PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ZFYVE28	7	RAB4A	0	imaging technique	Mosesson Y (2009)	1
RAB7A	0	RAB5A	0	two hybrid, biochemical, biochemical	Bucci C (1999), Havugimana PC (2012), Wan C (2015)	3
RAB7A	0	RAB4A	0	two hybrid	Bucci C (1999)	1
ZFYVE28	7	RAB7A	0	imaging technique	Mosesson Y (2009)	1
PRNP	4	ZFYVE28	7	pull down	Satoh J (2009)	1
ZFYVE28	7	EGFR	5	imaging technique	Mosesson Y (2009)	1
ZFYVE28	7	EGF	2	imaging technique	Mosesson Y (2009)	1
RAB4A	0	RAB5A	0	biochemical	Vitale G (1998)	1
EGF	2	EGFR	5	pull down, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, x-ray crystallography, x-ray crystallography, pull down, pull down, pull down, imaging technique	Stortelers C (2002), Wong L (1999), Tong J (2009), Tong J (2008), Chen TC (2014), Gomez-Suaga P (2014), Ogiso H (2002), Ferguson KM (2003), Ferguson KM (2003), Bessman NJ (2014), Zheng Y (2015), Latha K (2013)	12
ZFYVE28	7	RAB5A	0	imaging technique	Mosesson Y (2009)	1