Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
TRIB3	rs2295490	G	methylphenidate	efficacy	no	The authors carried out a GWAS in a Spanish cohort of pediatric patients, than performed a meta-analysis using data from the Spanish cohort and data from a Brazilian adult patient cohort. This variant was not significant in the meta-analysis after Bonferroni correction had been applied, and was nominally significant (i.e did not reach genome-wide significance) in the initial GWAS in the Spanish cohort. Response was measured on the Clinical Global Impression-Improvement scale (CGI-I). A CGI-I score of two points or less after eight weeks of treatment was considered a good response.	Allele G is associated with increased response to methylphenidate in people with Attention Deficit Disorder with Hyperactivity.	29382897	1449166094
TRIB3	rs2295490	AA	indapamide	efficacy	no	SBP presented no remarkable difference between AA and AG+GG genotype groups. In the group receiving therapy, AA genotype carriers had a mean decrease of DBP of 0.8mmHg. No difference was seen in SBP.	Genotype AA is associated with increased response to indapamide and perindopril in people with Diabetes Mellitus, Type 2 as compared to genotypes AG + GG.	27793583	1448602034