PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CTNNBIP1	1	GLB1	3	affinity chromatography technology	Ewing RM (2007)	1
CTNNBIP1	1	KRTAP10-7	0	two hybrid	Rolland T (2014)	1
APC	5	CTNNB1	30	affinity chromatography technology, far western blotting, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Su LK (1993), Su LK (1993), Kucerova D (2001), Tickenbrock L (2003), Davies G (2001), Ryo A (2001), Homma MK (2002), Tickenbrock L (2003), Davies G (2001), Satoh K (1997), Eklof Spink K (2001), Eklof Spink K (2001), Sierra J (2006), Choi J (2004), Huang X (2009), Brocardo MG (2011), Xing Y (2004), Xing Y (2004), Xing Y (2004), Hamada F (2004), Hamada F (2004), Schneikert J (2013), Hsi LC (1999), Hein MY (2015), Hein MY (2015), Chen TC (2014), Kuslansky Y (2016), Novellasdemunt L (2017), Novellasdemunt L (2017)	29
RUVBL2	4	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down	Kim JH (2006), Lee JS (2010), Kim JH (2005), Kim JH (2005), Bauer A (2000)	5
CTNNBIP1	1	BPGM	1	affinity chromatography technology	Huttlin EL (2017)	1
CTNNBIP1	1	PNMA2	0	affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Huttlin EL (2017)	2
CTNNA2	6	JUP	7	biochemical	Wan C (2015)	1
CTNNBIP1	1	CTNNA1	7	affinity chromatography technology	Huttlin EL (2017)	1
JUP	7	CTNNBIP1	1	two hybrid, affinity chromatography technology	Rual JF (2005), Ewing RM (2007)	2
CTNNB1	30	JUP	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique	Hazan RB (1998), Kucerova D (2001), Hein MY (2015), Chen TC (2014)	4
CTNNBIP1	1	BEND5	0	two hybrid	Rual JF (2005)	1
CTNNBIP1	1	PPP2R1A	8	affinity chromatography technology	Ewing RM (2007)	1
CTNNBIP1	1	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
JUP	7	APC	5	pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique	Shibata T (1994), Daniel JM (1995), Bandyopadhyay S (2010), Hein MY (2015), Chen TC (2014)	5
CTNNA3	3	CTNNBIP1	1	affinity chromatography technology	Huttlin EL (2017)	1
CTNNBIP1	1	83955	0	affinity chromatography technology	Ewing RM (2007)	1
RPA3	2	RUVBL2	4	affinity chromatography technology	Marechal A (2014)	1
RUVBL2	4	CTNNBIP1	1	affinity chromatography technology	Rashid S (2009)	1
CTNNA2	6	CTNNB1	30	biochemical	Wan C (2015)	1
CTNNBIP1	1	INCA1	1	two hybrid	Rolland T (2014)	1
CTNNBIP1	1	CTNNA2	6	affinity chromatography technology	Huttlin EL (2017)	1
CTNNBIP1	1	APC	5	affinity chromatography technology	Huttlin EL (2017)	1
CTNNA3	3	APC	5	affinity chromatography technology	Huttlin EL (2017)	1
CTNNBIP1	1	RPA3	2	affinity chromatography technology	Ewing RM (2007)	1
CTNNBIP1	1	USHBP1	1	two hybrid	Rolland T (2014)	1
RPA3	2	ELAVL1	0	affinity chromatography technology	Marechal A (2014)	1
CASP4	1	CTNNBIP1	1	affinity chromatography technology	Ewing RM (2007)	1
CTSA	2	GLB1	3	affinity chromatography technology	Boldt K (2016)	1
CTNNB1	30	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, pull down	Oyama T (1994), Roe S (1998), Piedra J (2003), Aberle H (1994), Reuver SM (1998), Selbach M (2006), Tian Q (2004), Wan C (2015), Hein MY (2015), Ji H (2009), Ji H (2009)	11
CTNNBIP1	1	CTSA	2	affinity chromatography technology	Ewing RM (2007)	1
KRTAP10-7	0	KRTAP10-3	1	two hybrid	Rolland T (2014)	1
CTNNBIP1	1	CTNNB1	30	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Tago K (2000), Selbach M (2006), Daniels DL (2002), Chen Y (2016), Huttlin EL (2017)	6
CTNNB1	30	ELAVL1	0	pull down	Kim I (2012)	1
CTNNBIP1	1	TK2	1	affinity chromatography technology	Huttlin EL (2017)	1
CTNNA3	3	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Janssens B (2001), Waaijers S (2013), Chen TC (2014), Huttlin EL (2017)	4
JUP	7	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, biochemical, biochemical, imaging technique	Roe S (1998), Roe S (1998), Sacco PA (1995), Obama H (1997), Bandyopadhyay S (2010), Havugimana PC (2012), Wan C (2015), Chen TC (2014)	8
CTNNBIP1	1	GOT2	0	affinity chromatography technology	Ewing RM (2007)	1
CTNNA3	3	CTNNA1	7	affinity chromatography technology	Waaijers S (2013)	1
PPP2R1A	8	CTNNA2	6	affinity chromatography technology	Fogeron ML (2013)	1
CTNNA3	3	JUP	7	affinity chromatography technology, affinity chromatography technology	Waaijers S (2013), Waaijers S (2013)	2
ELAVL1	0	PPP2R1A	8	affinity chromatography technology	Abdelmohsen K (2009)	1
ELAVL1	0	CTNNBIP1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
APC	5	CTNNA1	7	affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, imaging technique, affinity chromatography technology	Su LK (1993), Daniel JM (1995), Bandyopadhyay S (2010), Hein MY (2015), Chen TC (2014), Novellasdemunt L (2017)	6
CTNNBIP1	1	CPVL	0	affinity chromatography technology	Ewing RM (2007)	1
REL	5	CTNNBIP1	1	two hybrid	Rolland T (2014)	1