PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PELI2	5	IRAK1	1	affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Butler MP (2007), Strelow A (2003), Strelow A (2003), Butler MP (2005), Schauvliege R (2006), Huoh YS (2014)	6
FRYL	12	PELI2	5	two hybrid	Wang J (2011)	1
TRAF6	0	IRAK2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Muzio M (1997), Keating SE (2007), Li S (2011), Li S (2011), Wang J (2011), Wang H (2015), Huttlin EL (2017)	8
PELI2	5	PICALM	0	two hybrid	Wang J (2011)	1
NR2C2	0	TRAF6	0	affinity chromatography technology	Rafferty BJ (2010)	1
LTBP3	6	PELI2	5	two hybrid	Wang J (2011)	1
IRAK4	0	PELI2	5	affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study	Butler MP (2007), Strelow A (2003), Strelow A (2003), Strelow A (2003)	4
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
IRAK1	1	IRAK2	3	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Li S (2011), Li S (2011), Ross K (2002), Ross K (2002)	4
HNRNPK	4	HNRNPL	3	two hybrid, two hybrid, pull down, pull down, biochemical, biochemical	Kim JH (2000), Kim JH (2000), Kim JH (2000), Kim JH (2000), Havugimana PC (2012), Wan C (2015)	6
FN1	17	HNRNPL	3	affinity chromatography technology	Humphries JD (2009)	1
HNRNPL	3	FRYL	12	affinity chromatography technology	Fei T (2017)	1
PELI2	5	NR2C2	0	affinity chromatography technology	Jensen LE (2003)	1
FN1	17	HNRNPK	4	affinity chromatography technology	Humphries JD (2009)	1
HNRNPL	3	PELI2	5	affinity chromatography technology	Fei T (2017)	1
HNRNPK	4	PELI2	5	two hybrid	Wang J (2011)	1
TRAF6	0	IRAK4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2002), Li S (2002), Zhang X (2013)	3
IRAK4	0	IRAK2	3	affinity chromatography technology	Li S (2011)	1
DEAF1	12	PELI2	5	two hybrid	Wang J (2011)	1
PELI2	5	THAP7	0	two hybrid	Wang J (2011)	1
LAMC3	9	PELI2	5	two hybrid	Wang J (2011)	1
IRAK4	0	IRAK1	1	affinity chromatography technology, enzymatic study, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2002), Li S (2002), Ulrichts P (2008), Li S (2011), Neumann D (2007), Burns K (2003), Liu G (2007), Strelow A (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Jeon J (2014)	13
PELI2	5	TRAF6	0	affinity chromatography technology, affinity chromatography technology	Jensen LE (2003), Huoh YS (2014)	2
UBQLN4	2	PELI2	5	two hybrid	Lim J (2006)	1
CREB3L3	1	PELI2	5	two hybrid	Wang J (2011)	1
ERO1A	0	PELI2	5	two hybrid	Wang J (2011)	1
PELI2	5	UQCRFS1	0	affinity chromatography technology	Huoh YS (2014)	1
IRAK2	3	PELI2	5	affinity chromatography technology	Butler MP (2007)	1
FN1	17	PICALM	0	affinity chromatography technology	Humphries JD (2009)	1
FN1	17	PELI2	5	two hybrid	Wang J (2011)	1
SRPK1	2	PELI2	5	enzymatic study	Varjosalo M (2013)	1