PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TJP1	2	JAM3	0	pull down	Ebnet K (2003)	1
CSNK1A1L	1	JAM2	0	two hybrid	Wang J (2011)	1
TJP1	2	JAM2	0	pull down	Ebnet K (2003)	1
JAM2	0	JAM3	0	pull down, pull down	Ramani SR (2012), Ramani SR (2012)	2
JAM2	0	NME3	0	two hybrid	Wang J (2011)	1
GPR20	2	JAM2	0	two hybrid	Wang J (2011)	1
JAM2	0	YBX1	1	two hybrid	Wang J (2011)	1
PARD3	5	TJP1	2	imaging technique	Suzuki A (2001)	1
JAM2	0	SOX8	4	two hybrid	Wang J (2011)	1
PARD3	5	JAM3	0	pull down, affinity chromatography technology	Ebnet K (2003), Ebnet K (2003)	2
PARD3	5	JAM2	0	pull down, affinity chromatography technology	Ebnet K (2003), Ebnet K (2003)	2
JAM2	0	TDP2	2	two hybrid	Wang J (2011)	1
JAM2	0	JAM2	0	pull down	Ramani SR (2012)	1