PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
YAE1D1	1	CHD3	19	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
ABCE1	2	ORAOV1	0	affinity chromatography technology	Kaerblane K (2015)	1
YAE1D1	1	NACAD	4	two hybrid	Vinayagam A (2011)	1
YAE1D1	1	VIM	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
XPO1	8	HAUS5	0	affinity chromatography technology	Kirli K (2015)	1
YAE1D1	1	SERPINA4	0	two hybrid	Vinayagam A (2011)	1
YAE1D1	1	BBS10	2	two hybrid	Vinayagam A (2011)	1
COPS5	0	YAE1D1	1	affinity chromatography technology	Bennett EJ (2010)	1
TPD52L1	1	YAE1D1	1	two hybrid	Stelzl U (2005)	1
CUL2	3	HNRNPA2B1	2	affinity chromatography technology	Bennett EJ (2010)	1
XPO1	8	ABCE1	2	affinity chromatography technology	Kirli K (2015)	1
CHD3	19	VIM	0	two hybrid	Goehler H (2004)	1
CUL3	17	VIM	0	affinity chromatography technology	Bennett EJ (2010)	1
YAE1D1	1	HAUS5	0	two hybrid	Vinayagam A (2011)	1
XPO1	8	VIM	0	affinity chromatography technology	Kirli K (2015)	1
FAM96B	0	YAE1D1	1	affinity chromatography technology	Stehling O (2013)	1
YAE1D1	1	METTL18	4	two hybrid	Vinayagam A (2011)	1
COPS5	0	CUL3	17	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Olma MH (2009), Huttlin EL (2017)	8
CUL3	17	CUL2	3	biochemical	Wan C (2015)	1
YAE1D1	1	APP	1	pull down	Olah J (2011)	1
USP53	1	YAE1D1	1	affinity chromatography technology	Sowa ME (2009)	1
YAE1D1	1	ZNF579	2	two hybrid	Vinayagam A (2011)	1
YAE1D1	1	ORAOV1	0	two hybrid	Zhai C (2013)	1
YAE1D1	1	CEP126	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
CUL2	3	YAE1D1	1	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
YAE1D1	1	HNRNPA2B1	2	two hybrid	Vinayagam A (2011)	1
CUL3	17	HNRNPA2B1	2	affinity chromatography technology	Bennett EJ (2010)	1
XPO1	8	BBS10	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	YAE1D1	1	affinity chromatography technology	Kirli K (2015)	1
CUL3	17	ABCE1	2	affinity chromatography technology	Bennett EJ (2010)	1
VIM	0	CRMP1	0	two hybrid, pull down, two hybrid	Vinayagam A (2011), Goehler H (2004), Goehler H (2004)	3
FAM96B	0	ABCE1	2	affinity chromatography technology	Stehling O (2013)	1
CIAO1	3	APP	1	pull down	Olah J (2011)	1
YAE1D1	1	MCF2L	4	two hybrid	Vinayagam A (2011)	1
COPS5	0	HNRNPA2B1	2	affinity chromatography technology	Bennett EJ (2010)	1
CUL3	17	YAE1D1	1	affinity chromatography technology	Bennett EJ (2010)	1
COPS5	0	VIM	0	affinity chromatography technology	Bennett EJ (2010)	1
ABCE1	2	VIM	0	affinity chromatography technology	Kaerblane K (2015)	1
CIAO1	3	YAE1D1	1	affinity chromatography technology	Stehling O (2013)	1
ABCE1	2	YAE1D1	1	affinity chromatography technology	Kaerblane K (2015)	1
CIAO1	3	ABCE1	2	affinity chromatography technology, affinity chromatography technology	Stehling O (2013), Kaerblane K (2015)	2
COPS5	0	CUL2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Sowa ME (2009), Choo YY (2011), Bennett EJ (2010), Bennett EJ (2010), Bennett EJ (2010), Olma MH (2009), Pick E (2012)	7
COPS5	0	APP	1	pull down, affinity chromatography technology	Olah J (2011), Wang H (2013)	2
YAE1D1	1	NAT14	0	two hybrid	Vinayagam A (2011)	1
YAE1D1	1	SLC25A33	0	two hybrid	Vinayagam A (2011)	1
VIM	0	APP	1	pull down	Olah J (2011)	1
CIAO1	3	FAM96B	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, biochemical, two hybrid	Rual JF (2005), Havugimana PC (2012), Stehling O (2013), Stehling O (2013), Stehling O (2013), Stehling O (2013), Rolland T (2014), Gari K (2012), Wan C (2015), Yu H (2011)	10
YAE1D1	1	CRMP1	0	two hybrid	Vinayagam A (2011)	1