Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
PTGS2 5743 VALDECOXIB CHEMBL865 inhibitor PharmGKB, ChemblInteractions, DrugBank, TTD 12644588, 11752352, 10715145, 15494548, 12167567, 11060833, 12564662
PTGS2 5743 MESALAMINE CHEMBL704 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 12208114, 9256165, 12463455, 14742690, 16855178
PTGS2 5743 TENOXICAM CHEMBL302795 inhibitor TdgClinicalTrial, TEND, DrugBank, TTD 15756931, 15943176, 11563332, 11752352, 16245223, 9152412
PTGS2 5743 LENALIDOMIDE CHEMBL848 negative modulator DrugBank 15598423, 12720152
PTGS2 5743 ROFECOXIB CHEMBL122 inhibitor PharmGKB, TdgClinicalTrial, ChemblInteractions, DrugBank, TTD 10555907, 18922570, 10693877, 11398914, 11752352, 10643177, 20166930, 10566562, 10580458, 20724158
PTGS2 5743 MEFENAMIC ACID CHEMBL686 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 10393680, 7832763, 9626023, 11752352, 15792781, 17150210
PTGS2 5743 SUPROFEN CHEMBL956 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 11885959, 17139284, 17016423
PTGS2 5743 SALICYLIC ACID CHEMBL424 inhibitor TdgClinicalTrial, TEND, DrugBank 15348270, 5284360, 15035793, 15070163, 17259377, 15106733, 15199473
PTGS2 5743 GINSENG, ASIAN CHEMBL2108467 inhibitor DrugBank 15778128, 17436372, 15753395
PTGS2 5743 TIAPROFENIC ACID CHEMBL365795 inhibitor TdgClinicalTrial, TEND, DrugBank, TTD 2277128, 11752352, 17139284, 17016423
PTGS2 5743 RESVERATROL CHEMBL165 inhibitor DrugBank 11752352
PTGS2 5743 NIFLUMIC ACID CHEMBL63323 inhibitor TdgClinicalTrial, DrugBank, TTD 17098211, 17485303, 16301791
PTGS2 5743 NIMESULIDE CHEMBL56367 inhibitor PharmGKB, DrugBank, TTD 11752352, 16846549
PTGS2 5743 LORNOXICAM CHEMBL1569487 inhibitor DrugBank 17516707, 20399943, 10450786, 11846620
PTGS2 5743 FIROCOXIB CHEMBL69998 DrugBank 15077695
PTGS2 5743 DICLOFENAC CHEMBL139 inhibitor TdgClinicalTrial, ChemblInteractions, TEND
PTGS2 5743 APRICOXIB CHEMBL1835207 inhibitor TALC, TdgClinicalTrial, ChemblInteractions
PTGS2 5743 OLSALAZINE SODIUM CHEMBL1201013 inhibitor ChemblInteractions
PTGS2 5743 DERSALAZINE CHEMBL2106406 TdgClinicalTrial
PTGS2 5743 BALSALAZID CHEMBL1201346 TdgClinicalTrial
PTGS2 5743 CAPECITABINE CHEMBL1773 PharmGKB
PTGS2 5743 ARUNDIC ACID CHEMBL2107727 inhibitor TTD
PTGS2 5743 NAPROXEN SODIUM CHEMBL1200806 inhibitor ChemblInteractions
PTGS2 5743 DICLOFENAC POTASSIUM CHEMBL1200804 inhibitor ChemblInteractions
PTGS2 5743 OXAPROZIN POTASSIUM CHEMBL1200463 inhibitor ChemblInteractions
PTGS2 5743 NAPROXEN ETEMESIL CHEMBL2105683 inhibitor TdgClinicalTrial, ChemblInteractions
PTGS2 5743 ETODOLAC CHEMBL622 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 10594327, 12824918, 11752352, 11009046, 15198222, 11275997
PTGS2 5743 AMINOSALICYLIC ACID CHEMBL1169 inhibitor DrugBank 12208114, 9256165, 12463455, 14742690, 16855178
PTGS2 5743 NABUMETONE CHEMBL1070 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 15456329, 12047490, 11304699, 11752352, 7615202, 11153163
PTGS2 5743 SULINDAC CHEMBL15770 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 10485483, 11118042, 11078056, 10657949, 10372826
PTGS2 5743 NAPROXEN CHEMBL154 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 17532719, 11752352, 17612049, 17604186, 17521299, 17607546
PTGS2 5743 ASPIRIN CHEMBL25 inhibitor TdgClinicalTrial, ChemblInteractions, CIViC, TEND, DrugBank 11752352, 17181859, 17037745, 17033106, 17258197, 17301265, 17522398
PTGS2 5743 THALIDOMIDE CHEMBL468 antagonist TdgClinicalTrial, DrugBank 21507989, 12710892, 15982930, 15598423, 15446566, 15892618
PTGS2 5743 MAGNESIUM SALICYLATE CHEMBL2106755 inhibitor DrugBank 15348270, 15199473, 15106733, 15035793, 15070163
PTGS2 5743 SALSALATE CHEMBL154111 inhibitor TdgClinicalTrial, TEND, DrugBank 9711054, 10452868, 16808554, 12901032
PTGS2 5743 PHENTERMINE HYDROCHLORIDE CHEMBL1200912 DrugBank 10592235
PTGS2 5743 NAPROXCINOD CHEMBL2103831 inhibitor TdgClinicalTrial, ChemblInteractions
PTGS2 5743 ICOSAPENT ETHYL CHEMBL2095209 TdgClinicalTrial
PTGS2 5743 IBUPROFEN CHEMBL521 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, TTD
PTGS2 5743 KETOROLAC CHEMBL469 TdgClinicalTrial, TEND
PTGS2 5743 BISMUTH SUBSALICYLATE CHEMBL1120 inhibitor ChemblInteractions
PTGS2 5743 FLURBIPROFEN SODIUM CHEMBL1200990 inhibitor ChemblInteractions
PTGS2 5743 AMINOSALICYLATE SODIUM CHEMBL2096646 inhibitor ChemblInteractions
PTGS2 5743 MECLOFENAMATE SODIUM CHEMBL876 inhibitor ChemblInteractions
PTGS2 5743 CELECOXIB CHEMBL118 inhibitor TALC, ChemblInteractions, DrugBank, TTD, TdgClinicalTrial, MyCancerGenomeClinicalTrial 12093311, 12086402, 11752352, 12086292, 12055598, 12104042
PTGS2 5743 DIFLUNISAL CHEMBL898 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 11752352, 12852483, 11673972, 10825891, 8737748, 11315375
PTGS2 5743 BROMFENAC CHEMBL1077 inhibitor TdgClinicalTrial, TEND, DrugBank 16846546, 12016548, 16982289
PTGS2 5743 ETORICOXIB CHEMBL416146 inhibitor PharmGKB, TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 17139284, 17016423, 17164136, 17691997, 11752352, 17573128
PTGS2 5743 POMALIDOMIDE CHEMBL43452 inhibitor DrugBank 17308870
PTGS2 5743 AMINOSALICYLATE POTASSIUM CHEMBL1200584 inhibitor ChemblInteractions
PTGS2 5743 FLURBIPROFEN CHEMBL563 inhibitor TdgClinicalTrial, ChemblInteractions, TEND
PTGS2 5743 CHEMBL374385 CHEMBL374385 TdgClinicalTrial
PTGS2 5743 TOLMETIN CHEMBL1020 inhibitor TdgClinicalTrial, TEND, TTD
PTGS2 5743 CHEMBL364804 CHEMBL364804 inhibitor TTD
PTGS2 5743 ACETAMINOPHEN CHEMBL112 inhibitor TdgClinicalTrial, ChemblInteractions, TEND
PTGS2 5743 MECLOFENAMIC ACID CHEMBL509 TdgClinicalTrial, TEND
PTGS2 5743 IBUPROFEN SODIUM CHEMBL1241153 inhibitor ChemblInteractions
PTGS2 5743 DICLOFENAC SODIUM CHEMBL1034 inhibitor ChemblInteractions
PTGS2 5743 INDOMETHACIN SODIUM CHEMBL1200864 inhibitor ChemblInteractions
PTGS2 5743 OXAPROZIN CHEMBL1071 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 19338579, 9831331, 17024689, 9650852, 19952416, 12065695
PTGS2 5743 BROMFENAC SODIUM CHEMBL751 inhibitor ChemblInteractions
PTGS2 5743 MELOXICAM CHEMBL599 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 11752352, 10220944, 10381787, 10340919, 10381057, 10567199
PTGS2 5743 DIHOMO-GAMMA-LINOLENIC ACID CHEMBL465183 DrugBank 15990700, 11939906, 11121413, 16190133
PTGS2 5743 ICOSAPENT CHEMBL460026 inhibitor DrugBank 20463020, 17459764, 16141635, 12573452, 12562875, 16190133
PTGS2 5743 PIROXICAM CHEMBL527 inhibitor TdgClinicalTrial, ChemblInteractions, DrugBank, TTD 11752352, 11952155, 11785774, 15464832, 10381057, 11153163
PTGS2 5743 SULFASALAZINE CHEMBL421 inhibitor TdgClinicalTrial, ChemblInteractions, DrugBank 12208114, 9256165, 12463455, 14742690, 16855178
PTGS2 5743 PHENYLBUTAZONE CHEMBL101 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 15489888, 11752352, 15939622, 12213119
PTGS2 5743 CARPROFEN CHEMBL1316 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 15939622, 17181139, 11752352, 15198222, 10895904, 11703020
PTGS2 5743 KETOPROFEN CHEMBL571 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank, TTD 11814865, 11752352, 15198222, 14513718, 10895904, 11729362
PTGS2 5743 BALSALAZIDE DISODIUM CHEMBL1200760 inhibitor ChemblInteractions, DrugBank 12950415, 17139284, 17016423, 19743890, 17981262
PTGS2 5743 LUMIRACOXIB CHEMBL404108 inhibitor TdgClinicalTrial, TEND, DrugBank, TTD 14965322, 15177307, 11752352, 14552704, 15017615, 15655513
PTGS2 5743 ANTRAFENINE CHEMBL345524 inhibitor DrugBank 17532719, 11752352, 17612049, 17604186, 17521299, 17607546
PTGS2 5743 CYCLOSPORINE CHEMBL160 NCI 10999939
PTGS2 5743 HYDROXYCHLOROQUINE CHEMBL1535 NCI 14963695
PTGS2 5743 RESERPINE CHEMBL772 NCI 16081063
PTGS2 5743 POLMACOXIB CHEMBL166863 inhibitor TdgClinicalTrial, ChemblInteractions
PTGS2 5743 KETOROLAC TROMETHAMINE CHEMBL1201124 inhibitor ChemblInteractions
PTGS2 5743 CHEMBL68211 CHEMBL68211 inhibitor TTD
PTGS2 5743 FENOPROFEN CHEMBL1297 TdgClinicalTrial, TEND
PTGS2 5743 OXALIPLATIN CHEMBL414804 PharmGKB
PTGS2 5743 DICLOFENAC EPOLAMINE CHEMBL1201180 inhibitor ChemblInteractions
PTGS2 5743 OXYPHENBUTAZONE CHEMBL1228 inhibitor ChemblInteractions
PTGS2 5743 TOLMETIN SODIUM CHEMBL1200613 inhibitor ChemblInteractions
PTGS2 5743 IBUPROFEN LYSINE CHEMBL1201141 inhibitor ChemblInteractions
PTGS2 5743 FENOPROFEN CALCIUM CHEMBL2103736 inhibitor ChemblInteractions
PTGS2 5743 PARECOXIB SODIUM CHEMBL296913 inhibitor TTD
PTGS2 5743 FLUFENAMIC ACID CHEMBL23588 DrugBank 7864817
PTGS2 5743 LICOFELONE CHEMBL300982 TdgClinicalTrial, DrugBank 17015640
PTGS2 5743 RALOXIFENE CHEMBL81 NCI 15243281
PTGS2 5743 INDOMETHACIN CHEMBL6 inhibitor ChemblInteractions, TEND, DrugBank 15668944, 15831440, 15730717, 15667901, 15770365
PTGS2 5743 ANTIPYRINE CHEMBL277474 inhibitor DrugBank 11695253
PTGS2 5743 PARECOXIB CHEMBL1206690 inhibitor TdgClinicalTrial, DrugBank 10794682
PTGS2 5743 CIMICOXIB CHEMBL435381 TdgClinicalTrial, DrugBank 15481993
PTGS2 5743 NEPAFENAC CHEMBL1021 inhibitor TdgClinicalTrial, ChemblInteractions, TEND, DrugBank 10850857
PTGS2 5743 SULINDAC SULFIDE CHEMBL18797 NCI 15657353

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
PTGS2 rs5273 G celecoxib efficacy not stated Allele G is not associated with response to celecoxib in healthy individuals as compared to allele A. 16401468 827826504
PTGS2 rs20417 C cetuximab efficacy no Meta-analysis with 3 studies. The authors did not provide the exact number of patients but stated that "the median number of patients per analysis was 110 (range 50 - 740)". Most definitions of response were variations of the RECIST criteria. Allele C is not associated with response to cetuximab or panitumumab in people with Colorectal Neoplasms as compared to allele G. 27897268 1449165345
PTGS2 rs689466 CC celecoxib efficacy yes in terms of COX-2 inhibition. COX-2 activity was estimated by measuring the blood PGE2 level. The area under the effect curve (AUEC) of the rs689466 GG genotype was significantly lower than that for the AA or AG genotype. Genotype CC is associated with increased response to celecoxib in healthy individuals as compared to genotypes CT + TT. 29066864 1450373027