PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
ADRB2	0	EEF1A1	0	affinity chromatography technology	Roy SJ (2013)	1
RAB27A	0	GDF9	2	two hybrid	Stelzl U (2005)	1
RAB27A	0	SYTL3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Fukuda M (2003), Kuroda TS (2002), Kuroda TS (2002), Kuroda TS (2002)	4
RAB27A	0	ZBTB16	4	two hybrid	Stelzl U (2005)	1
MLPH	1	MYO5A	17	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology	Passeron T (2004), Fukuda M (2004), Fukuda M (2004), Nagashima K (2002), Nagashima K (2002)	5
EXPH5	4	RAB27A	0	affinity chromatography technology, affinity chromatography technology	Kuroda TS (2002), Kuroda TS (2002)	2
FBXO6	0	COPS6	0	affinity chromatography technology, affinity chromatography technology	Liu B (2012), Huttlin EL (2015)	2
UNC13B	8	RAB27A	0	affinity chromatography technology	Boggio E (2013)	1
ZBTB16	4	EEF1A1	0	two hybrid, pull down, affinity chromatography technology	Rho SB (2006), Rho SB (2006), Rho SB (2006)	3
MLPH	1	RAB27A	0	affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Passeron T (2004), Nagashima K (2002), Nagashima K (2002), Strom M (2002), Strom M (2002), Kuroda TS (2002), Kuroda TS (2002)	7
RAB27A	0	LRIF1	3	two hybrid	Stelzl U (2005)	1
RAB27A	0	APP	1	pull down	Olah J (2011)	1
RAB27A	0	ERG28	0	two hybrid	Stelzl U (2005)	1
RAB27A	0	EEF1A1	0	two hybrid	Stelzl U (2005)	1
RAB27A	0	COPS6	0	two hybrid	Stelzl U (2005)	1
RAB27A	0	SYTL5	2	affinity chromatography technology, pull down, affinity chromatography technology	Fukuda M (2003), Kuroda TS (2002), Kuroda TS (2002)	3
RPH3AL	1	UNC13B	8	pull down	Cheviet S (2004)	1
RAB27A	0	SYTL2	1	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Fukuda M (2003), Strom M (2002), Kuroda TS (2002), Kuroda TS (2002), Kuroda TS (2002)	5
RAB27A	0	RPH3AL	1	pull down	Cheviet S (2004)	1
ADRB2	0	RAB27A	0	protein complementation assay	Kittanakom S (2014)	1
UNC13D	2	RAB27A	0	pull down	Shirakawa R (2004)	1
RPH3A	7	RAB27A	0	affinity chromatography technology	Huttlin EL (2017)	1
MYO5A	17	RAB27A	0	pull down, affinity chromatography technology	Wu X (2002), Nagashima K (2002)	2
RAB27A	0	RBM48	1	two hybrid	Stelzl U (2005)	1
RAB27A	0	MYRIP	3	affinity chromatography technology	Fukuda M (2003)	1
FBXO6	0	RAB27A	0	affinity chromatography technology	Liu B (2012)	1
FBXO6	0	EEF1A1	0	affinity chromatography technology	Liu B (2012)	1
RAB27A	0	SYTL1	1	affinity chromatography technology, two hybrid, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Fukuda M (2003), Strom M (2002), Strom M (2002), Strom M (2002), Strom M (2002), Kuroda TS (2002), Kuroda TS (2002), Kuroda TS (2002)	8
RAB27A	0	SYTL4	0	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Yi Z (2002), Fukuda M (2003), Fukuda M (2003), Fukuda M (2002), Fukuda M (2002), Torii S (2002), Kuroda TS (2002), Kuroda TS (2002), Yi Z (2002), van Breevoort D (2014)	10
RAB27A	0	CEP126	0	two hybrid	Stelzl U (2005)	1