PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TOMM20	0	CEP126	0	two hybrid	Stelzl U (2005)	1
LPL	3	LUC7L2	0	two hybrid	Stelzl U (2005)	1
SNRPG	0	CEP126	0	two hybrid	Stelzl U (2005)	1
MLH1	6	CEP126	0	two hybrid	Daakour S (2016)	1
MAPK9	3	CEP126	0	two hybrid	Stelzl U (2005)	1
BMI1	0	STAU2	4	affinity chromatography technology	Cao Q (2014)	1
DGCR6	0	CEP126	0	two hybrid	Corominas R (2014)	1
MRPS6	0	CEP126	0	two hybrid	Stelzl U (2005)	1
BMI1	0	CEP126	0	two hybrid	Stelzl U (2005)	1
PTPRS	15	CEP126	0	two hybrid	Stelzl U (2005)	1
PBK	0	CEP126	0	two hybrid	Stelzl U (2005)	1
DUSP23	1	CEP126	0	two hybrid	Vinayagam A (2011)	1
BRD1	5	CEP126	0	two hybrid	Stelzl U (2005)	1
RUVBL1	2	CEP126	0	two hybrid	Stelzl U (2005)	1
DISC1	6	YWHAZ	1	two hybrid	Camargo LM (2007)	1
TNFRSF14	2	CEP126	0	two hybrid	Vinayagam A (2011)	1
TFG	3	CEP126	0	two hybrid	Stelzl U (2005)	1
LAMTOR5	1	CEP126	0	two hybrid	Stelzl U (2005)	1
RPA2	0	CEP126	0	two hybrid	Stelzl U (2005)	1
BMI1	0	ATRX	7	affinity chromatography technology, biochemical	Abdouh M (2016), Abdouh M (2016)	2
PIK3R3	0	CEP126	0	two hybrid	Vinayagam A (2011)	1
OFD1	3	CEP126	0	two hybrid	Stelzl U (2005)	1
ATP6V1F	1	CEP126	0	two hybrid	Stelzl U (2005)	1
ATRX	7	CEP126	0	two hybrid	Stelzl U (2005)	1
RAN	1	CEP126	0	two hybrid	Stelzl U (2005)	1
AIMP2	0	LUC7L2	0	two hybrid	Vinayagam A (2011)	1
PPP1CA	3	CEP126	0	two hybrid	Esteves SL (2012)	1
KLHL20	2	CEP126	0	two hybrid	Stelzl U (2005)	1
SAT1	0	CEP126	0	two hybrid	Stelzl U (2005)	1
KLHL20	2	LUC7L2	0	two hybrid	Stelzl U (2005)	1
DUSP12	1	CEP126	0	two hybrid	Stelzl U (2005)	1
BMI1	0	FXR1	0	affinity chromatography technology	Cao Q (2014)	1
GOLGB1	8	CEP126	0	two hybrid	Stelzl U (2005)	1
CSTF2	2	TFG	3	two hybrid	Rolland T (2014)	1
GSTO1	0	CEP126	0	two hybrid	Stelzl U (2005)	1
PMF1	0	CEP126	0	two hybrid	Stelzl U (2005)	1
GET4	3	TTR	0	two hybrid	Stelzl U (2005)	1
GET4	3	CEP126	0	two hybrid	Stelzl U (2005)	1
MLH1	6	RUVBL1	2	affinity chromatography technology	Cannavo E (2007)	1
RBM23	0	CEP126	0	two hybrid	Stelzl U (2005)	1
CRCT1	1	CEP126	0	two hybrid	Stelzl U (2005)	1
RPA2	0	NUDT21	0	affinity chromatography technology	Marechal A (2014)	1
RAN	1	EIF6	2	biochemical	Wan C (2015)	1
ROGDI	1	CEP126	0	two hybrid	Stelzl U (2005)	1
TXNDC9	0	NUDT21	0	biochemical	Wan C (2015)	1
ZNF24	1	CEP126	0	two hybrid	Stelzl U (2005)	1
SAT1	0	LUC7L2	0	two hybrid	Stelzl U (2005)	1
RBM23	0	LRRC1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NAP1L5	1	CEP126	0	two hybrid	Stelzl U (2005)	1
POLD1	5	RPA2	0	biochemical	Havugimana PC (2012)	1
PPP1CC	2	ZNF24	1	two hybrid	Fardilha M (2011)	1
EIF6	2	CEP126	0	two hybrid	Stelzl U (2005)	1
PPP1CC	2	CEP126	0	two hybrid	Esteves SL (2012)	1
PFDN1	0	CEP126	0	two hybrid	Stelzl U (2005)	1
DISC1	6	CEP126	0	two hybrid	Morris JA (2003)	1
PPP1CA	3	RUVBL1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Huttlin EL (2017), Yadav L (2017), Yadav L (2017)	4
PDCD5	0	CEP126	0	two hybrid	Stelzl U (2005)	1
YAE1D1	1	CEP126	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
KIF15	4	CEP126	0	two hybrid	Stelzl U (2005)	1
TNFSF11	0	CEP126	0	two hybrid	Vinayagam A (2011)	1
AIMP2	0	OFD1	3	affinity chromatography technology	Boldt K (2016)	1
DISC1	6	ROGDI	1	two hybrid	Camargo LM (2007)	1
PRKRA	0	STAU2	4	affinity chromatography technology, affinity chromatography technology	Li S (2014), Li S (2014)	2
PPP1CC	2	LRRC1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	3
FGFR3	7	CEP126	0	two hybrid	Stelzl U (2005)	1
YWHAZ	1	CEP126	0	two hybrid	Stelzl U (2005)	1
PIK3R3	0	LUC7L2	0	two hybrid	Vinayagam A (2011)	1
EPN1	4	CEP126	0	two hybrid	Stelzl U (2005)	1
NPM3	2	CEP126	0	two hybrid	Stelzl U (2005)	1
PRKRA	0	CEP126	0	two hybrid	Vinayagam A (2011)	1
NAT9	1	CEP126	0	two hybrid	Stelzl U (2005)	1
AKTIP	3	CEP126	0	two hybrid	Stelzl U (2005)	1
TTR	0	CEP126	0	two hybrid	Vinayagam A (2011)	1
FAM118B	0	CEP126	0	two hybrid	Vinayagam A (2011)	1
AIMP2	0	CEP126	0	two hybrid	Vinayagam A (2011)	1
EIF2S2	0	CEP126	0	two hybrid	Stelzl U (2005)	1
ATRX	7	POLD1	5	affinity chromatography technology	Boldt K (2016)	1
ARIH2	4	CEP126	0	two hybrid	Stelzl U (2005)	1
HMOX2	0	CEP126	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
C11orf58	0	CEP126	0	two hybrid	Vinayagam A (2011)	1
OFD1	3	LUC7L2	0	two hybrid	Stelzl U (2005)	1
NAP1L5	1	LUC7L2	0	two hybrid	Stelzl U (2005)	1
NSF	3	LUC7L2	0	two hybrid	Stelzl U (2005)	1
RETREG2	2	CEP126	0	two hybrid	Stelzl U (2005)	1
NUDT21	0	CEP126	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
LRRC1	1	CEP126	0	two hybrid	Stelzl U (2005)	1
BRD1	5	YWHAZ	1	affinity chromatography technology	Fryland T (2016)	1
LUC7L2	0	CEP126	0	two hybrid	Stelzl U (2005)	1
TXNDC9	0	CEP126	0	two hybrid	Stelzl U (2005)	1
DNM1	21	NPM3	2	biochemical	Kristensen AR (2012)	1
EIF6	2	OFD1	3	two hybrid	Stelzl U (2005)	1
ATRX	7	LUC7L2	0	two hybrid	Stelzl U (2005)	1
PPP1CC	2	PPP1CA	3	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Huttlin EL (2015), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Boldt K (2016), Yadav L (2017), Yadav L (2017), Yadav L (2017)	8
KLHL20	2	EIF2S2	0	affinity chromatography technology	Huttlin EL (2015)	1
PMF1	0	PPP1CC	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CSTF2	2	CEP126	0	two hybrid	Stelzl U (2005)	1
RPA2	0	EIF2S2	0	affinity chromatography technology	Marechal A (2014)	1
RGS2	2	CEP126	0	two hybrid	Vinayagam A (2011)	1
ZBED8	1	CEP126	0	two hybrid	Vinayagam A (2011)	1
FXR1	0	LUC7L2	0	two hybrid	Stelzl U (2005)	1
FXR1	0	CEP126	0	two hybrid	Stelzl U (2005)	1
POLR2M	0	CEP126	0	two hybrid	Stelzl U (2005)	1
ODF2L	4	CEP126	0	two hybrid	Stelzl U (2005)	1
MAD2L1BP	0	CEP126	0	two hybrid	Stelzl U (2005)	1
RPA2	0	PPP1CC	2	affinity chromatography technology	Marechal A (2014)	1
LPL	3	CEP126	0	two hybrid	Stelzl U (2005)	1
PPP1CA	3	TFG	3	affinity chromatography technology	Cid C (2007)	1
EIF2S2	0	RAN	1	affinity chromatography technology	Trakman L (2016)	1
SPDL1	2	CEP126	0	two hybrid	Stelzl U (2005)	1
OFD1	3	RUVBL1	2	affinity chromatography technology, pull down	Giorgio G (2007), Giorgio G (2007)	2
NSF	3	CEP126	0	two hybrid	Stelzl U (2005)	1
CDKN2B	0	CEP126	0	two hybrid	Stelzl U (2005)	1
BMI1	0	PRKRA	0	affinity chromatography technology	Cao Q (2014)	1
DISC1	6	ARIH2	4	two hybrid	Camargo LM (2007)	1
CSTF2	2	GET4	3	biochemical	Kristensen AR (2012)	1
GEMIN7	0	CEP126	0	two hybrid	Vinayagam A (2011)	1
DNM1	21	CEP126	0	two hybrid	Stelzl U (2005)	1
POLD1	5	CEP126	0	two hybrid	Stelzl U (2005)	1
STAU2	4	CEP126	0	two hybrid	Stelzl U (2005)	1
RAB27A	0	CEP126	0	two hybrid	Stelzl U (2005)	1
DLEU1	0	CEP126	0	two hybrid	Stelzl U (2005)	1
NAT9	1	LUC7L2	0	two hybrid	Stelzl U (2005)	1
PPP1CA	3	LRRC1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), St-Denis N (2016), Huttlin EL (2017)	3