PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SMURF2	3	TRAF4	1	two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study	Colland F (2004), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013), Zhang L (2013)	8
SMAD6	9	SMAD7	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Topper JN (1997), Topper JN (1997), Topper JN (1997), Yan X (2016)	4
FZR1	1	UBE2D3	1	pull down	Jin L (2008)	1
SMURF2	3	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fukunaga E (2008), Fukunaga E (2008), Lee YS (2011), Huttlin EL (2017)	4
BTRC	1	UBE2D3	1	pull down	Chong RA (2014)	1
SMAD5	2	SMAD6	9	affinity chromatography technology	Murakami G (2003)	1
SMAD7	1	SMURF2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Asano Y (2004), Kavsak P (2000), Lee YS (2008), Komuro A (2004), Chong PA (2010), Chong PA (2010), Chong PA (2010), Cai Y (2012), Cai Y (2012), Chong PA (2006), Al-Salihi MA (2012), Ogunjimi AA (2005), Aragon E (2012), Aragon E (2012), Colland F (2004), Zhang L (2013), Chandhoke AS (2015), Iyengar PV (2015), Elkouris M (2016)	19
SMAD3	1	BTRC	1	affinity chromatography technology	Wan M (2004)	1
SMURF2	3	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down	Kim S (2010), Nie J (2010), Lu K (2011), Maspero E (2013), Kristariyanto YA (2015), Mari S (2014), Emanuelli A (2017)	7
SMURF2	3	UBE2L3	1	pull down, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down	Wiesner S (2007), Ogunjimi AA (2005), Kim S (2010), Ogunjimi AA (2005), Anindya R (2007), Kristariyanto YA (2015), Zhang W (2016)	7
SMAD3	1	USP9X	15	affinity chromatography technology	Dupont S (2009)	1
SMAD7	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Asano Y (2004), Yamaguchi T (2006), Komuro A (2004), Ebisawa T (2001), Ebisawa T (2001), Al-Salihi MA (2012), Suzuki C (2002), Aragon E (2012), Aragon E (2012), Tajima Y (2003), Fei C (2013), Fei C (2014), Wan L (2011), Elkouris M (2016)	14
SMAD1	0	SMAD7	1	affinity chromatography technology	Yan X (2016)	1
SMAD7	1	SMAD3	1	genetic interference, genetic interference, affinity chromatography technology, protein complementation assay	Datta PK (2000), Lebrun JJ (1999), Yan X (2016), Yan X (2016)	4
SMURF1	4	TRIB2	2	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Wang J (2013), Wang J (2013), Wang J (2013), Xu S (2014)	4
RHOA	0	SMURF1	4	pull down, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Asanuma K (2006), Tian M (2011), Tian M (2011), Tian M (2011), Lee MG (2016), He S (2017)	6
SMAD3	1	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Bonni S (2001), Nakano A (2009), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Tang LY (2011), Brown KA (2008), Zhang L (2013), Li Y (2017), Zhang Y (2017)	12
SMAD3	1	SMAD1	0	affinity chromatography technology, two hybrid, two hybrid	Brown KA (2008), Wu RY (1997), Wu RY (1997)	3
SMURF2	3	FBXL15	0	affinity chromatography technology	Cui Y (2011)	1
UBE2L3	1	SMAD7	1	unspecified method	Ogunjimi AA (2005)	1
SMAD5	2	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, two hybrid, two hybrid, enzymatic study	Lu K (2008), Komuro A (2004), Ebisawa T (2001), Nie J (2010), Alarcon C (2009), Murakami G (2003), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Haag J (2006), Colland F (2004), Lu K (2008)	12
SMAD3	1	SMURF1	4	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Colland F (2004), Li Y (2017), Li Y (2017)	4
SMURF1	4	FBXL15	0	affinity chromatography technology, affinity chromatography technology, two hybrid, enzymatic study	Cui Y (2011), Cui Y (2011), Cui Y (2011), Cui Y (2011)	4
SMURF2	3	RHOA	0	pull down, enzymatic study, enzymatic study	Ogunjimi AA (2010), Lu K (2011), Wiesner S (2007)	3
SMURF1	4	AXIN1	1	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down	Fei C (2013), Fei C (2013), Fei C (2014), Fei C (2014), Fei C (2014)	5
SMURF1	4	SMURF1	4	enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Crose LE (2009), Aragon E (2012), Sheng Y (2012), Xie P (2014), Xie P (2014), Anindya R (2007), Lu K (2008), Wan L (2011), Wan L (2011), Wan L (2011), Zhang W (2016), He S (2017), He S (2017), Zhang Y (2017)	14
SMAD6	9	SMURF1	4	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology	Komuro A (2004), Ebisawa T (2001), Sangadala S (2007), Lee YS (2011), Lee YS (2011)	5
UBE2L3	1	USP9X	15	biochemical	Havugimana PC (2012)	1
TRIB2	2	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Wang J (2013), Wang J (2013), Xu S (2014), Qiao Y (2013), Qiao Y (2013)	5
BTRC	1	AXIN1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology	Kitagawa M (1999), Kitagawa M (1999), Li VS (2012), Coyaud E (2015), Coyaud E (2015), Novellasdemunt L (2017)	6
SMURF1	4	PLEKHO1	1	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lu K (2008), Lu K (2008), Nie J (2010), Nie J (2010), Wang Y (2012), Wang Y (2012), Wang Y (2012), Wan L (2011)	8
SMAD5	2	PLEKHO1	1	affinity chromatography technology, pull down	Lu K (2008), Lu K (2008)	2
SMURF1	4	USP9X	15	affinity chromatography technology, affinity chromatography technology, pull down, pull down	Xie Y (2013), Xie Y (2013), Xie Y (2013), Xie Y (2013)	4
PDLIM7	0	SMURF1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, pull down	Sangadala S (2006), Sangadala S (2006), Sangadala S (2006), Sangadala S (2006), Sangadala S (2007), Sangadala S (2007)	6
SMURF1	4	BTRC	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Cui Y (2011), Zhang Y (2017), Zhang Y (2017), Zhang Y (2017), Zhang Y (2017)	5
SMURF2	3	BTRC	1	enzymatic study, affinity chromatography technology	Shukla S (2014), Shukla S (2014)	2
SMURF1	4	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Nie J (2010), Nie J (2010), Fei C (2013), Wang J (2013), Cao Y (2014), Xie P (2014), Xie P (2014), Lu K (2008), Kristariyanto YA (2015), Andrews PS (2010), He S (2017), Zhang Y (2017)	12
SMURF1	4	UBE2L3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Cao Y (2014), Xie P (2014), Anindya R (2007), Kristariyanto YA (2015), Zhang W (2016), Andrews PS (2010), He S (2017), Zhang Y (2017)	8
FZR1	1	SMURF1	4	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Kannan M (2012), Kannan M (2012), Wan L (2011), Wan L (2011), Wan L (2011), Wan L (2011)	6
SMAD1	0	SMAD6	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid	Topper JN (1997), Murakami G (2003), Itoh F (2001), Hata A (1998), Hata A (1998)	5
BTRC	1	FZR1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study	Fukushima H (2013), Fukushima H (2013), Fukushima H (2013)	3
SMAD3	1	SMAD5	2	affinity chromatography technology	Brown KA (2008)	1
SMURF1	4	SMAD1	0	enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, pull down, unspecified method, two hybrid, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down	Sangadala S (2006), Komuro A (2004), Tian M (2011), Tian M (2011), Tian M (2011), Sapkota G (2007), Sapkota G (2007), Li L (2004), Alarcon C (2009), Aragon E (2011), Aragon E (2011), Aragon E (2011), Aragon E (2011), Gao S (2009), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Sangadala S (2007), Colland F (2004), Cao Y (2014), Cao Y (2014), Sangadala S (2007), Gao S (2009), Wan L (2011), Wan L (2011), Zhang Y (2017), Zhang Y (2017)	28
SMAD1	0	SMURF2	3	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Lin X (2000), Lin X (2000), Komuro A (2004), Zhang Y (2001), Zhang Y (2001), Li L (2004), Chong PA (2010), Colland F (2004), Huttlin EL (2017), Zhou F (2017)	10
FBXO3	0	SMURF1	4	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Li D (2015), Li D (2015), Li D (2015), Li D (2015)	4
SMAD6	9	SMURF2	3	affinity chromatography technology, two hybrid, affinity chromatography technology	Komuro A (2004), Colland F (2004), Herhaus L (2014)	3
SMURF1	4	ING2	0	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology	Nie J (2010), Nie J (2010), Nie J (2010), Nie J (2010)	4
SMURF1	4	TRAF4	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, genetic interference, enzymatic study	Li S (2010), Li S (2010), Li S (2010), Li S (2010), Li S (2010), Zhang L (2013)	6
SMAD5	2	SMURF2	3	affinity chromatography technology, enzymatic study, two hybrid, affinity chromatography technology	Komuro A (2004), Nie J (2010), Colland F (2004), Huttlin EL (2017)	4
SMAD1	0	USP9X	15	affinity chromatography technology	Dupont S (2009)	1
SMURF2	3	AXIN1	1	enzymatic study, affinity chromatography technology	Kim S (2010), Kim S (2010)	2
SMAD7	1	AXIN1	1	affinity chromatography technology	Tang Y (2008)	1
SMAD1	0	SMAD5	2	two hybrid	Colland F (2004)	1