PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PEX13	0	PEX7	1	pull down, affinity chromatography technology, affinity chromatography technology	Otera H (2002), Huttlin EL (2015), Huttlin EL (2017)	3
TINF2	1	PEX5	2	two hybrid	Lee OH (2011)	1
PEX5	2	ECH1	2	unspecified method, affinity chromatography technology, two hybrid	Ghosh D (2010), Okumoto K (2011), Wang J (2011)	3
PEX5	2	PRDX5	0	unspecified method	Ghosh D (2010)	1
USP2	0	PEX5	2	enzymatic study	Reglinski K (2015)	1
NXF1	0	PEX5	2	affinity chromatography technology	Castello A (2012)	1
PEX5	2	ECI2	2	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
PEX5	2	MLYCD	2	unspecified method	Ghosh D (2010)	1
NXF1	0	USP2	0	affinity chromatography technology	Castello A (2012)	1
CAT	3	HSD17B4	0	biochemical	Havugimana PC (2012)	1
PEX5	2	CAPRIN2	4	two hybrid	Rolland T (2014)	1
PEX5	2	HACL1	2	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
CCDC8	1	AGPS	1	affinity chromatography technology	Hanson D (2014)	1
TYSND1	2	ACOX1	2	enzymatic study	Okumoto K (2011)	1
AGPS	1	GNPAT	2	pull down, affinity chromatography technology	Biermann J (1999), Biermann J (1999)	2
HOXA7	0	PEX5	2	two hybrid	Wang J (2011)	1
PEX5	2	SIRT3	1	two hybrid	Rual JF (2005)	1
PEX5	2	CCDC14	2	two hybrid	Rolland T (2014)	1
PEX5	2	ACOX3	2	unspecified method	Ghosh D (2010)	1
PEX5	2	MPV17	2	unspecified method	Ghosh D (2010)	1
PEX5	2	ACOT4	4	unspecified method	Ghosh D (2010)	1
POT1	2	PIPOX	1	two hybrid	Lee OH (2011)	1
PEX5	2	ACOT8	0	unspecified method, affinity chromatography technology, two hybrid	Ghosh D (2010), Okumoto K (2011), Rolland T (2014)	3
PEX12	2	PEX5	2	two hybrid, two hybrid, pull down, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology	Chang CC (1999), Okumoto K (2000), Okumoto K (2000), Chang CC (1999), Harper CC (2003), Fransen M (2002), Okumoto K (2011)	7
POT1	2	TINF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Liu D (2004), Loayza D (2003), Loayza D (2003), Giannone RJ (2010), Liu D (2004), Liu D (2004), Ye JZ (2004), Lee OH (2011), Lee OH (2011), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	14
IDH1	0	HSD17B4	0	biochemical	Wan C (2015)	1
RANBP6	5	SLC27A2	2	affinity chromatography technology	Huttlin EL (2017)	1
PEX5	2	HAO2	1	unspecified method	Ghosh D (2010)	1
BRCA1	7	XPO1	8	affinity chromatography technology	Ertych N (2016)	1
PEX5	2	FIS1	0	unspecified method	Ghosh D (2010)	1
ATM	9	PEX5	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Watters D (1999), Zhang J (2015), Zhang J (2015)	3
CCDC8	1	USP9X	15	affinity chromatography technology	Hanson D (2014)	1
AGPS	1	SCP2	3	biochemical	Havugimana PC (2012)	1
PEX13	0	PEX5	2	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Gould SJ (1996), Otera H (2002), Otera H (2002), Gould SJ (1996), Okumoto K (2011)	5
BRCA1	7	PEX5	2	two hybrid	Wang J (2011)	1
PEX5	2	PEX2	2	affinity chromatography technology	Okumoto K (2011)	1
CCDC8	1	XPO1	8	affinity chromatography technology	Hanson D (2014)	1
NUDT3	0	PEX5	2	two hybrid	Vinayagam A (2011)	1
PEX5	2	MKRN3	2	two hybrid	Rolland T (2014)	1
MYH9	19	PEX5	2	affinity chromatography technology	Hein MY (2015)	1
PEX5	2	HSDL2	0	affinity chromatography technology	Okumoto K (2011)	1
PEX14	2	PEX2	2	biochemical	Bharti P (2011)	1
NXF1	0	IDH1	0	affinity chromatography technology	Castello A (2012)	1
PEX5	2	NOS2	6	unspecified method	Ghosh D (2010)	1
PEX5	2	AMACR	2	unspecified method	Ghosh D (2010)	1
NXF1	0	XPO1	8	affinity chromatography technology	Bachi A (2000)	1
MOV10	6	NUDT3	0	affinity chromatography technology	Castello A (2012)	1
MOV10	6	CAT	3	affinity chromatography technology	Castello A (2012)	1
HSD17B4	0	FIS1	0	biochemical	Havugimana PC (2012)	1
NXF1	0	SQSTM1	0	affinity chromatography technology	Castello A (2012)	1
XPO1	8	SQSTM1	0	affinity chromatography technology	Kirli K (2015)	1
HSD17B4	0	SCP2	3	biochemical	Havugimana PC (2012)	1
PEX5	2	PECR	2	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
PEX14	2	PEX10	0	biochemical	Bharti P (2011)	1
SCP2	3	ACAA1	2	biochemical	Havugimana PC (2012)	1
SCP2	3	ECI2	2	biochemical	Havugimana PC (2012)	1
RANBP6	5	PEX5	2	biochemical	Kristensen AR (2012)	1
SNUPN	2	XPO1	8	pull down, unspecified method, affinity chromatography technology	Paraskeva E (1999), Xu D (2012), Kirli K (2015)	3
PEX5	2	TM6SF1	1	two hybrid	Rolland T (2014)	1
PEX5	2	CROT	1	unspecified method	Ghosh D (2010)	1
PEX5	2	AGPS	1	affinity chromatography technology	Okumoto K (2011)	1
PEX5	2	EHHADH	1	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
LDHB	4	IDE	3	biochemical	Wan C (2015)	1
ECH1	2	ECI2	2	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Wan C (2015), Floyd BJ (2016), Huttlin EL (2017)	4
PEX5	2	EPHX2	2	unspecified method	Ghosh D (2010)	1
ECH1	2	ZADH2	0	affinity chromatography technology	Huttlin EL (2015)	1
PEX12	2	PEX10	0	two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid	Chang CC (1999), Okumoto K (2000), Okumoto K (2000), Okumoto K (2000), Okumoto K (2000), Chang CC (1999), Fransen M (2002), Fransen M (2002)	8
ACAA1	2	PEX5	2	affinity chromatography technology	Huttlin EL (2015)	1
ATM	9	BRCA1	7	affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Gatei M (2000), Gatei M (2000), Kim ST (1999), Cortez D (1999), Cortez D (1999), Tibbetts RS (2000), Wang Y (2000), Mu JJ (2007), Tsai WB (2008), Gatei M (2000), Gatei M (2000), Gatei M (2000)	12
XPO1	8	ACD	1	affinity chromatography technology	Kirli K (2015)	1
PEX5	2	LONP2	0	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
PEX5	2	S100A6	1	two hybrid	Rolland T (2014)	1
PEX5	2	PAOX	4	unspecified method	Ghosh D (2010)	1
PDZK1	0	DECR2	1	affinity chromatography technology	Huttlin EL (2017)	1
DHRS4	0	EHHADH	1	affinity chromatography technology	Floyd BJ (2016)	1
MOV10	6	MPV17	2	affinity chromatography technology	Castello A (2012)	1
MOV10	6	IDH1	0	affinity chromatography technology	Castello A (2012)	1
LDHB	4	PRDX5	0	biochemical	Wan C (2015)	1
POT1	2	ACD	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Rual JF (2005), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Liu J (2015), Hein MY (2015), Huttlin EL (2017)	12
PEX5	2	HSD17B4	0	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
ACAA1	2	CAT	3	biochemical	Wan C (2015)	1
NEU2	0	PEX14	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRCA1	7	MOV10	6	affinity chromatography technology	Ertych N (2016)	1
PEX5	2	SLC27A2	2	unspecified method	Ghosh D (2010)	1
POT1	2	PEX5	2	two hybrid	Lee OH (2011)	1
PEX5	2	SCP2	3	unspecified method	Ghosh D (2010)	1
PEX5	2	GSTK1	1	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
CAT	3	EHHADH	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Makkar RS (2006), Makkar RS (2006), Makkar RS (2006), Makkar RS (2006)	4
PEX5	2	347918	0	two hybrid	Rolland T (2014)	1
DDO	1	PEX5	2	pull down, unspecified method	Amery L (1998), Ghosh D (2010)	2
PEX5	2	SQSTM1	0	affinity chromatography technology	Zhang J (2015)	1
PEX5	2	ZNF772	1	two hybrid	Rolland T (2014)	1
PEX2	2	PEX10	0	pull down	Okumoto K (2000)	1
PEX14	2	HSD17B4	0	biochemical	Bharti P (2011)	1
CCDC8	1	HSD17B4	0	affinity chromatography technology	Hanson D (2014)	1
PEX5	2	GNPAT	2	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
PEX10	0	PEX5	2	pull down, affinity chromatography technology	Okumoto K (2000), Okumoto K (2011)	2
LDHB	4	CAT	3	biochemical	Wan C (2015)	1
PEX5	2	DHRS4	0	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
IQCN	0	PEX5	2	affinity chromatography technology	Huttlin EL (2017)	1
CCDC8	1	PEX5	2	affinity chromatography technology	Hanson D (2014)	1
PEX13	0	PEX14	2	pull down, pull down, two hybrid, biochemical	Otera H (2002), Otera H (2002), Fransen M (2002), Bharti P (2011)	4
SLC27A2	2	PEX14	2	biochemical	Steinberg SJ (1999)	1
PEX14	2	PEX12	2	biochemical	Bharti P (2011)	1
PEX14	2	DHRS4	0	biochemical	Bharti P (2011)	1
MOV10	6	ZNF772	1	affinity chromatography technology	Castello A (2012)	1
BRCA1	7	RPL14	2	affinity chromatography technology	Ertych N (2016)	1
PEX14	2	GNPAT	2	biochemical	Bharti P (2011)	1
POT1	2	LDHB	4	two hybrid	Lee OH (2011)	1
PEX5	2	IDH1	0	unspecified method	Ghosh D (2010)	1
PEX7	1	PEX5	2	affinity chromatography technology, pull down, two hybrid, pull down, affinity chromatography technology	Dodt G (2001), Dodt G (2001), Dodt G (2001), Otera H (2002), Okumoto K (2011)	5
PEX5	2	IDE	3	unspecified method	Ghosh D (2010)	1
PEX5	2	ZADH2	0	affinity chromatography technology	Okumoto K (2011)	1
DHRS4	0	ECH1	2	affinity chromatography technology	Floyd BJ (2016)	1
PEX14	2	PEX7	1	pull down	Shimizu N (1999)	1
PEX5	2	GDPD5	1	two hybrid	Rolland T (2014)	1
PEX5	2	RPL14	2	two hybrid	Rolland T (2014)	1
ECI2	2	IDE	3	affinity chromatography technology	Floyd BJ (2016)	1
PEX5	2	DECR2	1	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
MYH9	19	AP2M1	5	affinity chromatography technology	Hein MY (2015)	1
ACD	1	PEX5	2	two hybrid	Lee OH (2011)	1
BRCA1	7	MYH9	19	affinity chromatography technology	Ertych N (2016)	1
PEX5	2	PRR13	0	two hybrid	Rolland T (2014)	1
PEX5	2	DAO	2	unspecified method	Ghosh D (2010)	1
XPO1	8	PEX5	2	affinity chromatography technology	Kirli K (2015)	1
XPO1	8	TYSND1	2	affinity chromatography technology	Kirli K (2015)	1
PEX5	2	ACOX1	2	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
PEX5	2	TYSND1	2	affinity chromatography technology	Okumoto K (2011)	1
NEU2	0	PEX5	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
LDHB	4	PEX5	2	two hybrid	Rolland T (2014)	1
SNUPN	2	PEX5	2	two hybrid	Stelzl U (2005)	1
PEX5	2	HAO1	1	unspecified method	Ghosh D (2010)	1
XPO1	8	USP9X	15	affinity chromatography technology	Kirli K (2015)	1
PEX5	2	CRAT	2	unspecified method, affinity chromatography technology	Ghosh D (2010), Okumoto K (2011)	2
USP9X	15	PEX5	2	enzymatic study	Grou CP (2012)	1
BRCA1	7	USP2	0	two hybrid, two hybrid	Woods NT (2012), Hayes SD (2012)	2
CCDC8	1	CAT	3	affinity chromatography technology	Hanson D (2014)	1
PEX14	2	AGPS	1	biochemical	Bharti P (2011)	1
MOV10	6	PEX5	2	affinity chromatography technology	Castello A (2012)	1
PEX14	2	PEX5	2	two hybrid, pull down, pull down, pull down, pull down, two hybrid, two hybrid, pull down, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, biochemical	Okumoto K (2000), Okumoto K (2000), Otera H (2002), Otera H (2002), Shimizu N (1999), Fransen M (2002), Fransen M (2002), Fransen M (2002), Will GK (1999), Will GK (1999), Will GK (1999), Okumoto K (2011), Bharti P (2011), Bharti P (2011)	14
XPO1	8	AP2M1	5	affinity chromatography technology	Kirli K (2015)	1
ACOX1	2	CAT	3	biochemical	Wan C (2015)	1
PDZK1	0	PEX5	2	two hybrid	Rual JF (2005)	1
PEX5	2	HMGCL	2	unspecified method	Ghosh D (2010)	1
NXF1	0	NUDT3	0	affinity chromatography technology	Castello A (2012)	1
MKRN3	2	PEX10	0	two hybrid	Woodsmith J (2012)	1
PEX5	2	BAAT	1	unspecified method	Ghosh D (2010)	1
PEX5	2	ACOT2	0	unspecified method	Ghosh D (2010)	1
CAT	3	PEX5	2	two hybrid, unspecified method, affinity chromatography technology	Watters D (1999), Ghosh D (2010), Okumoto K (2011)	3
CAT	3	PRDX5	0	biochemical	Wan C (2015)	1
PEX5	2	AGXT	0	unspecified method	Ghosh D (2010)	1
PEX5	2	NUDT19	2	unspecified method	Ghosh D (2010)	1
PEX5	2	ACAD11	0	affinity chromatography technology	Okumoto K (2011)	1
BRCA1	7	LDHB	4	affinity chromatography technology	Ertych N (2016)	1
PEX5	2	PIPOX	1	unspecified method	Ghosh D (2010)	1
PDZK1	0	ECI2	2	affinity chromatography technology	Huttlin EL (2017)	1
AP2M1	5	PEX14	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MOV10	6	SQSTM1	0	affinity chromatography technology	Castello A (2012)	1
PEX5	2	TOMM7	0	two hybrid	Rolland T (2014)	1
XPO1	8	GNPAT	2	affinity chromatography technology	Kirli K (2015)	1
TINF2	1	ACD	1	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Ye JZ (2004), Ye JZ (2004), Ye JZ (2004), Liu D (2004), Liu D (2004), Liu D (2004), Lee OH (2011), Lee OH (2011), Rolland T (2014), Hein MY (2015), Huttlin EL (2017)	11
AP2M1	5	PEX5	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCDC8	1	RPL14	2	affinity chromatography technology	Hanson D (2014)	1
MOV10	6	USP2	0	affinity chromatography technology	Castello A (2012)	1
PEX5	2	NUDT7	0	unspecified method	Ghosh D (2010)	1
ACAA1	2	PEX7	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PEX5	2	ACOX2	5	unspecified method	Ghosh D (2010)	1
HSD17B4	0	ACAA1	2	biochemical	Havugimana PC (2012)	1