PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
RARA	5	SUZ12	0	affinity chromatography technology	Villa R (2007)	1
AJUBA	2	RARA	5	affinity chromatography technology, affinity chromatography technology, pull down, biochemical	Hou Z (2010), Hou Z (2010), Hou Z (2010), Hou Z (2010)	4
ZNF576	2	AJUBA	2	affinity chromatography technology	Huttlin EL (2017)	1
ARID1A	16	RARA	5	pull down	Flajollet S (2007)	1
RXRA	1	NCOA1	6	pull down, pull down, two hybrid, far western blotting, pull down, pull down, two hybrid, pull down, pull down, pull down, pull down, two hybrid, pull down	Jeyakumar M (1997), Yang W (2000), Shao G (2000), Shao G (2000), Mouchon A (1999), Herdick M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Monden T (1999), Kurtev V (2004), Osburn DL (2001), DiRenzo J (1997)	13
RARG	2	NCOR1	9	two hybrid, pull down	Dowell P (1999), Dowell P (1999)	2
RARG	2	SUZ12	0	affinity chromatography technology	Amat R (2011)	1
NCOA3	3	PSMC5	4	affinity chromatography technology, imaging technique	Ferry C (2009), Ferry C (2009)	2
RARG	2	NR2F6	1	two hybrid	Avram D (1999)	1
HACE1	2	RARA	5	affinity chromatography technology	Zhao J (2009)	1
NCOR1	9	NCOA3	3	pull down, affinity chromatography technology, affinity chromatography technology, pull down	Li X (2002), Li X (2002), Li X (2002), Li X (2002)	4
RARA	5	PSMC5	4	pull down, pull down, affinity chromatography technology, two hybrid	Zechel C (2002), vom Baur E (1996), Ferry C (2009), Choi HS (1996)	4
ARID1A	16	RARG	2	pull down	Flajollet S (2007)	1
RARG	2	KCNJ6	6	affinity chromatography technology	Huttlin EL (2017)	1
RARG	2	ZNF576	2	two hybrid	Wang J (2011)	1
RARG	2	ITGB1BP2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Albers M (2005), Taipale M (2014), Taipale M (2014)	3
ARID1A	16	SMARCD3	0	biochemical, biochemical	Havugimana PC (2012), Wan C (2015)	2
MRPL12	0	RARG	2	two hybrid	Wang J (2011)	1
YAP1	0	RARG	2	affinity chromatography technology, affinity chromatography technology	Guo PD (2016), Guo PD (2016)	2
AJUBA	2	RARG	2	affinity chromatography technology	Hou Z (2010)	1
RARG	2	PNRC1	0	two hybrid	Albers M (2005)	1
RARG	2	NR0B2	1	two hybrid	Albers M (2005)	1
RXRG	1	RXRA	1	affinity chromatography technology	Huttlin EL (2017)	1
RXRA	1	PSMC5	4	pull down, two hybrid	vom Baur E (1996), Choi HS (1996)	2
YAP1	0	AJUBA	2	affinity chromatography technology	Enzo E (2015)	1
RARG	2	NCOA1	6	two hybrid, pull down	Albers M (2005), Flajollet S (2007)	2
HACE1	2	RARG	2	affinity chromatography technology, affinity chromatography technology	Zhao J (2009), Zhao J (2009)	2
RXRG	1	NR2F6	1	affinity chromatography technology	Huttlin EL (2017)	1
NCOA3	3	RARG	2	two hybrid	Albers M (2005)	1
RARA	5	ITGB1BP2	0	two hybrid, affinity chromatography technology, affinity chromatography technology	Albers M (2005), Taipale M (2014), Taipale M (2014)	3
NCOA1	6	NCOA3	3	affinity chromatography technology, affinity chromatography technology	Lodrini M (2008), Lodrini M (2008)	2
NKX3-1	2	RARG	2	two hybrid	Wang X (2008)	1
RARA	5	RXRG	1	two hybrid, two hybrid, two hybrid, two hybrid, two hybrid	Rual JF (2005), Albers M (2005), Wang J (2011), Rolland T (2014), Yu H (2011)	5
RARG	2	RARA	5	affinity chromatography technology	Huttlin EL (2017)	1
RARG	2	MAP6	3	two hybrid	Albers M (2005)	1
RARG	2	SPHK1	0	two hybrid	Wang J (2011)	1
NR0B2	1	RXRA	1	two hybrid, pull down, two hybrid	Lee YK (2000), Brendel C (2002), Wang J (2011)	3
RARG	2	ZPLD1	0	affinity chromatography technology	Huttlin EL (2017)	1
NCOR2	12	RXRA	1	two hybrid, pull down, two hybrid, two hybrid	Tagami T (1998), Mouchon A (1999), Li H (1997), Albers M (2005)	4
SMARCD3	0	RXRA	1	pull down	Flajollet S (2007)	1
NCOA3	3	NR0B2	1	two hybrid	Lee YK (2002)	1
SMARCD3	0	RARG	2	pull down	Flajollet S (2007)	1
RARG	2	RXRB	0	two hybrid, affinity chromatography technology	Albers M (2005), Huttlin EL (2017)	2
RARG	2	PNMA8A	2	affinity chromatography technology	Huttlin EL (2017)	1
ARID1A	16	NCOA1	6	pull down	Flajollet S (2007)	1
RARA	5	NCOA3	3	pull down, pull down, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Torchia J (1997), Reineke EL (2007), Reineke EL (2007), Albers M (2005), Takeshita A (1997), Ferry C (2009), Gianni M (2006), Li CW (2010)	8
RARG	2	PSMC5	4	two hybrid	Albers M (2005)	1
NCOA3	3	RXRA	1	pull down, pull down, imaging technique, pull down, pull down	Chen H (1997), Lee WY (2002), Sinkkonen L (2005), Yang W (2000), Takeshita A (1997)	5
RARG	2	RXRA	1	two hybrid	Albers M (2005)	1
ACY3	1	RARG	2	two hybrid	Wang J (2011)	1
RARA	5	NCOA1	6	pull down, pull down, fluorescent resonance energy transfe, pull down, pull down, affinity chromatography technology, two hybrid, pull down, pull down, pull down, pull down	Llopis J (2000), Llopis J (2000), Llopis J (2000), Mouchon A (1999), Torchia J (1997), Reineke EL (2007), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Cai SY (2010), DiRenzo J (1997)	11
MTMR6	2	RARG	2	two hybrid	Wang J (2011)	1
TNIP1	1	RARA	5	two hybrid	Gurevich I (2009)	1
NCOR1	9	RXRA	1	pull down, pull down, pull down	Sun Y (2004), Herdick M (2000), Krogsdam AM (2002)	3
RARA	5	RXRB	0	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Albers M (2005), Wang J (2011), Huttlin EL (2017)	4
LSR	0	RARG	2	two hybrid	Wang J (2011)	1
NR2F6	1	NCOA1	6	pull down	Zhu XG (2000)	1
OIP5	1	RARG	2	two hybrid	Wang J (2011)	1
RARG	2	RHPN2	3	two hybrid	Wang J (2011)	1
RXRA	1	NR2F6	1	two hybrid	Avram D (1999)	1
RARG	2	H2AFZ	1	affinity chromatography technology	Amat R (2011)	1
YAP1	0	PSMC5	4	affinity chromatography technology	Enzo E (2015)	1
RARG	2	RBL2	5	affinity chromatography technology	Huttlin EL (2017)	1
NCOR1	9	NCOA1	6	pull down	Stevens A (2003)	1
SMARCD3	0	RARA	5	pull down, pull down	Flajollet S (2007), Flajollet S (2007)	2
IL24	0	RARG	2	two hybrid	Wang J (2011)	1
NCOR2	12	NCOA3	3	affinity chromatography technology, pull down, pull down	Karmakar S (2010), Karmakar S (2010), Karmakar S (2010)	3
RXRB	0	NCOA1	6	two hybrid	Albers M (2005)	1
NR0B2	1	RARA	5	pull down, two hybrid, pull down	Seol W (1996), Seol W (1998), Seol W (1998)	3
NCOR2	12	RXRG	1	two hybrid	Albers M (2005)	1
YAP1	0	ARID1A	16	bioid, affinity chromatography technology	Couzens AL (2013), Enzo E (2015)	2
TNIP1	1	RARG	2	two hybrid	Gurevich I (2009)	1
AJUBA	2	RXRG	1	affinity chromatography technology	Hou Z (2010)	1
NCOR2	12	RARA	5	affinity chromatography technology, pull down, pull down, far western blotting, two hybrid, pull down, two hybrid, pull down, pull down	Dong S (2002), Hong SH (1997), Mouchon A (1999), Li H (1997), Li H (1997), Reineke EL (2007), Albers M (2005), Dhordain P (1997), Johnson DR (2006)	9
RARG	2	PNRC2	0	two hybrid	Albers M (2005)	1
NCOR2	12	NCOR1	9	biochemical, two hybrid	Li J (2000), Korutla L (2005)	2
NCOR2	12	RARG	2	two hybrid	Albers M (2005)	1
NR0B2	1	RXRG	1	pull down	Seol W (1996)	1
RXRA	1	RARA	5	pull down, biochemical, affinity chromatography technology, x-ray crystallography, far western blotting, two hybrid, imaging technique, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, pull down, two hybrid, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology	Benkoussa M (2002), Bugge TH (1992), Wu Q (2004), Pogenberg V (2005), Li H (1997), Albers M (2005), Bellodi C (2006), Garcia-Fernandez LF (1998), Wang J (2011), Rochel N (2011), Rochel N (2011), Perlmann T (1995), Perlmann T (1995), DiRenzo J (1997), Martin PJ (2003), Martin PJ (2003), Chen TC (2014), Fujiu K (2005), Fujiu K (2005)	19
RARA	5	NCOR1	9	two hybrid, pull down, pull down, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, affinity chromatography technology, far western blotting, affinity chromatography technology, two hybrid, pull down, pull down, pull down	Dowell P (1999), Dowell P (1999), Guidez F (1998), Guidez F (1998), Li CW (2009), Loinder K (2004), Loinder K (2004), Minucci S (2000), Grignani F (1998), Grignani F (1998), DiRenzo J (1997), Zhu P (2006), Wang J (2011), Hoerlein AJ (1995), DiRenzo J (1997), DiRenzo J (1997)	16
RARG	2	RXRG	1	two hybrid	Albers M (2005)	1