PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BIRC3	1	IKBKB	1	imaging technique	Chen TC (2014)	1
TRAF6	0	UBC	7	affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study	Muroi M (2011), Park S (2013), Sun L (2004), Kanayama A (2004), Sakamoto H (2015), Yu J (2016), Middleton AJ (2017)	7
PELI1	1	UBC	7	enzymatic study, enzymatic study	Smith H (2009), Smith H (2011)	2
TRAF6	0	IRAK2	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Muzio M (1997), Keating SE (2007), Li S (2011), Li S (2011), Wang J (2011), Wang H (2015), Huttlin EL (2017)	8
PELI1	1	BIRC3	1	affinity chromatography technology, pull down, pull down	Jeon YK (2016), Jeon YK (2016), Jeon YK (2016)	3
UBE2I	0	TRAF6	0	enzymatic study, enzymatic study	Li Y (2013), Pham LV (2008)	2
MYD88	1	IRAK4	0	affinity chromatography technology, protein complementation assay, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid	Li S (2002), Ulrichts P (2008), Ulrichts P (2008), Zhou J (2011), Zhou J (2011), Burns K (2003), Burns K (2003), Strelow A (2003), Loiarro M (2007), Jeon J (2014), Rolland T (2014)	11
SRPK2	1	VAC14	5	enzymatic study	Lipp JJ (2015)	1
UBE2N	1	BIRC3	1	two hybrid, pull down, two hybrid	van Wijk SJ (2009), Wu CJ (2006), Schimmack G (2017)	3
MYD88	1	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen BC (2002), Wesche H (1999), Li S (2002), Fitzgerald KA (2001), Fitzgerald KA (2001), Li S (2011), Neumann D (2007), Zhou J (2011), Burns K (2003), Mizobe T (2007), Loiarro M (2007), Choi KC (2006), Rao N (2005), Rao N (2005), Li CH (2006)	15
UBE2D2	0	UBE2V1	0	biochemical	Havugimana PC (2012)	1
PELI1	1	UBE2D2	0	pull down	Smith H (2009)	1
TRAF6	0	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down	Cai B (2017), Fang R (2017), Fang R (2017)	3
UBC	7	IKBKB	1	pull down	Zhang X (2017)	1
IKBKB	1	PELI1	1	enzymatic study	Smith H (2011)	1
MDM4	0	UBC	7	enzymatic study	Egorova O (2014)	1
PELI1	1	MYD88	1	affinity chromatography technology	Choi KC (2006)	1
RIPK1	2	IKBKB	1	biochemical, pull down	Yang Y (2011), Poyet JL (2000)	2
NR2C2	0	TRAF6	0	affinity chromatography technology	Rafferty BJ (2010)	1
IRAK1	1	IKBKB	1	affinity chromatography technology, affinity chromatography technology	Vig E (2001), Windheim M (2008)	2
BIRC3	1	UBE2I	0	two hybrid, two hybrid	Dynek JN (2010), Dynek JN (2010)	2
IRAK2	3	PELI1	1	affinity chromatography technology	Butler MP (2007)	1
MYD88	1	IRAK2	3	affinity chromatography technology, genetic interference, affinity chromatography technology, affinity chromatography technology	Wesche H (1999), Fitzgerald KA (2001), Muzio M (1997), Zhou J (2011)	4
SRPK1	2	PELI1	1	enzymatic study	Varjosalo M (2013)	1
TBK1	1	PELI1	1	enzymatic study, affinity chromatography technology	Smith H (2011), Murphy M (2015)	2
IKBKB	1	IRS1	7	affinity chromatography technology	Gao Z (2002)	1
TRAF6	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology	Wesche H (1999), Qian Y (2001), Cao Z (1996), Takatsuna H (2003), Li S (2002), Ling L (2000), Ling L (2000), Takaesu G (2001), Muzio M (1997), Chen F (2008), Li X (2001), Li X (2001), Xiong Y (2011), Xiong Y (2011), Tang H (2010), Muroi M (2011), Liu A (2012), Lee JY (2009), Lee JY (2009), Kollewe C (2004), Jiang Z (2002), Jensen LE (2001), Liu G (2007), Liu G (2007), Jiang Z (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Lakshmanan U (2007), Lee HJ (2012), Lee HJ (2012), Zhang X (2013), Yao J (2007), Hu MM (2014), Jeon J (2014), Conze DB (2008), Tanishima M (2017)	38
IRAK4	0	PELI1	1	affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology	Butler MP (2007), Ordureau A (2008), Smith H (2009), Smith H (2011), Jiang Z (2003), Choi KC (2006)	6
MYD88	1	TRAF6	0	genetic interference, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fitzgerald KA (2001), Zhou J (2011), Zhou J (2011), Zhang X (2013), Zhang X (2013), Hirata Y (2006)	6
IL1R1	0	MYD88	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Burns K (2000), Muzio M (1997), Jiang Z (2003), Chen R (2012), Burns K (1998), Jeon J (2014)	6
UBE2D1	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
RIPK1	2	BIRC3	1	affinity chromatography technology, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Bertrand MJ (2008), Bertrand MJ (2008), Dynek JN (2010), Bertrand MJ (2011), Bertrand MJ (2011), Bertrand MJ (2011), Puliyappadamba VT (2013), Wu CJ (2006)	8
IRS1	7	PELI1	1	two hybrid	Grossmann A (2015)	1
TRAF6	0	BIRC3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Mao AP (2010), Goncharov T (2013), Harikumar KB (2014), Harikumar KB (2014)	4
BIRC3	1	UBE2V1	0	pull down, pull down	Bertrand MJ (2008), Wu CJ (2006)	2
BIRC3	1	UBE2D2	0	x-ray crystallography, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down	Mace PD (2008), Mace PD (2008), Dynek JN (2010), Feltham R (2011), Dou H (2012), Li X (2002), Schumacher FR (2013), Choi JS (2014), Wu CJ (2006), Fang S (2001), Hu S (2003), Suzuki S (2017)	12
MDM4	0	UBE2D1	0	pull down, pull down	Badciong JC (2002), Singh RK (2007)	2
IRAK1	1	IRAK2	3	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, fluorescent resonance energy transfe	Li S (2011), Li S (2011), Ross K (2002), Ross K (2002)	4
UBE2N	1	RIPK1	2	enzymatic study	Bohgaki M (2008)	1
VAC14	5	PELI1	1	two hybrid	Rolland T (2014)	1
IL1R1	0	IRAK1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2002), Jiang Z (2002), Chen R (2012), Cao Z (1996), Cao Z (1996), Rao N (2005), Jeon J (2014)	8
IL1R1	0	IRAK4	0	affinity chromatography technology	Jiang Z (2003)	1
UBE2V1	0	UBC	7	pull down	McKenna S (2003)	1
PELI1	1	UBE2N	1	pull down	Smith H (2011)	1
SMAD6	9	MYD88	1	affinity chromatography technology, affinity chromatography technology	Lee YS (2011), Lee YS (2011)	2
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
TRIP13	0	PELI1	1	two hybrid	Rolland T (2014)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
IRAK2	3	IL1R1	0	affinity chromatography technology	Muzio M (1997)	1
PELI1	1	NR2C2	0	affinity chromatography technology	Jensen LE (2003)	1
PELI1	1	UBE2D1	0	pull down	Smith H (2009)	1
PELI1	1	UBE2V1	0	pull down, pull down	Smith H (2011), Chang M (2009)	2
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
TRAF6	0	IRAK4	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li S (2002), Li S (2002), Zhang X (2013)	3
IRAK4	0	IRAK2	3	affinity chromatography technology	Li S (2011)	1
TRAF6	0	UBE2V1	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Deng L (2000), Lamothe B (2007), Kanayama A (2004), Shi CS (2010), Xia ZP (2009), Yang WL (2009), Murata H (2013), Ning S (2008), Sun L (2004), Lin Y (2014)	10
IRAK4	0	IRAK1	1	affinity chromatography technology, enzymatic study, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology	Li S (2002), Li S (2002), Ulrichts P (2008), Li S (2011), Neumann D (2007), Burns K (2003), Liu G (2007), Strelow A (2003), Nguyen T (2009), Choi KC (2006), Rao N (2005), Rao N (2005), Jeon J (2014)	13
TRAF6	0	UBE2N	1	genetic interference, pull down, two hybrid, biochemical, two hybrid, x-ray crystallography, two hybrid, enzymatic study, x-ray crystallography, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid, two hybrid	Deng L (2000), Deng L (2000), Markson G (2009), Yin Q (2009), Dynek JN (2010), Yin Q (2009), Yin Q (2009), Petroski MD (2007), Mercier P (2007), Lamothe B (2008), Kanayama A (2004), Murata H (2013), Ning S (2008), Markson G (2009), Lin Y (2014), Chen J (2015), Zhang J (2016), Boldt K (2016), Rezaeian AH (2017), Xing J (2016), Schimmack G (2017), Schimmack G (2017)	22
PELI1	1	IL1R1	0	affinity chromatography technology	Jiang Z (2003)	1
RIPK1	2	PELI1	1	affinity chromatography technology, enzymatic study	Chang M (2009), Chang M (2009)	2
UBE2N	1	UBE2V1	0	biochemical, pull down, pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Deng L (2000), Deng L (2000), Zhang M (2005), Andersen PL (2005), Andersen PL (2005), Scheper J (2010), Scheper J (2010), Scheper J (2010), Wooff J (2004), Plans V (2006), Huen MS (2008), Huen MS (2008), Havugimana PC (2012), Bohgaki M (2008), Petroski MD (2007), Sawasaki T (2008), Wan C (2015), Chen J (2015), Boldt K (2016), Zhang Y (2018)	20
IL1R1	0	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2002), Jiang Z (2003), Rafferty BJ (2010)	4
PELI1	1	SMAD6	9	affinity chromatography technology, affinity chromatography technology	Choi KC (2006), Choi KC (2006)	2
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
SRPK2	1	PELI1	1	enzymatic study	Varjosalo M (2013)	1
SRPK1	2	SRPK2	1	biochemical	Edmond V (2011)	1
MDM4	0	UBE2D2	0	pull down, enzymatic study	Iyappan S (2010), Bista M (2013)	2
BIRC3	1	UBE2D1	0	affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Hu S (2003), Dynek JN (2010), Dynek JN (2010), Bertrand MJ (2011), Hu S (2006), Guicciardi ME (2014)	6
PELI1	1	BCL6	6	pull down, affinity chromatography technology, enzymatic study	Park HY (2014), Park HY (2014), Park HY (2014)	3
PELI1	1	UBE2I	0	two hybrid, pull down	Kim JH (2011), Kim JH (2011)	2
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
IRS1	7	UBC	7	pull down	Xu X (2012)	1
BIRC3	1	UBC	7	pull down, pull down, enzymatic study	Gyrd-Hansen M (2008), Nakatani Y (2012), Sakamoto H (2015)	3
UBE2I	0	TRIP13	0	two hybrid	Yu H (2011)	1
PELI1	1	TRAF6	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jiang Z (2003), Jiang Z (2003), Choi KC (2006), Jensen LE (2003)	4
MDM4	0	PELI1	1	affinity chromatography technology	Huttlin EL (2017)	1
TRAF6	0	IKBKB	1	affinity chromatography technology	Bidere N (2006)	1
UBE2D2	0	TRAF6	0	two hybrid, pull down	Markson G (2009), Markson G (2009)	2
RIPK1	2	UBC	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gao L (2015), Ding Z (2015), Varfolomeev E (2015)	3
PELI1	1	IRAK1	1	affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Butler MP (2007), Ordureau A (2008), Lin CC (2008), Smith H (2009), Smith H (2011), Jiang Z (2003), Choi KC (2006), Choi KC (2006), Butler MP (2005), Schauvliege R (2006), Murphy M (2015)	11
PELI1	1	DEAF1	12	affinity chromatography technology	Ordureau A (2013)	1