PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CHMP4B	2	SPAST	8	affinity chromatography technology	Hein MY (2015)	1
CHMP5	0	CHMP1B	0	two hybrid	Tsang HT (2006)	1
CHMP1B	0	CHMP1B	0	two hybrid	Tsang HT (2006)	1
CLTC	12	CHMP1B	0	affinity chromatography technology	Hein MY (2015)	1
ORC1	3	CHMP1B	0	affinity chromatography technology	Hein MY (2015)	1
USP54	5	CHMP1B	0	pull down	Rigden DJ (2009)	1
TFG	3	IST1	0	affinity chromatography technology	Hein MY (2015)	1
IST1	0	VPS4A	4	biochemical	Wan C (2015)	1
CHMP1B	0	RAB11A	4	two hybrid	Tsang HT (2006)	1
CHMP3	0	RAB11A	4	two hybrid	Tsang HT (2006)	1
ELAVL1	0	CHMP1B	0	affinity chromatography technology	Abdelmohsen K (2009)	1
CLTC	12	IST1	0	affinity chromatography technology	Hein MY (2015)	1
USP54	5	CHMP4C	1	pull down	Rigden DJ (2009)	1
TRIM25	5	ELAVL1	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
STAMBP	2	CHMP1A	3	affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Agromayor M (2006), Agromayor M (2006), Row PE (2007), Row PE (2007), Tsang HT (2006), Tsang HT (2006), Wang J (2011), Huttlin EL (2015), Huttlin EL (2017)	9
TFG	3	CHMP1B	0	affinity chromatography technology	Hein MY (2015)	1
CHMP1B	0	CNOT10	0	two hybrid	Tsang HT (2006)	1
STAMBP	2	CHMP1B	0	affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, two hybrid, imaging technique, affinity chromatography technology, two hybrid, two hybrid	Agromayor M (2006), Agromayor M (2006), Row PE (2007), Row PE (2007), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Wang J (2011), Rolland T (2014)	10
CHMP1B	0	SSRP1	1	two hybrid	Tsang HT (2006)	1
CHMP1B	0	SUCLG1	0	two hybrid	Tsang HT (2006)	1
TFG	3	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1
TFG	3	TRIM25	5	affinity chromatography technology	Lee NR (2013)	1
VPS4A	4	CHMP3	0	affinity chromatography technology	Kuang Z (2011)	1
CHMP1B	0	KNSTRN	0	two hybrid	Tsang HT (2006)	1
CHMP3	0	CHMP1B	0	biochemical	Wan C (2015)	1
TFG	3	CHMP5	0	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	SPAST	8	affinity chromatography technology	Abdelmohsen K (2009)	1
VPS4A	4	CHMP1B	0	two hybrid, two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006), Tsang HT (2006)	3
TFG	3	CHMP3	0	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	RAB11A	4	affinity chromatography technology	Abdelmohsen K (2009)	1
ATP6V1B1	4	CHMP1A	3	affinity chromatography technology	Nylandsted J (2011)	1
TFG	3	CHMP1A	3	affinity chromatography technology	Hein MY (2015)	1
CHMP3	0	CHMP4B	2	two hybrid, two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Tsang HT (2006), Wan C (2015), Hein MY (2015)	4
RNF103-CHMP3	0	CHMP1B	0	biochemical	Wan C (2015)	1
CHMP5	0	STAMBP	2	two hybrid	Wang J (2011)	1
CHMP4C	1	CHMP1B	0	biochemical	Wan C (2015)	1
CHMP1A	3	CHMP1B	0	two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006)	2
RNF103-CHMP3	0	CHMP4B	2	biochemical	Wan C (2015)	1
CLTC	12	CHMP1A	3	affinity chromatography technology	Hein MY (2015)	1
STAMBP	2	CLTC	12	affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Nakamura M (2006), Nakamura M (2006), McCullough J (2006), McCullough J (2006), McCullough J (2006), Hein MY (2015)	6
USP8	7	CHMP1B	0	two hybrid, pull down, affinity chromatography technology, pull down	Row PE (2007), Row PE (2007), Row PE (2007), Rigden DJ (2009)	4
TRIM25	5	VPS4A	4	affinity chromatography technology	Choudhury NR (2017)	1
ATP6V1B1	4	CHMP4B	2	affinity chromatography technology	Nylandsted J (2011)	1
CHMP1A	3	VPS4A	4	affinity chromatography technology, pull down, two hybrid, two hybrid, two hybrid, two hybrid	Howard TL (2001), Howard TL (2001), Howard TL (2001), von Schwedler UK (2003), Tsang HT (2006), Tsang HT (2006)	6
ATP6V1B1	4	CHMP1B	0	affinity chromatography technology	Nylandsted J (2011)	1
TRIM25	5	CHMP1B	0	affinity chromatography technology	Choudhury NR (2017)	1
CHMP4B	2	CHMP1A	3	affinity chromatography technology	Hein MY (2015)	1
SPAST	8	IST1	0	two hybrid, pull down, affinity chromatography technology	Renvoise B (2010), Renvoise B (2010), Huttlin EL (2017)	3
USP8	7	CHMP1A	3	pull down, pull down	Row PE (2007), Rigden DJ (2009)	2
ATP6V1B1	4	CHMP5	0	affinity chromatography technology	Nylandsted J (2011)	1
IST1	0	CHMP1A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
IST1	0	CHMP1B	0	affinity chromatography technology, biochemical	Xiao J (2009), Wan C (2015)	2
STAMBP	2	CHMP4B	2	two hybrid, two hybrid, two hybrid	Row PE (2007), Tsang HT (2006), Tsang HT (2006)	3
USP8	7	CHMP4C	1	pull down, pull down	Row PE (2007), Rigden DJ (2009)	2
CHMP1B	0	SNRNP200	15	two hybrid	Tsang HT (2006)	1
CHMP5	0	CHMP4B	2	two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Wan C (2015), Hein MY (2015)	3
CHMP4C	1	CHMP4B	2	two hybrid, two hybrid	von Schwedler UK (2003), Tsang HT (2006)	2
CHMP5	0	CHMP3	0	affinity chromatography technology	Huttlin EL (2017)	1
CHMP4B	2	IST1	0	affinity chromatography technology	Hein MY (2015)	1
ATP6V1B1	4	IST1	0	affinity chromatography technology	Nylandsted J (2011)	1
VPS4A	4	CHMP5	0	affinity chromatography technology	Kuang Z (2011)	1
VPS4A	4	CHMP4B	2	two hybrid, two hybrid	Tsang HT (2006), Tsang HT (2006)	2
STAMBP	2	CHMP4C	1	pull down	Row PE (2007)	1
STAMBP	2	CHMP3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, imaging technique, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology	Sowa ME (2009), Kyuuma M (2006), Kyuuma M (2006), Kyuuma M (2006), Agromayor M (2006), Agromayor M (2006), Row PE (2007), Row PE (2007), Ma YM (2007), Ma YM (2007), McCullough J (2006), Zamborlini A (2006), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Tsang HT (2006), Rolland T (2014), Huttlin EL (2015), Lata S (2008), Huttlin EL (2017)	20
SPAST	8	CHMP1B	0	two hybrid, pull down	Renvoise B (2010), Renvoise B (2010)	2
WDR5	2	CHMP1B	0	affinity chromatography technology	Bailey JK (2015)	1
CHMP4B	2	CHMP1B	0	two hybrid, biochemical, affinity chromatography technology	Tsang HT (2006), Wan C (2015), Hein MY (2015)	3
CLTC	12	RAB11A	4	affinity chromatography technology	Hein MY (2015)	1
CHMP4C	1	VPS4A	4	two hybrid	von Schwedler UK (2003)	1
ATP6V1B1	4	CHMP3	0	affinity chromatography technology	Nylandsted J (2011)	1
CHMP1B	0	RASSF7	0	two hybrid	Tsang HT (2006)	1
CHMP5	0	CHMP1A	3	affinity chromatography technology	Huttlin EL (2017)	1
TRIM25	5	USP54	5	affinity chromatography technology	Choudhury NR (2017)	1
CLTC	12	CHMP4B	2	affinity chromatography technology	Hein MY (2015)	1