PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CBX3	1	SENP7	5	affinity chromatography technology, affinity chromatography technology	Hauri S (2016), Hauri S (2016)	2
SENP7	5	CSTA	1	affinity chromatography technology	Hauri S (2016)	1
SENP7	5	TRIM28	1	affinity chromatography technology, enzymatic study, affinity chromatography technology	Garvin AJ (2013), Garvin AJ (2013), Hauri S (2016)	3
CBX3	1	MYL12B	0	affinity chromatography technology	Hauri S (2016)	1
CBX5	3	TRIM28	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2002), Cammas F (2002), Cammas F (2002), Nielsen AL (2001), Lechner MS (2000), Lechner MS (2005), Lechner MS (2005), Lechner MS (2005), Lechner MS (2005), Ryan RF (1999), Rosnoblet C (2011), Hu C (2012), Hu C (2012), White D (2012), Nozawa RS (2010), Kubota S (2013), Kubota S (2013), Kubota S (2013), Garvin AJ (2013), Huttlin EL (2017), Hauri S (2016)	21
CBX5	3	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lechner MS (2005), Lechner MS (2005), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Nozawa RS (2010), Hauri S (2016), Hauri S (2016)	8
CBX3	1	RBBP4	3	affinity chromatography technology	Hauri S (2016)	1
SUMO2	0	TRIM28	1	pull down	Ouyang J (2009)	1
CBX3	1	TRIM28	1	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Bandyopadhyay S (2010), Ryan RF (1999), Higo S (2010), Rosnoblet C (2011), Vermeulen M (2010), Hauri S (2016)	7
SENP7	5	RBBP4	3	affinity chromatography technology	Hauri S (2016)	1
SENP7	5	SUMO2	0	unspecified method	Garvin AJ (2013)	1
CBX3	1	AHDC1	28	affinity chromatography technology	Hauri S (2016)	1
FBXW7	2	SENP7	5	genetic interference	Bailey ML (2015)	1
SUMO2	0	CHAMP1	8	pull down	Ouyang J (2009)	1
CBX5	3	SENP7	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nozawa RS (2010), Garvin AJ (2013), Garvin AJ (2013), Hauri S (2016), Hauri S (2016)	5
CBX3	1	CBX5	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Nielsen AL (2001), Mateos-Langerak J (2007), Quivy JP (2004), Quivy JP (2004), Quivy JP (2004), Kiyomitsu T (2010), Rosnoblet C (2011), Nozawa RS (2010), Vermeulen M (2010), Vermeulen M (2010), Hauri S (2016), Hauri S (2016)	15
SETDB2	0	SENP7	5	affinity chromatography technology	Huttlin EL (2017)	1
SENP7	5	AHDC1	28	affinity chromatography technology	Hauri S (2016)	1
CBX5	3	CHAMP1	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nozawa RS (2010), Vermeulen M (2010), Hein MY (2015), Hauri S (2016)	4
CBX5	3	AHDC1	28	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Nozawa RS (2010), Vermeulen M (2010), Hauri S (2016)	3
SENP7	5	MYL12B	0	affinity chromatography technology	Hauri S (2016)	1
SENP7	5	CHAMP1	8	affinity chromatography technology	Hauri S (2016)	1
BCL6	6	SENP7	5	affinity chromatography technology	Miles RR (2005)	1
SUMO2	0	RBBP4	3	pull down	Ouyang J (2009)	1
CHAMP1	8	CBX3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Hauri S (2016)	3