PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ELAVL1	0	RAB31	1	affinity chromatography technology	Abdelmohsen K (2009)	1
GDI1	1	RAB31	1	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
RAB7A	0	RAB5A	0	two hybrid, biochemical, biochemical	Bucci C (1999), Havugimana PC (2012), Wan C (2015)	3
RAB5A	0	EEA1	3	fluorescent resonance energy transfe, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, x-ray crystallography, pull down	Galperin E (2003), Valsdottir R (2001), Raiborg C (2001), Miaczynska M (2004), Christoforidis S (2000), Schnatwinkel C (2004), Mishra A (2010), Mishra A (2010)	8
GDI1	1	RAB7A	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
RAB31	1	EEA1	3	pull down	Ng EL (2009)	1
ELAVL1	0	RAB22A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
RAB31	1	RAB22A	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
RABGEF1	1	RAB5A	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Zhu H (2009), Christoforidis S (2000), Aikawa Y (2012), Aikawa Y (2012)	4
ELAVL1	0	RAB5A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
APPL2	4	RAB22A	0	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
RBSN	2	RAB22A	0	pull down, x-ray crystallography	Eathiraj S (2005), Eathiraj S (2005)	2
RAB22A	0	RAB5A	0	affinity chromatography technology	Zhu H (2009)	1
RAB31	1	RAB5A	0	affinity chromatography technology	Huttlin EL (2015)	1
RAB3GAP1	5	RAB22A	0	two hybrid	Itoh T (2006)	1
RAB7A	0	RAB22A	0	two hybrid	Bucci C (1999)	1
RBSN	2	RAB5A	0	far western blotting, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Nielsen E (2000), Nielsen E (2000), Schnatwinkel C (2004), Eathiraj S (2005), Mishra A (2010)	5
ELAVL1	0	RAB7A	0	affinity chromatography technology	Abdelmohsen K (2009)	1
RABGEF1	1	RAB22A	0	affinity chromatography technology, affinity chromatography technology	Zhu H (2009), Zhu H (2009)	2
RAB5A	0	APPL2	4	pull down	Miaczynska M (2004)	1
EEA1	3	RAB22A	0	two hybrid, pull down	Kauppi M (2002), Kauppi M (2002)	2
ATP6V1B1	4	RAB22A	0	affinity chromatography technology	Nylandsted J (2011)	1
RAB5A	0	GDI1	1	affinity chromatography technology	Huttlin EL (2017)	1
GDI1	1	RAB22A	0	affinity chromatography technology	Huttlin EL (2017)	1
EEA1	3	RABGEF1	1	affinity chromatography technology	Christoforidis S (2000)	1