PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SHD	3	BECN1	2	two hybrid	Grossmann A (2015)	1
SHD	3	KRTCAP2	0	two hybrid	Grossmann A (2015)	1
SHD	3	OLIG1	0	two hybrid	Grossmann A (2015)	1
SHD	3	CAPN10	1	two hybrid	Grossmann A (2015)	1
SHD	3	MRPS22	0	two hybrid	Grossmann A (2015)	1
SHD	3	OSBPL6	5	two hybrid	Grossmann A (2015)	1
ABL1	9	SHD	3	two hybrid, enzymatic study	Oda T (1997), Oda T (1997)	2
SHD	3	PSG11	1	two hybrid	Grossmann A (2015)	1