PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
OFD1	3	CEP131	9	affinity chromatography technology, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
WDR83	1	GPATCH1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DVL3	7	WDR83	1	affinity chromatography technology	Huttlin EL (2017)	1
OFD1	3	HAUS8	2	bioid	Gupta GD (2015)	1
AHI1	4	CEP131	9	bioid	Gupta GD (2015)	1
CC2D2A	3	DVL3	7	bioid	Gupta GD (2015)	1
AHI1	4	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
STAU1	1	ZC3H15	2	affinity chromatography technology	Milev MP (2012)	1
B9D2	0	MKS1	3	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
CC2D2A	3	WDR55	1	bioid	Gupta GD (2015)	1
MKS1	3	HAUS8	2	bioid	Gupta GD (2015)	1
B9D2	0	TCTN3	2	bioid	Gupta GD (2015)	1
CC2D2A	3	ZC3H15	2	bioid	Gupta GD (2015)	1
OFD1	3	CCDC138	2	bioid, affinity chromatography technology	Gupta GD (2015), Hein MY (2015)	2
CC2D2A	3	MB21D2	2	bioid	Gupta GD (2015)	1
MKS1	3	MB21D2	2	bioid	Gupta GD (2015)	1
CC2D2A	3	GPATCH1	3	bioid	Gupta GD (2015)	1
CC2D2A	3	SRP9	0	bioid	Gupta GD (2015)	1
TCTN1	2	B9D2	0	affinity chromatography technology	Huttlin EL (2017)	1
SSX2IP	0	HAUS8	2	bioid	Gupta GD (2015)	1
CC2D2A	3	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
AHI1	4	MB21D2	2	bioid	Gupta GD (2015)	1
CC2D2A	3	UNC45A	1	bioid	Gupta GD (2015)	1
CC2D2A	3	AHI1	4	bioid	Gupta GD (2015)	1
CC2D2A	3	STAMBPL1	2	bioid	Gupta GD (2015)	1
CC2D2A	3	TDRD3	0	bioid	Gupta GD (2015)	1
PCM1	5	GPATCH1	3	bioid	Gupta GD (2015)	1
CC2D2A	3	ECH1	2	bioid	Gupta GD (2015)	1
CC2D2A	3	WDR83	1	bioid	Gupta GD (2015)	1
CC2D2A	3	NOP2	4	bioid	Gupta GD (2015)	1
TCTN3	2	TCTN1	2	affinity chromatography technology	Boldt K (2016)	1
SSX2IP	0	OFD1	3	bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	3
CC2D2A	3	B9D1	1	bioid	Gupta GD (2015)	1
LMNA	2	TRIM26	1	two hybrid	Dittmer TA (2014)	1
AHI1	4	CCDC138	2	bioid	Gupta GD (2015)	1
CC2D2A	3	NOLC1	2	bioid	Gupta GD (2015)	1
OFD1	3	UNC45A	1	bioid	Gupta GD (2015)	1
MKS1	3	ECH1	2	bioid	Gupta GD (2015)	1
SSX2IP	0	CEP131	9	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CC2D2A	3	CCDC138	2	bioid	Gupta GD (2015)	1
SSX2IP	0	ECH1	2	bioid	Gupta GD (2015)	1
CC2D2A	3	SNU13	0	bioid	Gupta GD (2015)	1
PCM1	5	HAUS8	2	bioid	Gupta GD (2015)	1
OFD1	3	WDR83	1	bioid	Gupta GD (2015)	1
AHI1	4	HAUS8	2	bioid	Gupta GD (2015)	1
B9D2	0	B9D1	1	bioid, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
AHI1	4	SSX2IP	0	bioid, bioid	Gupta GD (2015), Gupta GD (2015)	2
SSX2IP	0	GPATCH1	3	bioid	Gupta GD (2015)	1
CC2D2A	3	MKS1	3	bioid	Gupta GD (2015)	1
CC2D2A	3	XRN1	4	bioid	Gupta GD (2015)	1
TCTN1	2	MKS1	3	affinity chromatography technology	Huttlin EL (2017)	1
OFD1	3	PCM1	5	affinity chromatography technology, affinity chromatography technology, bioid, bioid, affinity chromatography technology	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Hein MY (2015)	5
NOP2	4	NOLC1	2	biochemical	Wan C (2015)	1
CC2D2A	3	SSX2IP	0	bioid	Gupta GD (2015)	1
CC2D2A	3	RPF2	1	bioid	Gupta GD (2015)	1
CC2D2A	3	HAUS8	2	bioid	Gupta GD (2015)	1
CC2D2A	3	OFD1	3	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
OFD1	3	GPATCH1	3	bioid	Gupta GD (2015)	1
CC2D2A	3	STAU1	1	bioid	Gupta GD (2015)	1
AHI1	4	PCM1	5	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CC2D2A	3	YTHDC2	11	bioid	Gupta GD (2015)	1
CC2D2A	3	LMNA	2	bioid	Gupta GD (2015)	1
STAU1	1	SRP72	5	affinity chromatography technology	Milev MP (2012)	1
SSX2IP	0	XRN1	4	bioid	Gupta GD (2015)	1
PCM1	5	CEP131	9	affinity chromatography technology, pull down, affinity chromatography technology, bioid	Akimov V (2011), Villumsen BH (2013), Gupta GD (2015), Gupta GD (2015)	4
NOP2	4	RPF2	1	biochemical	Wan C (2015)	1
SSX2IP	0	CCDC138	2	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
CC2D2A	3	TRIM26	1	bioid	Gupta GD (2015)	1
CC2D2A	3	TCTN3	2	bioid	Gupta GD (2015)	1
SSX2IP	0	DVL3	7	bioid	Gupta GD (2015)	1
SSX2IP	0	WDR83	1	bioid	Gupta GD (2015)	1
CC2D2A	3	CEP131	9	bioid	Gupta GD (2015)	1
AHI1	4	SRP72	5	bioid	Gupta GD (2015)	1
CC2D2A	3	ASCC2	3	bioid	Gupta GD (2015)	1
PCM1	5	XRN1	4	bioid	Gupta GD (2015)	1
PCM1	5	STAU1	1	bioid	Gupta GD (2015)	1
LMNA	2	GPATCH1	3	bioid	Roux KJ (2012)	1
TCTN1	2	CC2D2A	3	affinity chromatography technology	Huttlin EL (2017)	1
CC2D2A	3	SRP72	5	bioid	Gupta GD (2015)	1
MKS1	3	UNC45A	1	bioid	Gupta GD (2015)	1
CC2D2A	3	B9D2	0	bioid	Gupta GD (2015)	1
SNU13	0	NOLC1	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
PCM1	5	WDR83	1	bioid	Gupta GD (2015)	1
SSX2IP	0	TRIM26	1	bioid	Gupta GD (2015)	1
AHI1	4	UNC45A	1	bioid	Gupta GD (2015)	1
CC2D2A	3	YWHAH	0	bioid	Gupta GD (2015)	1
MKS1	3	B9D1	1	bioid, affinity chromatography technology	Gupta GD (2015), Boldt K (2016)	2
LMNA	2	NOP2	4	affinity chromatography technology	Depreux FF (2015)	1
LMNA	2	UNC45A	1	two hybrid	Dittmer TA (2014)	1
LMNA	2	RPF2	1	affinity chromatography technology	Depreux FF (2015)	1
CC2D2A	3	ASCC3	12	bioid	Gupta GD (2015)	1
ASCC2	3	ASCC3	12	biochemical, affinity chromatography technology	Wan C (2015), Huttlin EL (2017)	2
PCM1	5	CCDC138	2	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
SRP9	0	SRP72	5	affinity chromatography technology	Huttlin EL (2017)	1
PCM1	5	SSX2IP	0	affinity chromatography technology, affinity chromatography technology, bioid, bioid	Gupta GD (2015), Gupta GD (2015), Gupta GD (2015), Gupta GD (2015)	4