PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
PZP	3	TGFB2	2	pull down	Philip A (1994)	1
TMEM248	0	PZP	3	affinity chromatography technology	Hein MY (2015)	1
MMP2	2	A2M	8	pull down, imaging technique	Arbelaez LF (1997), Chen TC (2014)	2
CFTR	5	A2M	8	affinity chromatography technology, affinity chromatography technology	Wang X (2006), Pankow S (2015)	2
MMP2	2	TGFB1	2	enzymatic study, imaging technique	Yu Q (2000), Chen TC (2014)	2
TUBGCP4	3	PZP	3	affinity chromatography technology	Hein MY (2015)	1
PZP	3	TGFB1	2	pull down	Philip A (1994)	1
CFTR	5	PZP	3	affinity chromatography technology	Pankow S (2015)	1
DEFA6	0	PZP	3	affinity chromatography technology	Huttlin EL (2017)	1
MMP2	2	PZP	3	pull down	Arbelaez LF (1997)	1
A2M	8	PZP	3	affinity chromatography technology	Huttlin EL (2017)	1