PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ABL1	9	EEF1G	0	affinity chromatography technology	So J (2015)	1
CCNG1	1	PLEKHA4	4	two hybrid	Wang J (2011)	1
ABL1	9	PLEKHA4	4	two hybrid	Daakour S (2016)	1
PLEKHA4	4	KAT5	1	two hybrid	Stelzl U (2005)	1
PLEKHA4	4	EEF1G	0	two hybrid	Stelzl U (2005)	1
PLEKHA4	4	LRIF1	3	two hybrid	Stelzl U (2005)	1
SETDB1	3	LRIF1	3	two hybrid	Goehler H (2004)	1
PTPN11	20	PLEKHA4	4	two hybrid	Daakour S (2016)	1
PLEKHA4	4	SETDB1	3	two hybrid	Stelzl U (2005)	1
KAT5	1	LRIF1	3	two hybrid	Goehler H (2004)	1
PLEKHA4	4	PRKAA1	2	two hybrid	Wang J (2011)	1