PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MAP4K2	1	MCM3AP-AS1	0	two hybrid	Vinayagam A (2011)	1
MAP4K2	1	MAP3K1	4	pull down, affinity chromatography technology, affinity chromatography technology	Yuasa T (1998), Chadee DN (2002), Chadee DN (2002)	3
RAB8A	0	MAP4K2	1	two hybrid, affinity chromatography technology, biochemical	Ren M (1996), Ren M (1996), Ren M (1996)	3
MAP4K2	1	SERPINA4	0	two hybrid	Vinayagam A (2011)	1
MAP4K2	1	DEFB1	0	two hybrid	Vinayagam A (2011)	1
MAP4K2	1	MAP3K11	7	affinity chromatography technology	Chadee DN (2002)	1
TRAF2	1	MAP3K1	4	biochemical, affinity chromatography technology, affinity chromatography technology, enzymatic study, imaging technique	Baud V (1999), Baud V (1999), Wu Y (2006), Charlaftis N (2014), Chen TC (2014)	5
MAP4K2	1	XRCC6	3	two hybrid	Vinayagam A (2011)	1
MAP4K2	1	SNRNP35	1	two hybrid	Vinayagam A (2011)	1
MAP3K11	7	MAP2K4	3	enzymatic study	Merritt SE (1999)	1
MAP3K11	7	HSP90AA1	7	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang H (2004), Zhang H (2004), Blessing NA (2014)	3
MAP4K2	1	TRAF2	1	pull down, affinity chromatography technology	Yuasa T (1998), Yuasa T (1998)	2
MAP4K2	1	MAP2K4	3	pull down	Yuasa T (1998)	1
HSP90AA1	7	MAP4K2	1	affinity chromatography technology	Taipale M (2012)	1
POT1	2	MAP4K2	1	two hybrid	Lee OH (2011)	1
MAP4K2	1	HNRNPA2B1	2	two hybrid	Vinayagam A (2011)	1
MAP3K1	4	MAP2K4	3	affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study	Cheng J (2000), Gallagher ED (2004), Ryoo K (2004), Ryoo K (2004), Tu Z (2003), Takekawa M (2005), Xia Y (1998), Xia Y (1998), Gallagher ED (2002), Xia Y (1998), Chen Z (2006), Ahn JS (2016)	12
MAP4K2	1	NACAD	4	two hybrid	Vinayagam A (2011)	1
XRCC6	3	POT1	2	affinity chromatography technology	Hein MY (2015)	1
TRAF2	1	MAP3K11	7	affinity chromatography technology	Korchnak AC (2009)	1
MAP4K2	1	PRDX4	0	two hybrid	Vinayagam A (2011)	1