PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PRX	3	DAG1	3	affinity chromatography technology	Sherman DL (2001)	1
TERF2IP	1	PRX	3	two hybrid	Lee OH (2011)	1
EZR	8	PRX	3	affinity chromatography technology	Straub BK (2003)	1
PRX	3	PRX	3	two hybrid, affinity chromatography technology, pull down	Sherman DL (2001), Sherman DL (2001), Sherman DL (2001)	3
CDK6	0	PRX	3	enzymatic study	Anders L (2011)	1
DRP2	0	PRX	3	pull down, affinity chromatography technology	Sherman DL (2001), Sherman DL (2001)	2
DRP2	0	DAG1	3	two hybrid	Sherman DL (2001)	1