (2009), Elzinga BM (2009)	2
CDC37	0	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
APOE	1	PDCD4	2	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
UNK	3	KRAS	1	affinity chromatography technology	Murn J (2015)	1
PSEN1	11	APOE	1	two hybrid	Soler-Lopez M (2011)	1
UBQLN1	1	PSEN1	11	two hybrid, pull down, fluorescent resonance energy transfe, pull down	Mah AL (2000), Mah AL (2000), Thomas AV (2006), Ford DL (2006)	4
ECSIT	3	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
UBC	7	PSMB1	1	affinity chromatography technology	Matsumoto M (2005)	1
PTGER4	1	PSEN1	11	affinity chromatography technology	Hoshino T (2009)	1
CDH1	4	UBC	7	bioid	Guo Z (2014)	1
UBQLN1	1	PSEN2	3	two hybrid, pull down, two hybrid, pull down, pull down	Mah AL (2000), Mah AL (2000), Ford DL (2007), Ford DL (2007), Ford DL (2006)	5
RAD23A	1	PSMB1	1	affinity chromatography technology	Scanlon TC (2009)	1
NOS3	7	UMPS	4	two hybrid	Soler-Lopez M (2011)	1
CDH2	4	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, biochemical	Straub BK (2003), Wahl JK (2003), Havugimana PC (2012)	3
APP	1	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
CTNNB1	30	APP	1	pull down	Olah J (2011)	1
PSEN1	11	UBC	7	imaging technique	Gudey SK (2014)	1
CDC37	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	STAMBPL1	2	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
RNF32	0	ECSIT	3	two hybrid	Soler-Lopez M (2011)	1
GSAP	3	PSENEN	3	affinity chromatography technology	He G (2010)	1
CDH1	4	ACTN1	5	affinity chromatography technology	Hazan RB (1998)	1
ERN1	1	PSEN1	11	affinity chromatography technology	Katayama T (1999)	1
PSEN1	11	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
BCL2	0	KRAS	1	affinity chromatography technology, affinity chromatography technology	Wang X (2009), Wang X (2009)	2
PSEN1	11	CFL1	0	two hybrid	Soler-Lopez M (2011)	1
ECSIT	3	NDUFS8	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GAPDH	0	PRDX2	1	biochemical	Wan C (2015)	1
RNF32	0	PRAM1	4	two hybrid, pull down	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN1	11	ST13	2	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSEN1	11	PSEN1	11	two hybrid, affinity chromatography technology	Hebert SS (2003), Hebert SS (2004)	2
PSEN2	3	RNF32	0	two hybrid	Soler-Lopez M (2011)	1
STAMBPL1	2	UBC	7	x-ray crystallography	Sato Y (2008)	1
PSENEN	3	ERLIN2	2	affinity chromatography technology, affinity chromatography technology	Teranishi Y (2012), Teranishi Y (2012)	2
PSEN1	11	GAPDH	0	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	PSMA5	0	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Van Gassen G (1999), Van Gassen G (1999), Van Gassen G (1999), Van Gassen G (1999)	4
APP	1	PSEN2	3	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
CLSTN1	0	PSEN1	11	affinity chromatography technology	Araki Y (2004)	1
CDC37	0	PRDX2	1	two hybrid	Soler-Lopez M (2011)	1
NOTCH1	25	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, pull down	Jin YH (2009), Jin YH (2009), Jin YH (2009)	3
CDC37	0	GFAP	0	affinity chromatography technology	Li J (2013)	1
PSEN1	11	PRAM1	4	two hybrid	Soler-Lopez M (2011)	1
CDH1	4	PSEN1	11	affinity chromatography technology, affinity chromatography technology	Georgakopoulos A (1999), Serban G (2005)	2
NOTCH1	25	APP	1	genetic interference, affinity chromatography technology	Kim SY (2007), Kim SY (2007)	2
CDH8	2	CTNNA1	7	affinity chromatography technology	Huttlin EL (2017)	1
PKP4	5	CDH1	4	two hybrid, bioid	Hatzfeld M (2003), Guo Z (2014)	2
KRAS	1	PSEN1	11	genetic interference	Luo J (2009)	1
PSMA5	0	PSMB1	1	biochemical, biochemical, biochemical, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017)	4
PSENEN	3	APH1A	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Baulac S (2003), Baulac S (2003), Kimberly WT (2003), Hebert SS (2004), Suzuki Y (2009), Sato T (2007), Yonemura Y (2011), Kuo LH (2008)	8
HERPUD1	2	UBC	7	affinity chromatography technology	Sai X (2003)	1
CFL1	0	GAPDH	0	biochemical	Wan C (2015)	1
PSEN1	11	KCNIP4	0	two hybrid	Morohashi Y (2002)	1
ECSIT	3	RAB3A	0	two hybrid	Soler-Lopez M (2011)	1
RNF32	0	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
CDC37	0	APOE	1	two hybrid, affinity chromatography technology	Soler-Lopez M (2011), Soler-Lopez M (2011)	2
PSENEN	3	PSEN2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Steiner H (2002), Hebert SS (2004), Yonemura Y (2011)	3
PSEN1	11	FLNB	11	two hybrid, pull down	Zhang W (1998), Zhang W (1998)	2
PSEN1	11	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
CDH8	2	CTNNB1	30	affinity chromatography technology, affinity chromatography technology	Kido M (1998), Huttlin EL (2017)	2
MAPT	1	UBC	7	affinity chromatography technology	Mesco ER (1991)	1
PSEN2	3	BCL2L1	0	two hybrid, affinity chromatography technology	Passer BJ (1999), Passer BJ (1999)	2
PSEN2	3	GFAP	0	two hybrid	Nielsen AL (2002)	1
DSP	8	PSEN1	11	biochemical, affinity chromatography technology, pull down	Havugimana PC (2012), Raurell I (2006), Raurell I (2006)	3
RYR2	26	PSEN1	11	pull down	Payne AJ (2013)	1
TCF4	26	EPB41L3	5	two hybrid	Rolland T (2014)	1
UNK	3	CTNNB1	30	affinity chromatography technology	Murn J (2015)	1
CTNND1	4	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
ECSIT	3	STAMBPL1	2	two hybrid	Soler-Lopez M (2011)	1
APP	1	AP1M2	2	two hybrid	Soler-Lopez M (2011)	1
UBQLN1	1	GAPDH	0	biochemical	Kristensen AR (2012)	1
CDC37	0	TUBA1B	0	affinity chromatography technology	Li J (2013)	1
CDC37	0	STAMBPL1	2	two hybrid	Soler-Lopez M (2011)	1
CTNNA1	7	CTNND1	4	affinity chromatography technology	Daniel JM (1995)	1
PSEN2	3	KCNIP3	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Buxbaum JD (1998), Choi EK (2001), Buxbaum JD (1998), Buxbaum JD (1998)	4
APH1B	0	PSEN1	11	affinity chromatography technology	Hebert SS (2004)	1
CDC37	0	GCDH	2	two hybrid	Soler-Lopez M (2011)	1
PSEN1	11	CIB1	2	two hybrid	Stabler SM (1999)	1
PSEN1	11	FBXL12	1	two hybrid	Soler-Lopez M (2011)	1
CTNNB1	30	TCF4	26	pull down, affinity chromatography technology, x-ray crystallography, pull down, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fasolini M (2003), Li Q (2004), Poy F (2001), Iguchi H (2007), Notani D (2010), Tran H (2008), Sanchez-Tillo E (2011), Selbach M (2006), Hamada F (2004), Hamada F (2004), Ponce E (2014), Wu B (2013), Wu B (2013), Yamamoto H (2003), Xu X (2014), Levy L (2004), Levy L (2004), Levy L (2004), Wang H (2008), Jansson EA (2005), Kotlyar M (2015), Zhu Z (2014), Lu D (2012), Lu D (2012), Lee HK (2007)	25
APOE	1	CYP2C18	2	two hybrid	Soler-Lopez M (2011)	1