PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
NOD1	3	NOD2	1	affinity chromatography technology, affinity chromatography technology	Travassos LH (2010), Travassos LH (2010)	2
CASP1	1	NOD2	1	affinity chromatography technology	Damiano JS (2004)	1
CASP8	1	FADD	1	biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Gajate C (2005), Micheau O (2003), Srinivasula SM (1997), Srinivasula SM (1997), Henshall DC (2003), Boldin MP (1996), Oshima S (2009), Thomas LR (2002), Ikner A (2011), Tenev T (2011), Ramakrishnan P (2011), Mahul-Mellier AL (2011), Won M (2010), Ryu SW (2003), Sinha SK (2004), Biton S (2011), Fu K (2012), Fu K (2012), Gonzalvez F (2012), Lee EW (2012), Rebe C (2007), Feoktistova M (2012), Wang J (2011), Puliyappadamba VT (2013), Choi H (2011), Feoktistova M (2011), Selmi T (2015), Yamaguchi N (2015), Saitoh Y (2016), Moquin DM (2013), Ranjan K (2016), Nakazawa S (2016), Jeong M (2017), Jeong M (2017), Pescatore A (2016)	35
NLRC4	2	NLRP1	5	affinity chromatography technology	Damiano JS (2001)	1
NLRC4	2	XK	0	affinity chromatography technology	Damiano JS (2004)	1
NOD1	3	CASP1	1	affinity chromatography technology	Inohara N (1999)	1
NLRC4	2	NOD1	3	affinity chromatography technology	Damiano JS (2004)	1
NOD1	3	CASP8	1	affinity chromatography technology	Inohara N (1999)	1
NLRC4	2	NLRP3	2	affinity chromatography technology	Damiano JS (2004)	1
ALB	1	NLRC4	2	affinity chromatography technology	Zhou M (2004)	1
CASP8	1	CASP1	1	enzymatic study	Srinivasula SM (1996)	1
NLRC4	2	PYCARD	1	two hybrid	Geddes BJ (2001)	1
FADD	1	NLRC4	2	affinity chromatography technology	Raghawan AK (2017)	1
CASP1	1	NLRC4	2	affinity chromatography technology, affinity chromatography technology	Damiano JS (2004), Damiano JS (2001)	2
NLRC4	2	BCL10	0	affinity chromatography technology	Damiano JS (2001)	1
PYCARD	1	CASP1	1	affinity chromatography technology, imaging technique	Dutta D (2015), Dutta D (2015)	2
NLRC4	2	NOD2	1	affinity chromatography technology, affinity chromatography technology	Damiano JS (2004), Damiano JS (2001)	2
NLRC4	2	NLRC4	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Damiano JS (2004), Damiano JS (2001), Kumar Y (2010)	3
PSMC5	4	NLRC4	2	affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology	Kumar Y (2010), Kumar Y (2010), Kumar Y (2010), Kumar Y (2010), Raghawan AK (2017)	5
CASP8	1	NLRC4	2	affinity chromatography technology, affinity chromatography technology	Kumar Y (2010), Raghawan AK (2017)	2
NLRC4	2	NAIP	0	affinity chromatography technology	Damiano JS (2004)	1
CASP1	1	XK	0	affinity chromatography technology	Damiano JS (2004)	1