Gene Name	Entrez ID	Drug Name	Chembl ID	Interaction Types	Sources	publications
PTPRD	5789	CUCURBITACIN I	CHEMBL387737		CIViC	26267899
PTPRD	5789	TEPROTUMUMAB	CHEMBL1743079		CIViC	23800680
PTPRD	5789	CIXUTUMUMAB	CHEMBL1743001		CIViC	23800680

Gene Name	Variant	Alleles	Chemical	Phenotype Category	Significance	Notes	Sentence	Publications	Annotation ID
PTPRD	rs17584499	CC	pioglitazone	efficacy	yes	Patients with the CC genotype showed significantly greater decreases in postprandial plasma glucose levels after 3 months of pioglitazone treatment. However, changes in other biochemical measures were not significant.	Genotype CC is associated with increased response to pioglitazone in people with Diabetes Mellitus, Type 2 as compared to genotypes CT + TT.	23147557	1450814910
PTPRD	rs324498	G	Antihypertensives	efficacy	no	The G allele was associated with increased odds of a patient developing resistant-hypertension. Participants were classified as having resistant hypertension if their SBP was ≥140 or DBP ≥ 90 using three or more medications, or if they were using four or greater antihypertensive medications regardless of BP. However, this SNP failed to reach genome-wide significance in either the INVEST or SPS3 cohorts or when both cohorts were combined. Additionally, this association could not be validated in an eMERGE dataset.	Allele G is associated with decreased response to Antihypertensives in people with Hypertension as compared to allele A.	30237584	1451100046
PTPRD	rs4742610	T	trandolapril	efficacy	yes	This was associated with resistant hypertension in whites and Hispanics in the international verapamil SR trandolapril study (meta-analysis P=3.2×10-5).	Allele T is associated with resistance to trandolapril and verapamil in people with Hypertension as compared to allele C.	26425837	1446902880