PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NTRK1	1	WRN	6	affinity chromatography technology	Emdal KB (2015)	1
CDC5L	2	NUP107	1	affinity chromatography technology	Lleres D (2010)	1
NTRK1	1	UBC	7	affinity chromatography technology	Emdal KB (2015)	1
USP11	3	UBC	7	enzymatic study, pull down, pull down	Faesen AC (2011), Zhang X (2017), Kwasna D (2018)	3
USP25	0	UBC	7	enzymatic study, pull down, enzymatic study, pull down, pull down, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, enzymatic study, pull down	Faesen AC (2011), Nathan JA (2013), Meulmeester E (2008), Meulmeester E (2008), Zhang X (2017), Yang Y (2017), Wrigley JD (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kawaguchi K (2017), Kwasna D (2018)	12
UBC	7	TOLLIP	3	pull down, pull down, pull down, biochemical, pull down, pull down, pull down, pull down	Fenner BJ (2009), Nathan JA (2013), Mitra S (2013), Mitra S (2013), Shih SC (2003), Lu K (2014), Lu K (2014), Zhang X (2017)	8
CDC5L	2	WRNIP1	3	affinity chromatography technology	Lleres D (2010)	1
WRNIP1	3	WRNIP1	3	affinity chromatography technology	Tsurimoto T (2005)	1
NUP107	1	WRNIP1	3	affinity chromatography technology, affinity chromatography technology	Kaur S (2010), Kaur S (2010)	2
EGLN3	0	POLD1	5	affinity chromatography technology	Rodriguez J (2016)	1
WRNIP1	3	USP11	3	affinity chromatography technology	Sowa ME (2009)	1
UBC	7	VCP	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Matsumoto M (2005), Zhong X (2006), Dai RM (2001), Bish RA (2007), Lim JJ (2016), Zhang X (2017)	6
PIN1	0	SMAD2	5	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nakano A (2009), Nakano A (2009), Matsuura I (2010), Matsuura I (2010)	4
CDC5L	2	SRSF4	2	affinity chromatography technology	Lleres D (2010)	1
ELP3	5	PCNA	0	affinity chromatography technology	Li Q (2009)	1
MAVS	1	RNF31	3	affinity chromatography technology	Khan M (2016)	1
NTRK1	1	USP11	3	affinity chromatography technology	Emdal KB (2015)	1
FGFR1OP	0	ABL1	9	affinity chromatography technology	Mano Y (2007)	1
ATMIN	0	WRNIP1	3	affinity chromatography technology, affinity chromatography technology	Kanu N (2016), Kanu N (2016)	2
PIK3R3	0	WRNIP1	3	two hybrid	Grossmann A (2015)	1
DDX58	3	IRF3	4	affinity chromatography technology, affinity chromatography technology	Friedman CS (2008), Xu LG (2005)	2
PPP6C	7	WRNIP1	3	affinity chromatography technology	Tan P (2017)	1
EGLN3	0	PPP6C	7	affinity chromatography technology	Rodriguez J (2016)	1
NTRK1	1	PPP6C	7	affinity chromatography technology	Emdal KB (2015)	1
RNF31	3	VCP	6	affinity chromatography technology, pull down, x-ray crystallography, unspecified method	Schaeffer V (2014), Schaeffer V (2014), Schaeffer V (2014), Elliott PR (2014)	4
UBC	7	WRNIP1	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down	Nathan JA (2013), Bish RA (2007), Bish RA (2007), Bish RA (2007), Bish RA (2007), Herhaus L (2015), Zhang X (2017)	7
TRIM14	1	PPP6C	7	two hybrid, affinity chromatography technology, bioid	Tan P (2017), Tan P (2017), Tan P (2017)	3
NTRK1	1	ELP3	5	affinity chromatography technology	Emdal KB (2015)	1
XPO1	8	ABL1	9	unspecified method, unspecified method	Xu D (2012), Hantschel O (2005)	2
EPAS1	6	UBC	7	affinity chromatography technology	Steunou AL (2012)	1
SRSF4	2	WRNIP1	3	biochemical	Havugimana PC (2012)	1
NTRK1	1	XPO1	8	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	CDC5L	2	affinity chromatography technology	Emdal KB (2015)	1
USP37	1	UBC	7	unspecified method, affinity chromatography technology, pull down, enzymatic study, pull down, pull down	Ernst A (2013), Tanno H (2014), Tanno H (2014), Tanno H (2014), Kawaguchi K (2017), Kwasna D (2018)	6
USP25	0	WRNIP1	3	affinity chromatography technology	Sowa ME (2009)	1
WRN	6	VCP	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Partridge JJ (2003), Partridge JJ (2003), Indig FE (2004)	3
DDX58	3	PPP6C	7	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2
MCM9	1	WRNIP1	3	affinity chromatography technology, affinity chromatography technology	Hutchins JR (2016), Traver S (2015)	2
PCNA	0	POLD1	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology	Ohta S (2002), Naryzhny SN (2005), Naryzhny SN (2004), Ogi T (2010), Shikata K (2001), Shikata K (2001), Xie B (2002), Li H (2006), Park JM (2014), Han J (2014), Hein MY (2015)	11
EGLN3	0	XPO1	8	affinity chromatography technology	Rodriguez J (2016)	1
USP11	3	OSBPL10	1	affinity chromatography technology	Sowa ME (2009)	1
UBC	7	ABL1	9	affinity chromatography technology, two hybrid	Chen R (2013), Chen R (2013)	2
RPS6KB2	3	WRNIP1	3	affinity chromatography technology	Roy R (2014)	1
PIN1	0	WRNIP1	3	pull down	Ingham RJ (2005)	1
UBC	7	TRIM28	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Doyle JM (2010)	2
NTRK1	1	NUP107	1	affinity chromatography technology	Emdal KB (2015)	1
FOXP3	1	ELP3	5	affinity chromatography technology	Li X (2015)	1
RNF31	3	DDX58	3	affinity chromatography technology, affinity chromatography technology	Inn KS (2011), Inn KS (2011)	2
DDX58	3	UBC	7	pull down, pull down	Feng M (2012), Zeng W (2010)	2
RPS6KB2	3	PCNA	0	affinity chromatography technology	Roy R (2014)	1
NTRK1	1	RNF31	3	affinity chromatography technology	Emdal KB (2015)	1
EPAS1	6	WRNIP1	3	affinity chromatography technology	Steunou AL (2012)	1
EGLN3	0	PCNA	0	affinity chromatography technology	Rodriguez J (2016)	1
RNF31	3	UBC	7	pull down, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, pull down, enzymatic study, enzymatic study	Wauer T (2013), Fujita H (2014), Schaeffer V (2014), Tokunaga F (2011), Kirisako T (2006), Haas TL (2009), Emmerich CH (2013), Sakamoto H (2015), Lechtenberg BC (2016), Lechtenberg BC (2016), Stieglitz B (2012), Zhang X (2017), Kliza K (2017), Liu J (2017)	14
FGFR1OP	0	ELP3	5	affinity chromatography technology	Hein MY (2015)	1
IRF3	4	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Li S (2011), Wang Y (2012), Xu LG (2005), Liu S (2015), Liu S (2015), Zhou Z (2014)	6
NTRK1	1	POLD1	5	affinity chromatography technology	Emdal KB (2015)	1
EGLN3	0	NUP107	1	affinity chromatography technology	Rodriguez J (2016)	1
VCP	6	PPP6C	7	affinity chromatography technology	Yu CC (2013)	1
FGFR1OP	0	WRNIP1	3	affinity chromatography technology	Mano Y (2007)	1
PCNA	0	WRN	6	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, fluorescent resonance energy transfe	Rodriguez-Lopez AM (2003), Rodriguez-Lopez AM (2003), Huang S (2000), Kobayashi J (2010), Baynton K (2003)	5
WRNIP1	3	TRIM28	1	biochemical	Kristensen AR (2012)	1
SMAD2	5	WRNIP1	3	affinity chromatography technology	Brown KA (2008)	1
VCP	6	NUP107	1	affinity chromatography technology	Yu CC (2013)	1
ELP2	1	WRNIP1	3	biochemical	Kristensen AR (2012)	1
XPO1	8	POLD1	5	affinity chromatography technology	Kirli K (2015)	1
FOXA3	0	NUP107	1	affinity chromatography technology	Li X (2015)	1
XPO1	8	TOLLIP	3	affinity chromatography technology	Kirli K (2015)	1
FOXP3	1	WRNIP1	3	affinity chromatography technology	Li X (2015)	1
CDC5L	2	POLD1	5	affinity chromatography technology	Lleres D (2010)	1
VCP	6	WRNIP1	3	affinity chromatography technology	Yu CC (2013)	1
EGLN3	0	ELP2	1	affinity chromatography technology	Rodriguez J (2016)	1
NTRK1	1	TRIM28	1	affinity chromatography technology	Emdal KB (2015)	1
USP37	1	WRNIP1	3	bioid	Yeh C (2015)	1
SMAD2	5	IRF3	4	affinity chromatography technology	Qing J (2004)	1
XPO1	8	IRF3	4	affinity chromatography technology	Kirli K (2015)	1
FOXP3	1	NUP107	1	affinity chromatography technology	Li X (2015)	1
TOLLIP	3	WRNIP1	3	affinity chromatography technology, pull down	Li S (2011), Li S (2011)	2
DDX58	3	MAVS	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gack MU (2010), Gack MU (2009), Nistal-Villan E (2010), Kawai T (2005), Li S (2011), Li S (2011), Inn KS (2011), Arnaud N (2011), Maharaj NP (2011), Meylan E (2005), Xu LG (2005), Cui J (2010), Wei C (2010), Zhang H (2015), Tan P (2017)	15
XPO1	8	RAD18	3	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	PPP6C	7	affinity chromatography technology	Kirli K (2015)	1
UBC	7	RAD18	3	affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down	Matsumoto M (2005), Fenner BJ (2009), Bish RA (2007), Rizzo AA (2014), Rizzo AA (2014), Shereda RD (2010), Shereda RD (2010), Panier S (2012), Ali AM (2012), Thach TT (2015)	10
CDC5L	2	RAD18	3	affinity chromatography technology	Lleres D (2010)	1
FOXP3	1	USP11	3	affinity chromatography technology	Li X (2015)	1
NTRK1	1	ABL1	9	two hybrid, affinity chromatography technology, pull down	Koch A (2000), Yano H (2000), Koch A (2000)	3
IRF3	4	WRNIP1	3	affinity chromatography technology	Li X (2015)	1
XPO1	8	WRNIP1	3	affinity chromatography technology	Kirli K (2015)	1
EGLN3	0	ELP3	5	affinity chromatography technology	Rodriguez J (2016)	1
WRNIP1	3	POLD1	5	affinity chromatography technology	Tsurimoto T (2005)	1
FOXA3	0	WRNIP1	3	affinity chromatography technology	Li X (2015)	1
ABL1	9	WRNIP1	3	enzymatic study	Mano Y (2007)	1
WRN	6	WRNIP1	3	two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Kawabe Yi (2001), Kawabe Yi (2001), Kawabe Yi (2001), Kawabe Yi (2001)	4
RAD18	3	PCNA	0	enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Song IY (2010), Inagaki A (2011), Kobayashi J (2010), Masuda Y (2010), Watanabe K (2004), Watanabe K (2004), Watanabe K (2004), Notenboom V (2007), Notenboom V (2007), Wong RP (2011), Masuda Y (2012), Unk I (2006), Tomida J (2008), Durando M (2013), Han J (2014), Han J (2014), Han J (2014), Masuda Y (2012), Masuda Y (2015), Guan J (2017)	20
NUP107	1	XPO1	8	bioid	Kim DI (2014)	1
PCNA	0	WRNIP1	3	pull down	Kanu N (2016)	1
NTRK1	1	ELP2	1	affinity chromatography technology	Emdal KB (2015)	1
OSBPL10	1	WRNIP1	3	affinity chromatography technology	Sowa ME (2009)	1
WRN	6	CDC5L	2	affinity chromatography technology, affinity chromatography technology	Zhang N (2005), Zhang N (2005)	2
MAVS	1	PPP6C	7	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2
NTRK1	1	VCP	6	affinity chromatography technology	Emdal KB (2015)	1
FOXA3	0	FOXP3	1	affinity chromatography technology	Li X (2015)	1
NTRK1	1	WRNIP1	3	affinity chromatography technology	Emdal KB (2015)	1
XPO1	8	FGFR1OP	0	affinity chromatography technology	Kirli K (2015)	1
DDX58	3	WRNIP1	3	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology	Li S (2011), Li S (2011), Tan P (2017), Tan P (2017), Tan P (2017)	5
MAVS	1	ABL1	9	affinity chromatography technology, affinity chromatography technology, far western blotting	Song T (2010), Song T (2010), Song T (2010)	3
EGLN3	0	VCP	6	affinity chromatography technology	Rodriguez J (2016)	1
IRF3	4	PIN1	0	affinity chromatography technology, affinity chromatography technology	Saitoh T (2006), Saitoh T (2006)	2
TRIM14	1	WRNIP1	3	two hybrid, affinity chromatography technology	Tan P (2017), Tan P (2017)	2
EGLN3	0	EPAS1	6	two hybrid, affinity chromatography technology, pull down	Koeditz J (2007), Steunou AL (2012), Barth S (2007)	3
TRIM14	1	MAVS	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, imaging technique	Zhou Z (2014), Zhou Z (2014), Zhou Z (2014), Tan P (2017), Tan P (2017)	5
HDAC11	0	WRNIP1	3	affinity chromatography technology	Joshi P (2013)	1
EGLN3	0	WRNIP1	3	affinity chromatography technology	Rodriguez J (2016)	1
RNF31	3	WRNIP1	3	affinity chromatography technology	Schaeffer V (2014)	1
ELP3	5	WRNIP1	3	biochemical	Kristensen AR (2012)	1
MAVS	1	WRNIP1	3	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2
NTRK1	1	PCNA	0	affinity chromatography technology	Emdal KB (2015)	1
EGLN3	0	PIK3R3	0	affinity chromatography technology	Rodriguez J (2016)	1
EPAS1	6	XPO1	8	affinity chromatography technology	Steunou AL (2012)	1
TRIM14	1	SRSF4	2	bioid	Tan P (2017)	1
RAD18	3	WRNIP1	3	affinity chromatography technology, affinity chromatography technology	Yoshimura A (2009), Yoshimura A (2009)	2
PIK3R3	0	VCP	6	two hybrid	Grossmann A (2015)	1
ELP2	1	ELP3	5	affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology	Li Q (2009), Li Q (2009), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Dong C (2015)	6
ABL1	9	PCNA	0	affinity chromatography technology	Zhao H (2012)	1
DDX58	3	TRIM14	1	affinity chromatography technology, imaging technique	Tan P (2017), Tan P (2017)	2