PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TAF1D	0	FEZ1	0	two hybrid	Vinayagam A (2011)	1
SSR1	1	ATP5C1	0	biochemical	Wan C (2015)	1
PPP2CA	7	PTN	0	two hybrid	Stelzl U (2005)	1
PLXNB2	14	PTN	0	two hybrid	Stelzl U (2005)	1
PSMD2	2	UBQLN1	1	biochemical	Havugimana PC (2012)	1
PTN	0	GPRASP2	0	two hybrid	Goehler H (2004)	1
PTPRS	15	FEZ1	0	two hybrid	Stelzl U (2005)	1
TXNDC9	0	CHD3	19	two hybrid	Stelzl U (2005)	1
PTN	0	TSC22D1	1	two hybrid	Wang J (2011)	1
UTP3	0	PTN	0	two hybrid	Stelzl U (2005)	1
LUC7L2	0	PTN	0	two hybrid	Stelzl U (2005)	1
BMI1	0	CAPZB	2	affinity chromatography technology	Cao Q (2014)	1
GSK3B	1	BAG6	2	two hybrid	Vinayagam A (2011)	1
GADD45A	1	CHD3	19	two hybrid	Vinayagam A (2011)	1
MRPL44	3	PTN	0	two hybrid	Vinayagam A (2011)	1
GIPC2	2	PTN	0	two hybrid	Stelzl U (2005)	1
CRCT1	1	PTN	0	two hybrid	Stelzl U (2005)	1
PTN	0	PTPRZ1	3	affinity chromatography technology, imaging technique	Meng K (2000), Koutsioumpa M (2015)	2
WFDC2	2	PTN	0	two hybrid	Stelzl U (2005)	1
C11orf58	0	PTN	0	two hybrid	Vinayagam A (2011)	1
WASHC3	2	LUC7L2	0	two hybrid	Stelzl U (2005)	1
BMI1	0	ATRX	7	affinity chromatography technology, biochemical	Abdouh M (2016), Abdouh M (2016)	2
CRELD1	0	PTN	0	two hybrid	Stelzl U (2005)	1
GTF2F1	0	PTN	0	two hybrid	Stelzl U (2005)	1
NUDT21	0	RPLP1	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
BTBD2	4	PTN	0	two hybrid	Stelzl U (2005)	1
KPNB1	3	PTN	0	two hybrid	Goehler H (2004)	1
PSMD11	0	PSMD2	2	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
GSTP1	0	PTN	0	two hybrid	Stelzl U (2005)	1
MYCBP	0	PTN	0	two hybrid	Stelzl U (2005)	1
EVA1A	0	PTN	0	two hybrid	Stelzl U (2005)	1
SUPT7L	2	PTN	0	two hybrid	Stelzl U (2005)	1
SNCAIP	2	PTN	0	two hybrid	Stelzl U (2005)	1
TAC3	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
PFDN1	0	PTN	0	two hybrid	Vinayagam A (2011)	1
TXNDC9	0	FEZ1	0	two hybrid, affinity chromatography technology	Stelzl U (2005), Stelzl U (2005)	2
ARL15	0	PTN	0	two hybrid	Stelzl U (2005)	1
SLC25A36	0	PTN	0	two hybrid	Stelzl U (2005)	1
BCL2L1	0	TP53BP2	5	two hybrid, unspecified method, x-ray crystallography	Vinayagam A (2011), Katz C (2008), Katz C (2008)	3
RIT1	1	MAD2L1BP	0	affinity chromatography technology	Huttlin EL (2017)	1
PSMD2	2	PTN	0	two hybrid	Stelzl U (2005)	1
BARD1	4	KPNB1	3	affinity chromatography technology	Woods NT (2012)	1
BCL2L1	0	PTN	0	two hybrid	Vinayagam A (2011)	1
LUC7L2	0	FTL	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TOMM20	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
GLYAT	3	PTN	0	two hybrid	Stelzl U (2005)	1
TOMM20	0	PTN	0	two hybrid	Stelzl U (2005)	1
NUDT21	0	SNCAIP	2	two hybrid	Vinayagam A (2011)	1
GSK3B	1	PTN	0	two hybrid	Vinayagam A (2011)	1
TXNDC9	0	NUDT21	0	biochemical	Wan C (2015)	1
BARD1	4	CHD3	19	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
CTNNB1	30	GSK3B	1	affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Davies G (2001), Kishida S (1999), Fischer L (2002), Kitagawa M (1999), Hart M (1999), Su Y (2008), Huang X (2009), Ding Q (2005), Piao S (2008), Varjosalo M (2013), Gao C (2014), Koo J (2015), Chen TC (2014), Lu D (2012), Kuslansky Y (2016), Novellasdemunt L (2017), Lu WJ (2015)	17
PPP2CA	7	RACK1	2	affinity chromatography technology	Peng D (2017)	1
SAT1	0	LUC7L2	0	two hybrid	Stelzl U (2005)	1
TAF1D	0	PTN	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
EIF3F	1	PTN	0	two hybrid	Stelzl U (2005)	1
NUDT21	0	PTN	0	two hybrid	Vinayagam A (2011)	1
DNAJB11	3	UBQLN4	2	two hybrid	Vinayagam A (2011)	1
PTN	0	PTN	0	two hybrid	Goehler H (2004)	1
UBQLN1	1	P4HB	1	two hybrid, affinity chromatography technology, pull down	Ko HS (2002), Ko HS (2002), Ko HS (2002)	3
GPD1	2	PTN	0	two hybrid	Stelzl U (2005)	1
PTN	0	CTNNB1	30	affinity chromatography technology	Meng K (2000)	1
BMI1	0	RACK1	2	affinity chromatography technology	Cao Q (2014)	1
PSMD11	0	PTN	0	two hybrid	Stelzl U (2005)	1
CDK5RAP2	3	PTN	0	two hybrid	Stelzl U (2005)	1
GTF2F1	0	FEZ1	0	two hybrid	Stelzl U (2005)	1
GSK3B	1	BCL2L1	0	enzymatic study	Wang J (2012)	1
LUC7L2	0	CHD3	19	two hybrid	Stelzl U (2005)	1
PTPRZ1	3	CTNNB1	30	affinity chromatography technology	Meng K (2000)	1
SAT1	0	RPLP1	0	two hybrid	Stelzl U (2005)	1
WASHC3	2	BLOC1S1	0	affinity chromatography technology	Huttlin EL (2017)	1
BMI1	0	PTN	0	two hybrid	Stelzl U (2005)	1
PFDN1	0	PPP2CA	7	biochemical	Kristensen AR (2012)	1
ATRX	7	PTN	0	two hybrid	Stelzl U (2005)	1
STC2	0	PTN	0	two hybrid	Stelzl U (2005)	1
TXNDC9	0	PTN	0	two hybrid	Stelzl U (2005)	1
ARIH2	4	PTN	0	two hybrid	Stelzl U (2005)	1
MAD2L1BP	0	PTN	0	two hybrid	Stelzl U (2005)	1
NAP1L5	1	PTN	0	two hybrid	Stelzl U (2005)	1
CGA	0	PTN	0	two hybrid	Stelzl U (2005)	1
C7orf25	0	PTN	0	two hybrid	Vinayagam A (2011)	1
BMI1	0	KPNB1	3	affinity chromatography technology	Abdouh M (2016)	1
GSK3B	1	CHD3	19	two hybrid	Vinayagam A (2011)	1
SAT1	0	EVA1A	0	two hybrid	Stelzl U (2005)	1
SSR1	1	PTN	0	two hybrid	Stelzl U (2005)	1
KPNB1	3	PIAS4	5	two hybrid	Goehler H (2004)	1
CACNB4	0	PTN	0	two hybrid	Stelzl U (2005)	1
SAT1	0	PTN	0	two hybrid	Stelzl U (2005)	1
PTPRS	15	CHD3	19	two hybrid	Stelzl U (2005)	1
PTN	0	PIAS4	5	two hybrid	Goehler H (2004)	1
GSK3B	1	LUC7L2	0	two hybrid	Vinayagam A (2011)	1
NEK6	2	PSMD2	2	affinity chromatography technology	Ewing RM (2007)	1
GSK3B	1	SNCAIP	2	enzymatic study, affinity chromatography technology	Avraham E (2005), Avraham E (2005)	2
BARD1	4	LUC7L2	0	affinity chromatography technology	Woods NT (2012)	1
LAMA4	8	PTN	0	two hybrid	Stelzl U (2005)	1
PPP2CA	7	KPNB1	3	affinity chromatography technology	Glatter T (2009)	1
UBQLN1	1	BAG6	2	affinity chromatography technology, affinity chromatography technology	Kurlawala Z (2017), Kurlawala Z (2017)	2
BARD1	4	BCCIP	1	two hybrid	Woods NT (2012)	1
PSMB10	0	PTN	0	two hybrid	Stelzl U (2005)	1
BARD1	4	FEZ1	0	two hybrid	Goehler H (2004)	1
CHD3	19	KPNB1	3	two hybrid	Goehler H (2004)	1
ALK	8	RACK1	2	affinity chromatography technology	Ambrogio C (2005)	1
RBM23	0	PTN	0	two hybrid	Stelzl U (2005)	1
APOBEC3G	1	PTN	0	two hybrid	Stelzl U (2005)	1
UBQLN4	2	BAG6	2	two hybrid, affinity chromatography technology	Lim J (2006), Suzuki R (2016)	2
NAP1L5	1	LUC7L2	0	two hybrid	Stelzl U (2005)	1
HGH1	0	PTN	0	two hybrid	Stelzl U (2005)	1
GSDME	0	PTN	0	two hybrid	Stelzl U (2005)	1
P4HB	1	PTN	0	two hybrid	Stelzl U (2005)	1
FTL	0	PTN	0	two hybrid	Stelzl U (2005)	1
BARD1	4	GPRASP2	0	two hybrid	Goehler H (2004)	1
PTN	0	UBQLN1	1	two hybrid	Wang J (2011)	1
WASHC3	2	PTN	0	two hybrid	Stelzl U (2005)	1
GADD45A	1	PTN	0	two hybrid	Vinayagam A (2011)	1
BARD1	4	PTN	0	two hybrid	Goehler H (2004)	1
SGSM2	2	CHD3	19	two hybrid	Stelzl U (2005)	1
PTPRB	4	PTN	0	imaging technique	Koutsioumpa M (2015)	1
BMI1	0	P4HB	1	affinity chromatography technology	Cao Q (2014)	1
PFDN1	0	RPLP1	0	two hybrid	Stelzl U (2005)	1
CTNNB1	30	CDH10	1	affinity chromatography technology, affinity chromatography technology	Shimoyama Y (2000), Hein MY (2015)	2
UBQLN4	2	PTN	0	two hybrid, two hybrid	Stelzl U (2005), Lim J (2006)	2
ATP5C1	0	PTN	0	two hybrid	Stelzl U (2005)	1
SAT1	0	CHD3	19	two hybrid	Stelzl U (2005)	1
DUSP12	1	PTN	0	two hybrid	Stelzl U (2005)	1
CDH10	1	PTN	0	two hybrid	Stelzl U (2005)	1
TBRG4	4	PTN	0	two hybrid	Stelzl U (2005)	1
ATRX	7	LUC7L2	0	two hybrid	Stelzl U (2005)	1
GSK3B	1	RPLP1	0	two hybrid	Vinayagam A (2011)	1
SGTA	1	PTN	0	two hybrid, two hybrid	Stelzl U (2005), Wang J (2011)	2
BMI1	0	CHD3	19	affinity chromatography technology	Cao Q (2014)	1
RACK1	2	SAT1	0	pull down	Baek JH (2007)	1
SGTA	1	BAG6	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, pull down	Winnefeld M (2006), Xu Y (2012), Xu Y (2012), Xu Y (2012), Leznicki P (2013), Taipale M (2014), Taipale M (2014), Rolland T (2014), Darby JF (2014), Darby JF (2014), Darby JF (2014), Liu Y (2014), Krysztofinska EM (2016), Krysztofinska EM (2016)	14
ITSN2	7	BCCIP	1	two hybrid	Stelzl U (2005)	1
PFDN1	0	PLXNB2	14	two hybrid	Vinayagam A (2011)	1
BAG6	2	PTN	0	two hybrid	Wang J (2011)	1
BCCIP	1	PTN	0	two hybrid	Stelzl U (2005)	1
RACK1	2	PTN	0	two hybrid	Stelzl U (2005)	1
TSC22D1	1	BAG6	2	affinity chromatography technology	Ewing RM (2007)	1
PTN	0	CHD3	19	two hybrid, two hybrid	Stelzl U (2005), Goehler H (2004)	2
PMF1	0	PTN	0	two hybrid	Stelzl U (2005)	1
P4HB	1	FEZ1	0	two hybrid	Stelzl U (2005)	1
PSMD2	2	UBQLN4	2	affinity chromatography technology, affinity chromatography technology	Li X (2008), Su V (2013)	2
TP53BP2	5	PTN	0	two hybrid	Stelzl U (2005)	1
BMI1	0	RPLP1	0	affinity chromatography technology	Cao Q (2014)	1
RIT1	1	PTN	0	two hybrid	Stelzl U (2005)	1
C11orf58	0	SNCAIP	2	two hybrid	Vinayagam A (2011)	1
TAC3	0	PTN	0	two hybrid	Stelzl U (2005)	1
GADD45G	0	LUC7L2	0	two hybrid, two hybrid	Vinayagam A (2011), Goehler H (2004)	2
RPLP1	0	PTN	0	two hybrid	Stelzl U (2005)	1
MKKS	1	PTN	0	two hybrid	Stelzl U (2005)	1
CAPZB	2	PTN	0	two hybrid	Stelzl U (2005)	1
CHD3	19	PIAS4	5	two hybrid	Goehler H (2004)	1
GADD45A	1	GADD45G	0	affinity chromatography technology	Kovalsky O (2001)	1
HSPBAP1	1	PTN	0	two hybrid	Stelzl U (2005)	1
BARD1	4	PIAS4	5	two hybrid	Goehler H (2004)	1
TOMM20	0	BAG6	2	two hybrid	Stelzl U (2005)	1
CDK5RAP2	3	LUC7L2	0	two hybrid	Stelzl U (2005)	1
TSC22D1	1	CHD3	19	two hybrid	Vinayagam A (2011)	1
PTN	0	FEZ1	0	two hybrid	Goehler H (2004)	1
PTN	0	GADD45G	0	two hybrid	Goehler H (2004)	1
KPNB1	3	C11orf58	0	biochemical	Wan C (2015)	1
SGSM2	2	PTN	0	two hybrid	Stelzl U (2005)	1
C11orf58	0	RPLP1	0	two hybrid	Vinayagam A (2011)	1
NEK6	2	PTN	0	two hybrid, pull down, enzymatic study	Vaz Meirelles G (2010), Vaz Meirelles G (2010), Vaz Meirelles G (2010)	3
COX6C	1	PTN	0	two hybrid	Stelzl U (2005)	1
CAAP1	0	PTN	0	two hybrid	Stelzl U (2005)	1
CRCT1	1	CHD3	19	two hybrid	Stelzl U (2005)	1
CYP2E1	0	PTN	0	two hybrid	Wang J (2011)	1
MLLT3	0	PTN	0	two hybrid	Stelzl U (2005)	1
ITSN2	7	PTN	0	two hybrid	Stelzl U (2005)	1
DNAJB11	3	BAG6	2	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
BLOC1S1	0	PTN	0	two hybrid	Stelzl U (2005)	1
DNAJB11	3	PTN	0	two hybrid, two hybrid	Stelzl U (2005), Vinayagam A (2011)	2
UBQLN4	2	UBQLN1	1	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology	Lim J (2006), Havugimana PC (2012), Lee DY (2013), Lee DY (2013)	4
PTPRS	15	PTN	0	two hybrid	Stelzl U (2005)	1
GADD45G	0	PIAS4	5	two hybrid	Goehler H (2004)	1
ALK	8	PTN	0	pull down	Stoica GE (2001)	1
GADD45A	1	BAG6	2	two hybrid	Vinayagam A (2011)	1
CAPZB	2	BCCIP	1	two hybrid	Stelzl U (2005)	1