PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PTPRN2	8	HGS	5	bioid	St-Denis N (2016)	1
PTPRN2	8	GOLGA4	6	bioid	St-Denis N (2016)	1
CKAP5	2	HSPA5	0	affinity chromatography technology	Hein MY (2015)	1
PTPRN2	8	TELO2	6	affinity chromatography technology	St-Denis N (2016)	1
FBXW7	2	PTPRN2	8	genetic interference	Bailey ML (2015)	1
UBQLN4	2	HGS	5	two hybrid	Lim J (2006)	1
HGS	5	STAM2	0	two hybrid, biochemical, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical	Rual JF (2005), Bache KG (2003), Bache KG (2003), Mizuno E (2004), Kanazawa C (2003), Kanazawa C (2003), Stuible M (2010), Havugimana PC (2012), Hoeller D (2006), Wan C (2015)	10
SORT1	1	STAM	3	affinity chromatography technology	Takatsu H (2001)	1
PTPRN2	8	STAM2	0	bioid	St-Denis N (2016)	1
PTPRN2	8	MOSPD2	0	affinity chromatography technology	St-Denis N (2016)	1
HNRNPL	3	PTPRN2	8	affinity chromatography technology	Fei T (2017)	1
PTPRN2	8	CLCC1	4	bioid	St-Denis N (2016)	1
PTPRN	3	HSPA5	0	bioid	St-Denis N (2016)	1
PTPRN	3	MON2	3	affinity chromatography technology	Li X (2016)	1
PTPRN2	8	NUP155	2	bioid	St-Denis N (2016)	1
PTPRN2	8	KRT17	0	bioid	St-Denis N (2016)	1
PTPRN2	8	ANKLE2	5	bioid	St-Denis N (2016)	1
HNRNPL	3	SPTBN4	10	affinity chromatography technology	Fei T (2017)	1
PTPRN2	8	CKAP5	2	two hybrid	Nakayama M (2002)	1
HNRNPL	3	GOLGA4	6	affinity chromatography technology	Fei T (2017)	1
PTPRN	3	PTPRN2	8	affinity chromatography technology	Huttlin EL (2017)	1
HSPA5	0	KRT14	2	two hybrid	Wang J (2011)	1
PTPRN2	8	SNX19	5	bioid	St-Denis N (2016)	1
STAM	3	STAM2	0	imaging technique	Kanazawa C (2003)	1
PTPRN2	8	SEC61A1	1	affinity chromatography technology	St-Denis N (2016)	1
PTPRN2	8	STAM	3	bioid	St-Denis N (2016)	1
UBQLN4	2	STAM2	0	two hybrid	Lim J (2006)	1
HNRNPL	3	CLCC1	4	affinity chromatography technology	Fei T (2017)	1
PTPRN2	8	INTS11	1	affinity chromatography technology	St-Denis N (2016)	1
UBQLN4	2	PTPRN2	8	two hybrid	Lim J (2006)	1
PTPRN2	8	STIM1	1	bioid	St-Denis N (2016)	1
PTPRN2	8	MON2	3	affinity chromatography technology	St-Denis N (2016)	1
STAM	3	HGS	5	two hybrid, affinity chromatography technology, biochemical, pull down, imaging technique, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Asao H (1997), Bache KG (2003), Malik R (2010), Kanazawa C (2003), Kanazawa C (2003), Havugimana PC (2012), Sirisaengtaksin N (2014), Sirisaengtaksin N (2014), Holleman J (2014), Holleman J (2014), Wan C (2015), Berlin I (2010), Huttlin EL (2017)	14
PTPRN	3	SPTBN4	10	two hybrid, affinity chromatography technology	Berghs S (2000), Berghs S (2000)	2
PTPRN2	8	HSPA5	0	bioid	St-Denis N (2016)	1
PTPRN2	8	KRT16	2	bioid	St-Denis N (2016)	1
HSPA5	0	HNRNPL	3	biochemical	Havugimana PC (2012)	1
UBQLN4	2	HSPA5	0	two hybrid, affinity chromatography technology	Matsuda M (2001), Hein MY (2015)	2
PTPRN2	8	SPTBN4	10	two hybrid	Berghs S (2000)	1
PTPRN2	8	SORT1	1	affinity chromatography technology	St-Denis N (2016)	1
UBQLN4	2	PTPRN	3	two hybrid	Lim J (2006)	1
PTPRN2	8	KRT14	2	bioid	St-Denis N (2016)	1
PTPRN	3	SNX19	5	bioid	St-Denis N (2016)	1
PTPRN2	8	HID1	5	bioid	St-Denis N (2016)	1
STAM	3	UBQLN4	2	biochemical	Havugimana PC (2012)	1
PTPRN	3	SEC61A1	1	affinity chromatography technology	Li X (2016)	1
HSPA5	0	SEC61A1	1	unspecified method, affinity chromatography technology	Schaeuble N (2012), Schorr S (2015)	2