PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YWHAZ	1	APP	1	pull down	Olah J (2011)	1
PAK6	0	MDM2	2	affinity chromatography technology, affinity chromatography technology, enzymatic study	Liu T (2012), Liu T (2012), Liu T (2012)	3
YWHAQ	0	YWHAG	5	affinity chromatography technology, biochemical	Pozuelo-Rubio M (2010), Kristensen AR (2012)	2
PAK6	0	MAPK14	0	two hybrid	Vinayagam A (2011)	1
AR	3	PAK6	0	two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, enzymatic study	Yang F (2001), Lee SR (2002), Lee SR (2002), Yang F (2001), Yang F (2001), Liu T (2012)	6
PAK4	3	APP	1	pull down	Olah J (2011)	1
CDK1	0	HSP90AA1	7	affinity chromatography technology	Garcia-Morales P (2007)	1
PAK6	0	RAC1	7	affinity chromatography technology, pull down	Woolery AR (2014), Lee SR (2002)	2
CDC42	3	CDH1	4	pull down, affinity chromatography technology	Shen Y (2008), Shen Y (2008)	2
YWHAE	0	MAPK14	0	biochemical	Wan C (2015)	1
YWHAQ	0	AR	3	pull down	Zilliacus J (2001)	1
HSP90AA1	7	APP	1	affinity chromatography technology	Kumar P (2007)	1
HSP90AA1	7	MYC	2	affinity chromatography technology	Carystinos GD (2003)	1
NEK6	2	PAK6	0	two hybrid	Wang J (2011)	1
FBXO7	1	HSP90AA1	7	affinity chromatography technology	Teixeira FR (2016)	1
YWHAE	0	PAK4	3	affinity chromatography technology	Gloeckner CJ (2007)	1
CDH1	4	PAK6	0	bioid	Guo Z (2014)	1
ESR1	0	HSP90AA1	7	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nair SC (1996), Lee MO (2002), Fan M (2005), Tateishi Y (2004), Fiskus W (2007), Powell E (2010), Suzuki T (2011), Berry NB (2008), Sumanasekera WK (2003), Taipale M (2012), Donley C (2013), Donley C (2013), Dhamad AE (2016)	13
CDK1	0	PAK6	0	two hybrid	Wang J (2011)	1
PAK4	3	RAC1	7	affinity chromatography technology	Dan C (2002)	1
ESR1	0	MYC	2	affinity chromatography technology	Cheng AS (2006)	1
PAK6	0	TPD52L1	1	two hybrid	Wang J (2011)	1
YWHAG	5	PAK4	3	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
HSP90AA1	7	PAK6	0	affinity chromatography technology	Taipale M (2012)	1
MDM2	2	YWHAQ	0	affinity chromatography technology, pull down, affinity chromatography technology	Pereg Y (2006), Wang B (2010), Wang B (2010)	3
YWHAZ	1	YWHAG	5	biochemical, biochemical, affinity chromatography technology, fluorescent resonance energy transfe	Kristensen AR (2012), Wan C (2015), Hein MY (2015), Ivanov AA (2017)	4
APP	1	MYC	2	pull down	Virok DP (2011)	1
PAK4	3	PAK6	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MYC	2	PAK6	0	genetic interference	Toyoshima M (2012)	1
CDH1	4	SNX2	4	bioid	Guo Z (2014)	1
YWHAQ	0	TPD52L1	1	affinity chromatography technology	Ichimura T (2013)	1
YWHAE	0	YWHAQ	0	two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Bandyopadhyay S (2010), Pozuelo-Rubio M (2010), Gloeckner CJ (2007), Wang J (2011)	4
PAK6	0	YWHAE	0	affinity chromatography technology	Huttlin EL (2017)	1
YWHAQ	0	ESR1	0	pull down	Zilliacus J (2001)	1
MDM2	2	CDH1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yang JY (2006), Yang JY (2006), Yang JY (2006), Adhikary A (2014)	4
PAK6	0	SEMA3B	0	two hybrid	Wang J (2011)	1
LNX1	7	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
LNX1	7	PAK6	0	affinity chromatography technology	Wolting CD (2011)	1
PAK4	3	CDC42	3	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, biochemical, affinity chromatography technology	Ewing RM (2007), Dan C (2002), Abo A (1998), Bandyopadhyay S (2010), Wan C (2015), Dart AE (2015)	6
YWHAQ	0	PAK4	3	affinity chromatography technology, pull down	Ewing RM (2007), Meek SE (2004)	2
MYC	2	YWHAQ	0	affinity chromatography technology	Koch HB (2007)	1
PAK6	0	SNX2	4	two hybrid	Wang J (2011)	1
MAPK14	0	MYC	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HSP90AA1	7	LNX1	7	affinity chromatography technology	Taipale M (2012)	1
PAK6	0	YWHAZ	1	affinity chromatography technology	Huttlin EL (2017)	1
NEK6	2	CDC42	3	two hybrid, pull down	Vaz Meirelles G (2010), Vaz Meirelles G (2010)	2
PAK6	0	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
PAK6	0	YWHAG	5	affinity chromatography technology	Huttlin EL (2017)	1
CDH1	4	YWHAE	0	bioid	Guo Z (2014)	1
YWHAQ	0	YWHAZ	1	affinity chromatography technology, biochemical, affinity chromatography technology	Pozuelo-Rubio M (2010), Kristensen AR (2012), Hein MY (2015)	3
APP	1	YWHAG	5	two hybrid, affinity chromatography technology, unspecified method	Sumioka A (2005), Sumioka A (2005), Sumioka A (2005)	3
MYC	2	MDM2	2	fluorescent resonance energy transfe	Ivanov AA (2017)	1
MDM2	2	HSP90AA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, biochemical, unspecified method, affinity chromatography technology	Lu TL (2010), Burch L (2004), Burch L (2004), Burch L (2004), Burch L (2004), Burch LR (2004), Okoro DR (2013)	7
PAK6	0	RHOJ	0	two hybrid	Rolland T (2014)	1
YWHAZ	1	YWHAE	0	two hybrid, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, two hybrid, biochemical, biochemical, affinity chromatography technology, pull down	Bandyopadhyay S (2010), Zippo A (2009), Zippo A (2009), Havugimana PC (2012), Gloeckner CJ (2007), Wang J (2011), Kristensen AR (2012), Wan C (2015), Hein MY (2015), Gu YM (2006)	10
HSP90AA1	7	AR	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Veldscholte J (1992), Nemoto T (1992), Zoubeidi A (2007), DaSilva J (2009), Chymkowitch P (2011), Gibbs A (2009), Wolf SS (2007), Luo J (2015), Kwegyir-Afful AK (2015), Ni L (2010), McClurg UL (2016)	11
CDH1	4	YWHAZ	1	bioid	Guo Z (2014)	1
MYC	2	YWHAE	0	affinity chromatography technology	Koch HB (2007)	1
NEK6	2	LNX1	7	two hybrid	Rolland T (2014)	1
CDH1	4	HSP90AA1	7	affinity chromatography technology	Catimel B (2005)	1
ESR1	0	MDM2	2	pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down	Liu G (2000), Kinyamu HK (2003), Duong V (2007), Duong V (2007), Duong V (2007), Duong V (2007), Saji S (2001), Saji S (2001)	8
CDC42	3	PAK6	0	pull down, two hybrid	Lee SR (2002), Bandyopadhyay S (2010)	2
AR	3	MDM2	2	affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zoubeidi A (2007), Gaughan L (2005), Gaughan L (2005), Chymkowitch P (2011), Chymkowitch P (2011), Liu T (2012), Liu T (2012), Deep G (2008), Deep G (2008), Lin HK (2002), Lin HK (2002), Zhang A (2015), Kwegyir-Afful AK (2015), McClurg UL (2016), McClurg UL (2016), Liao Y (2017), Steely AM (2017), Zhai W (2016)	18
FBXO7	1	PAK6	0	enzymatic study	Teixeira FR (2016)	1
MDM2	2	APP	1	pull down	Miyamoto-Sato E (2010)	1
PAK6	0	ESR1	0	pull down	Lee SR (2002)	1
YWHAG	5	YWHAE	0	two hybrid, affinity chromatography technology, two hybrid, biochemical	Bandyopadhyay S (2010), Gloeckner CJ (2007), Wang J (2011), Wan C (2015)	4
YWHAQ	0	PAK6	0	affinity chromatography technology	Ewing RM (2007)	1
CDH1	4	PAK4	3	bioid	Guo Z (2014)	1
YWHAZ	1	PAK4	3	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004)	2
YWHAZ	1	MDM2	2	affinity chromatography technology	Zhang B (2017)	1