PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NCL	1	MDK	0	pull down	Said EA (2002)	1
LGALS3	0	PTPRZ1	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HMGB1	0	PTPRZ1	3	pull down	Milev P (1998)	1
PTN	0	PTPRZ1	3	affinity chromatography technology, imaging technique	Meng K (2000), Koutsioumpa M (2015)	2
TNR	2	PTPRZ1	3	pull down	Milev P (1998)	1
GIT1	10	PTPRZ1	3	affinity chromatography technology	Kawachi H (2001)	1
MDK	0	PTPRZ1	3	pull down	Maeda N (1999)	1
PTPRZ1	3	CNTN1	4	affinity chromatography technology	Garwood J (2003)	1
PTN	0	CTNNB1	30	affinity chromatography technology	Meng K (2000)	1
NCL	1	PTPRZ1	3	affinity chromatography technology	Koutsioumpa M (2013)	1
PTPRZ1	3	CTNNB1	30	affinity chromatography technology	Meng K (2000)	1
VEGFA	3	PTPRZ1	3	affinity chromatography technology, affinity chromatography technology, imaging technique	Koutsioumpa M (2015), Koutsioumpa M (2015), Koutsioumpa M (2015)	3