PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
XPO5	2	PDIA6	1	biochemical	Kristensen AR (2012)	1
PTPRE	1	CSE1L	1	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
EGFR	5	XPO5	2	affinity chromatography technology	Foerster S (2013)	1
GABARAPL2	0	PTPRA	3	two hybrid	Vinayagam A (2011)	1
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
PTPRA	3	BASP1	1	bioid	St-Denis N (2016)	1
EGFR	5	PTPRA	3	two hybrid, affinity chromatography technology	Yao Z (2017), Yao Z (2017)	2
HSPB1	2	PTPRA	3	two hybrid	Katsogiannou M (2014)	1
PTPRA	3	NCDN	4	affinity chromatography technology	Li X (2016)	1
PTPRA	3	TXNDC5	5	affinity chromatography technology	Li X (2016)	1
PTPRA	3	PSAT1	1	affinity chromatography technology	St-Denis N (2016)	1
HSPB1	2	EPB41L1	4	two hybrid	Katsogiannou M (2014)	1
PTPRA	3	TMEM51	2	bioid	St-Denis N (2016)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
PTPRA	3	TNPO3	16	affinity chromatography technology	Li X (2016)	1
EGFR	5	XPO6	2	affinity chromatography technology	Foerster S (2013)	1
PTPRA	3	B4GAT1	2	affinity chromatography technology	Li X (2016)	1
EGFR	5	BAIAP2	6	two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014), Li J (2013)	4
LGALS8	4	PTPRG	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTPRA	3	GRB2	2	affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	den Hertog J (1996), den Hertog J (1996), den Hertog J (1994), den Hertog J (1994), Zheng XM (2002), Brehme M (2009), Li J (2013), St-Denis N (2016), St-Denis N (2016), Huttlin EL (2017), Wang J (2013), Wang J (2013)	12
PTPRE	1	SAAL1	0	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
PTPRA	3	GAB1	3	bioid	St-Denis N (2016)	1
PTPRA	3	LGALS1	1	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	NCDN	4	affinity chromatography technology	Foerster S (2013)	1
PTPRA	3	PDIA6	1	affinity chromatography technology	Li X (2016)	1
PTPRA	3	EPB41L1	4	bioid	St-Denis N (2016)	1
PDIA6	1	CANX	4	biochemical	Wan C (2015)	1
PTPRA	3	MBP	0	enzymatic study	Wang J (2013)	1
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
EGFR	5	YWHAZ	1	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Tong J (2009), Foerster S (2013), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
EGFR	5	LGALS8	4	affinity chromatography technology	Foerster S (2013)	1
PTPRA	3	ATXN2	3	affinity chromatography technology	St-Denis N (2016)	1
EGFR	5	ATXN2	3	affinity chromatography technology, affinity chromatography technology	Nonis D (2008), Nonis D (2008)	2
PTPRA	3	XPO5	2	affinity chromatography technology	Li X (2016)	1
PTPRE	1	XPOT	1	affinity chromatography technology	St-Denis N (2016)	1
PTPRG	4	PSD3	4	bioid	St-Denis N (2016)	1
PTPRA	3	PTPRG	4	affinity chromatography technology	Wang J (2013)	1
GRB2	2	YWHAZ	1	affinity chromatography technology	Bisson N (2011)	1
EGFR	5	LGALS1	1	affinity chromatography technology, affinity chromatography technology	Guo HB (2009), Foerster S (2013)	2
CCDC88A	3	EGFR	5	imaging technique	Simpson F (2005)	1
EGFR	5	TNPO3	16	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
ERBB2	6	CCDC88A	3	affinity chromatography technology	Hein MY (2015)	1
PTPRE	1	BAIAP2	6	bioid	St-Denis N (2016)	1
PTPRA	3	XPOT	1	affinity chromatography technology	Li X (2016)	1
TXNDC5	5	CSE1L	1	biochemical	Havugimana PC (2012)	1
PTPRA	3	ARL2	0	affinity chromatography technology	St-Denis N (2016)	1
HSPB1	2	PSAT1	1	biochemical	Wan C (2015)	1
ERBB2	6	GAB1	3	enzymatic study	Fan YX (2013)	1
PTPRA	3	GALNT12	0	affinity chromatography technology	Huttlin EL (2017)	1
NF2	1	EGFR	5	affinity chromatography technology, fluorescent resonance energy transfe	Guerrero PA (2015), Ivanov AA (2017)	2
PTPRA	3	CCDC88A	3	bioid	St-Denis N (2016)	1
PTPRA	3	TNPO1	1	affinity chromatography technology	Li X (2016)	1
PTPRA	3	RAPH1	3	bioid	St-Denis N (2016)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
SRC	2	ERBB2	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Ren Z (2002), Li X (2007), Liang K (2010), Liang K (2010), Shen JP (2017)	5
PTPRA	3	KCNMA1	10	affinity chromatography technology	St-Denis N (2016)	1
PTPRA	3	CANX	4	affinity chromatography technology	Li X (2016)	1
GRB2	2	PTPRE	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Toledano-Katchalski H (1999), St-Denis N (2016), Yadav L (2017)	3
PTPRA	3	ASNSD1	2	affinity chromatography technology	Huttlin EL (2017)	1
EGFR	5	XPOT	1	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Tong J (2014)	2
PTPRA	3	EXOC3	2	bioid	St-Denis N (2016)	1
SP4	4	PTPRA	3	affinity chromatography technology	Huttlin EL (2017)	1
FYN	1	PTPRA	3	affinity chromatography technology	Bhandari V (1998)	1
ERBB2	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Schulze WX (2006), Bourguignon LY (2001), Olayioye MA (1998), Li X (2007), Li X (2007), Crovello CS (1998), Jones RB (2006)	7
UVRAG	2	PTPRA	3	affinity chromatography technology	Behrends C (2010)	1
SRC	2	PTPRA	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zheng XM (2002), Wang J (2013), Wang J (2013)	3
YWHAZ	1	PTPRA	3	affinity chromatography technology	Hein MY (2015)	1
PTPRA	3	VPS25	1	affinity chromatography technology	St-Denis N (2016)	1
GABARAPL2	0	YWHAZ	1	two hybrid	Vinayagam A (2011)	1
PTPRE	1	TNPO1	1	affinity chromatography technology	Li X (2016)	1
PTPRA	3	NF2	1	bioid	St-Denis N (2016)	1
EGFR	5	GABARAPL2	0	protein complementation assay	Deribe YL (2009)	1
TNPO1	1	TNPO3	16	biochemical	Havugimana PC (2012)	1
ERBB2	6	PTPRA	3	affinity chromatography technology	Yao Z (2017)	1
PPP4R3A	3	PTPRA	3	affinity chromatography technology	Hein MY (2015)	1
FYN	1	KCNA2	6	affinity chromatography technology	Nitabach MN (2001)	1
PTPRA	3	PTPRA	3	affinity chromatography technology	Li X (2016)	1
HSPB1	2	YWHAZ	1	two hybrid	Katsogiannou M (2014)	1
KCNA2	6	PTPRA	3	affinity chromatography technology, pull down	Tsai W (1999), Tsai W (1999)	2
EGFR	5	TNPO1	1	affinity chromatography technology	Foerster S (2013)	1
PTPRA	3	XPO6	2	affinity chromatography technology	Li X (2016)	1
EGFR	5	CANX	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tong J (2014), Li J (2013), Yao Z (2017)	3
PTPRA	3	PSD3	4	bioid	St-Denis N (2016)	1
PTPRA	3	CYB561	2	affinity chromatography technology	Huttlin EL (2017)	1
PTPRA	3	GPRIN3	2	bioid	St-Denis N (2016)	1
PTPRE	1	XPO4	4	affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), Li X (2016)	2
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
PTPRA	3	CSE1L	1	affinity chromatography technology	Li X (2016)	1
LGALS8	4	PTPRA	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PTPRA	3	PTPRE	1	affinity chromatography technology, bioid, affinity chromatography technology, affinity chromatography technology	St-Denis N (2016), St-Denis N (2016), Huttlin EL (2017), Li X (2016)	4
PTPRA	3	DENND4A	8	affinity chromatography technology	Huttlin EL (2017)	1
PTPRA	3	XPO4	4	affinity chromatography technology	Li X (2016)	1
EGFR	5	CSE1L	1	affinity chromatography technology, affinity chromatography technology	Foerster S (2013), Yao Z (2017)	2
PTPRE	1	TNPO3	16	affinity chromatography technology	Li X (2016)	1
PTPRE	1	CANX	4	affinity chromatography technology, affinity chromatography technology	Li X (2016), Yadav L (2017)	2
NF2	1	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
PTPRA	3	BAIAP2	6	bioid	St-Denis N (2016)	1
PTPRA	3	CALM1	0	affinity chromatography technology	Liang L (2000)	1
PTPRA	3	NCBP1	7	affinity chromatography technology	St-Denis N (2016)	1
FCN1	2	PTPRG	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	SAAL1	0	affinity chromatography technology	Foerster S (2013)	1
FCN1	2	PTPRA	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
EGFR	5	EXOC3	2	affinity chromatography technology	Foerster S (2013)	1
EGFR	5	CALM1	0	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, pull down	Li H (2004), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Aifa S (2002)	5
PTPRG	4	NF2	1	bioid	St-Denis N (2016)	1
EGFR	5	GAB1	3	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, enzymatic study, affinity chromatography technology	Kameda H (2001), Tong J (2008), Kotlyar M (2015), Petschnigg J (2014), Lehr S (1999), Mueller KL (2012)	6
EGFR	5	HSPB1	2	affinity chromatography technology	Li J (2013)	1
ERBB2	6	TNPO1	1	affinity chromatography technology	Hein MY (2015)	1
EGFR	5	XPO4	4	affinity chromatography technology	Foerster S (2013)	1
PTPRA	3	TPCN2	0	affinity chromatography technology	Huttlin EL (2017)	1
GRB2	2	GAB1	3	affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, far western blotting, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Oneyama C (2002), Lewitzky M (2001), Lewitzky M (2001), Lewitzky M (2001), Holgado-Madruga M (1996), Holgado-Madruga M (1996), Holgado-Madruga M (1996), Bandyopadhyay S (2010), Ingham RJ (1998), Brehme M (2009), Fixman ED (1997), Bisson N (2011), Huttlin EL (2017), Kapoor GS (2010), Lehr S (1999)	15
PTPRA	3	SAAL1	0	affinity chromatography technology	Li X (2016)	1