PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EP300	36	SMAD3	1	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Qiu P (2006), Furumatsu T (2005), Itoh S (2000), Akiyoshi S (1999), Abecassis L (2004), Kaimori A (2010), Janknecht R (1998), Janknecht R (1998), Nishihara A (1999), Nishihara A (1999), Furumatsu T (2005), Ghosh AK (2004), Shen X (1998), Shen X (1998), Ghosh AK (2001), Postigo AA (2003), Postigo AA (2003), Yang WS (2005), Lim JY (2012), Lim JY (2012), Jinnin M (2007), Wang G (2005)	22
BCL7A	3	MKL1	2	affinity chromatography technology	Huttlin EL (2017)	1
KDM3A	11	MKL2	5	pull down	Lockman K (2007)	1
ACTB	8	EP300	36	two hybrid	Wang J (2011)	1
MKL1	2	SRF	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Selvaraj A (2003), Zhang M (2007), Zhang M (2007), Charbonney E (2011), Philippar U (2004)	5
LCA5	1	MKL1	2	bioid	Gupta GD (2015)	1
NCOA3	3	MKL1	2	pull down	Li HJ (2007)	1
MKL1	2	SUPT16H	4	affinity chromatography technology	Kihara T (2008)	1
SMAD3	1	MYOCD	4	affinity chromatography technology, pull down	Qiu P (2005), Qiu P (2005)	2
SMAD3	1	NCOA3	3	affinity chromatography technology	Xi Q (2008)	1
TRIM25	5	EP300	36	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
BCL7A	3	MKL2	5	affinity chromatography technology	Huttlin EL (2017)	1
MKL1	2	ACTB	8	affinity chromatography technology	Hu Q (2011)	1
XPO1	8	NCOA3	3	affinity chromatography technology	Kirli K (2015)	1
MKL2	5	SRF	1	affinity chromatography technology	Selvaraj A (2003)	1
MYOCD	4	MKL1	2	pull down	Du KL (2004)	1
KIAA0753	1	MKL1	2	bioid	Gupta GD (2015)	1
MKL1	2	GSK3B	1	affinity chromatography technology	Charbonney E (2011)	1
NCOA3	3	MKL2	5	pull down	Li HJ (2007)	1
SSRP1	1	SUPT16H	4	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology	Birch JL (2009), Tan BC (2006), Tan BC (2006), Pavri R (2006), Huang JY (2006), Huang JY (2006), OConnell BC (2010), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Huttlin EL (2017), Boldt K (2016)	12
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
SMARCA4	19	ACTB	8	affinity chromatography technology, affinity chromatography technology, biochemical	Zhao K (1998), Xu YZ (2011), Nishimoto N (2012)	3
MKL1	2	SMAD3	1	affinity chromatography technology	Charbonney E (2011)	1
TCTN1	2	MKL1	2	bioid	Gupta GD (2015)	1
GSK3B	1	NCOA3	3	enzymatic study	Wu RC (2004)	1
CEP19	0	MKL1	2	bioid	Gupta GD (2015)	1
SMARCA4	19	MYOCD	4	affinity chromatography technology, affinity chromatography technology, pull down	Zhou J (2009), Zhou J (2009), Zhou J (2009)	3
XPO1	8	MKL1	2	affinity chromatography technology	Kirli K (2015)	1
NXF1	0	SUPT16H	4	affinity chromatography technology	Castello A (2012)	1
TRIM25	5	SMAD3	1	affinity chromatography technology	Choudhury NR (2017)	1
KDM3A	11	MKL1	2	pull down, pull down	Lockman K (2007), Lockman K (2007)	2
DNMT1	5	MKL1	2	affinity chromatography technology	Xing WJ (2015)	1
TRIM25	5	MKL1	2	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	SUPT16H	4	affinity chromatography technology	Choudhury NR (2017)	1
TRIM25	5	XPO1	8	affinity chromatography technology	Choudhury NR (2017)	1
SMAD3	1	ACTB	8	affinity chromatography technology	Grimsby S (2004)	1
SMARCA4	19	SRF	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhou J (2009), Zhou J (2009), Zhang M (2007)	3
XPO1	8	SSRP1	1	affinity chromatography technology	Kirli K (2015)	1
SMARCA4	19	BCL7A	3	affinity chromatography technology, biochemical, affinity chromatography technology	Tando T (2010), Wan C (2015), Huttlin EL (2017)	3
GSK3B	1	DNMT1	5	two hybrid	Vinayagam A (2011)	1
CEP63	2	KIAA0753	1	bioid, bioid, affinity chromatography technology, bioid	Firat-Karalar EN (2014), Firat-Karalar EN (2014), Firat-Karalar EN (2014), Gupta GD (2015)	4
NXF1	0	MKL1	2	affinity chromatography technology	Castello A (2012)	1
XPO1	8	GSK3B	1	affinity chromatography technology	Kirli K (2015)	1
KDM3A	11	MYOCD	4	pull down	Lockman K (2007)	1
MVP	1	MKL1	2	two hybrid	Corominas R (2014)	1
CEP63	2	MKL1	2	bioid	Gupta GD (2015)	1
SRF	1	SSRP1	1	affinity chromatography technology	Spencer JA (1999)	1
SMAD3	1	SMARCA4	19	affinity chromatography technology, affinity chromatography technology	Xi Q (2008), Xi Q (2008)	2
TRIM25	5	SMARCA4	19	affinity chromatography technology	Choudhury NR (2017)	1
MKL1	2	SSRP1	1	affinity chromatography technology	Kihara T (2008)	1
MKL1	2	SMARCA4	19	affinity chromatography technology, pull down	Zhang M (2007), Zhang M (2007)	2
LCA5	1	KIAA0753	1	affinity chromatography technology, bioid	Gupta GD (2015), Gupta GD (2015)	2
MYOCD	4	NCOA3	3	affinity chromatography technology, affinity chromatography technology, genetic interference, pull down, genetic interference	Li HJ (2007), Li HJ (2007), Li HJ (2007), Li HJ (2007), Li HJ (2007)	5
MYOCD	4	SRF	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Wang Z (2004), Zhou J (2009), Zhou J (2009), Li HJ (2007)	4
MKL1	2	EP300	36	affinity chromatography technology, affinity chromatography technology	He H (2015), He H (2015)	2
GSK3B	1	SMAD3	1	affinity chromatography technology, pull down, affinity chromatography technology	Guo X (2008), Guo X (2008), Choi SI (2011)	3
NCOA3	3	EP300	36	affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, pull down, imaging technique, two hybrid, enzymatic study, affinity chromatography technology, pull down	Pao GM (2000), Feng Q (2006), Demarest SJ (2002), Demarest SJ (2002), Arimura A (2004), Font de Mora J (2000), Wang F (2010), Yi P (2005), Chen H (1999), Yi P (2015), Yi P (2015)	11
XPO1	8	MKL2	5	affinity chromatography technology	Kirli K (2015)	1
MKL1	2	MKL2	5	affinity chromatography technology	Selvaraj A (2003)	1
RPGRIP1	6	MKL1	2	bioid	Gupta GD (2015)	1