PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
HACE1	2	UBE2L3	1	pull down, pull down, pull down, pull down	Castillo-Lluva S (2012), Liu Z (2014), Zhang W (2016), Huang S (2016)	4
HACE1	2	RARB	2	affinity chromatography technology	Zhao J (2009)	1
HACE1	2	RARA	5	affinity chromatography technology	Zhao J (2009)	1
RAB4A	0	HACE1	2	pull down	Tang D (2011)	1
HACE1	2	NOXA1	0	affinity chromatography technology	Daugaard M (2013)	1
YBX1	1	HACE1	2	affinity chromatography technology, affinity chromatography technology	Palicharla VR (2015), Palicharla VR (2015)	2
HACE1	2	SNTG2	2	enzymatic study, pull down	Huang S (2016), Huang S (2016)	2
HACE1	2	RARG	2	affinity chromatography technology, affinity chromatography technology	Zhao J (2009), Zhao J (2009)	2
RARG	2	RARA	5	affinity chromatography technology	Huttlin EL (2017)	1
IRF7	2	HACE1	2	affinity chromatography technology	Li S (2011)	1
HACE1	2	HACE1	2	enzymatic study	Zhang W (2016)	1
NOXA1	0	RAC1	7	affinity chromatography technology	Kroviarski Y (2010)	1
HACE1	2	RAC1	7	enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Torrino S (2011), Torrino S (2011), Torrino S (2011), Castillo-Lluva S (2012), Castillo-Lluva S (2012), Castillo-Lluva S (2012), Daugaard M (2013), Palicharla VR (2015), Andrio E (2017)	9
RARA	5	RARB	2	affinity chromatography technology	Huttlin EL (2017)	1
OPTN	1	HACE1	2	two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology	Liu Z (2014), Liu Z (2014), Liu Z (2014), Liu Z (2014), Liu Z (2014), Liu Z (2014), Liu Z (2014)	7
HIF1AN	0	HACE1	2	affinity chromatography technology	Rodriguez J (2016)	1