PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EGFR	5	RASA1	3	pull down, unspecified method, pull down	Daly RJ (1996), Jones RB (2006), Marengere LE (1992)	3
RASA1	3	DOK2	2	affinity chromatography technology, affinity chromatography technology	Dunant NM (2000), Di Cristofano A (1998)	2
DOK1	2	SRC	2	pull down, unspecified method	van Dijk TB (2000), Liu BA (2012)	2
HCK	5	ERBB3	3	unspecified method	Jones RB (2006)	1
HNRNPL	3	APP	1	affinity chromatography technology	Fei T (2017)	1
CD5	1	RASA1	3	affinity chromatography technology	Dennehy KM (1998)	1
CSK	3	RASA1	3	pull down	Neet K (1995)	1
HNRNPL	3	IGF1R	5	affinity chromatography technology	Fei T (2017)	1
NTRK1	1	PDGFRB	8	affinity chromatography technology	Emdal KB (2015)	1
CSK	3	IGF1R	5	two hybrid, affinity chromatography technology	Arbet-Engels C (1999), Arbet-Engels C (1999)	2
GRB2	2	KHDRBS1	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, two hybrid, unspecified method, affinity chromatography technology, two hybrid	Liu SK (1998), Oneyama C (2002), Shen Z (1999), Shen Z (1999), Bandyopadhyay S (2010), Asbach B (2012), Bisson N (2011), Wang J (2011)	8
ERBB2	6	DOK1	2	unspecified method	Jones RB (2006)	1
KHDRBS1	1	HCK	5	unspecified method, affinity chromatography technology, fluorescent resonance energy transfe	Asbach B (2012), Asbach B (2012), Asbach B (2012)	3
EGFR	5	CAV2	0	affinity chromatography technology, two hybrid, protein complementation assay, pull down	Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Abulrob A (2004)	4
PXN	1	PTK2B	6	affinity chromatography technology, far western blotting, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hiregowdara D (1997), Hiregowdara D (1997), Matsuya M (1998), Matsuya M (1998), Anfosso F (2001), Ivankovic-Dikic I (2000)	6
SRC	2	RACK1	2	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chang BY (1998), Chang BY (1998), Chang BY (1998), Chang BY (1998), Chen S (2008)	5
SRC	2	PDGFRB	8	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lee CW (2007), Collin G (2007), Wu CY (2008)	3
SLC9A2	1	SRC	2	pull down	Chow CW (1999)	1
ERBB2	6	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology	Scaltriti M (2009), Graus-Porta D (1997), Le XF (2005), Chen TC (2014), Ritch PS (2005)	5
NTRK1	1	MAP4K4	13	affinity chromatography technology	Emdal KB (2015)	1
CAV2	0	NCK1	0	pull down	Lee H (2002)	1
RASA1	3	OLIG1	0	two hybrid	Grossmann A (2015)	1
EGFR	5	YES1	1	affinity chromatography technology	Tong J (2014)	1
ABL1	9	PLCG1	6	pull down	Koch A (2000)	1
DNAJA3	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Chen CY (2013), Foerster S (2013), Tong J (2014)	3
SPSB1	3	RASA1	3	affinity chromatography technology	Wang D (2005)	1
ZAP70	5	CD5	1	affinity chromatography technology	Gary-Gouy H (1997)	1
ERBB4	5	GRB2	2	affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Kiuchi T (2014)	2
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
NTRK1	1	G3BP1	4	affinity chromatography technology	Emdal KB (2015)	1
DOK1	2	PLCG1	6	pull down	van Dijk TB (2000)	1
ABL1	9	DOK2	2	enzymatic study	Di Cristofano A (1998)	1
EGFR	5	G3BP1	4	affinity chromatography technology	Yao Z (2017)	1
DOK2	2	LCK	0	two hybrid	Grossmann A (2015)	1
GRB2	2	OLIG1	0	two hybrid	Grossmann A (2015)	1
EIF1	0	APP	1	pull down	Olah J (2011)	1
ZAP70	5	APP	1	pull down	Olah J (2011)	1
INSR	9	KHDRBS1	1	affinity chromatography technology	Sanchez-Margalet V (2001)	1
NTRK1	1	ARHGAP35	12	affinity chromatography technology	Emdal KB (2015)	1
NFKBIA	0	SRC	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
DOK1	2	YES1	1	pull down	van Dijk TB (2000)	1
NTRK1	1	HNRNPL	3	affinity chromatography technology	Emdal KB (2015)	1
ERBB3	3	PTK2B	6	affinity chromatography technology	Verma N (2017)	1
EGFR	5	DOK1	2	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
NTRK1	1	RASA1	3	affinity chromatography technology	Emdal KB (2015)	1
HNRNPL	3	SRC	2	affinity chromatography technology	Fei T (2017)	1
HNRNPL	3	SPSB1	3	affinity chromatography technology	Fei T (2017)	1
SRC	2	KHDRBS1	1	two hybrid, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study	Stelzl U (2005), Oneyama C (2002), Koch CA (1992), Shen Z (1999), Shen Z (1999), Finan PM (1996), Asbach B (2012), Asbach B (2012), Asbach B (2012), Kaabeche K (2004), Pincheira R (2008), Wong G (1992), Williger BT (1997), Wong BR (1999)	14
NTRK1	1	PLCG1	6	pull down, two hybrid, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Ohmichi M (1991), Qian X (1998), Meakin SO (1999), Koch A (2000), Emdal KB (2015), Emdal KB (2015)	6
PTK2B	6	GRB2	2	affinity chromatography technology, affinity chromatography technology	Blaukat A (1999), Bruzzaniti A (2009)	2
EGFR	5	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Blagoev B (2003), Oneyama C (2002), Wong L (1999), Okutani T (1994), Okutani T (1994), Okutani T (1994), Tortora G (1997), Daly RJ (1996), Buday L (1994), Lowenstein EJ (1992), Lowenstein EJ (1992), Braverman LE (1999), Khan EM (2008), Bonaccorsi L (2007), Miraoui H (2010), Tong J (2009), Severe N (2011), Takahashi Y (1999), Tarcic G (2009), Thien CB (1997), Burke P (2001), Katayama H (1999), Meisner H (1995), Kurada BR (2009), Tong J (2008), Bisson N (2011), Fukazawa T (1996), Fukazawa T (1996), Jones RB (2006), Sigismund S (2013), Sigismund S (2013), Foerster S (2013), Bisson N (2011), Gotoh N (1994), Wu SL (2006), Wu SL (2006), Tong J (2014), Oksvold MP (2001), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Song F (2016), Song F (2016), Ueno H (1995), Ueno H (1995), Ueno H (1995), Prigent SA (1996), Kapoor GS (2010), Kapoor GS (2010), Okamura T (2009)	51
HRAS	2	INSR	9	enzymatic study	OBrien RM (1987)	1
PTK2B	6	RASA1	3	affinity chromatography technology, pull down, affinity chromatography technology	Chow A (2000), Chow A (2000), Zrihan-Licht S (2000)	3
RACK1	2	PLCG1	6	far western blotting	Disatnik MH (1994)	1
FGFR1	2	SRC	2	affinity chromatography technology, affinity chromatography technology	Dudka AA (2010), Vecchione A (2007)	2
PLCG1	6	ERBB2	6	affinity chromatography technology, biochemical, unspecified method	Peles E (1991), Arteaga CL (1991), Jones RB (2006)	3
RASA1	3	EIF1	0	two hybrid	Vinayagam A (2011)	1
ABL1	9	HCK	5	affinity chromatography technology	Warmuth M (1997)	1
PLCG1	6	RASA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Jabado N (1998), Jabado N (1997), Jabado N (1997)	3
CSK	3	G3BP1	4	affinity chromatography technology, affinity chromatography technology	Rahmouni S (2005), Rahmouni S (2005)	2
BTRC	1	EZH2	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sahasrabuddhe AA (2014), Sahasrabuddhe AA (2014), Huttlin EL (2017)	3
RASA1	3	ABL1	9	affinity chromatography technology	Druker B (1992)	1
NTRK1	1	KHDRBS1	1	affinity chromatography technology	Emdal KB (2015)	1
GRB2	2	SOCS1	1	pull down	De Sepulveda P (1999)	1
DOK2	2	PLCG1	6	affinity chromatography technology	Huttlin EL (2017)	1
RASA1	3	PXN	1	affinity chromatography technology	Shikata Y (1999)	1
KDR	4	RASA1	3	affinity chromatography technology	DAngelo G (1999)	1
RASA1	3	NCK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, far western blotting, far western blotting, pull down, affinity chromatography technology	Holland SJ (1997), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011), Ger M (2011)	7
SRC	2	PTK2B	6	affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology	Keely SJ (2000), Kumar S (1999), Dikic I (1996), Dikic I (1996), Bruzzaniti A (2009)	5
EZH2	4	RACK1	2	affinity chromatography technology	Cao Q (2014)	1
KHDRBS1	1	YES1	1	unspecified method, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study	Asbach B (2012), Asbach B (2012), Asbach B (2012), Kaabeche K (2004)	4
HRAS	2	BTRC	1	pull down, affinity chromatography technology, affinity chromatography technology	Kim SE (2009), Kim SE (2009), Kim SE (2009)	3
HNRNPL	3	EGFR	5	affinity chromatography technology	Fei T (2017)	1
SLC9A2	1	RASA1	3	pull down	Chow CW (1999)	1
HTT	14	EGFR	5	affinity chromatography technology	Liu YF (1997)	1
FGFR1	2	YES1	1	affinity chromatography technology, affinity chromatography technology, pull down	Zhang P (2006), Zhang P (2006), Zhang P (2006)	3
FGFR1	2	ERBB3	3	unspecified method	Jones RB (2006)	1
EGFR	5	IGF1R	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Morgillo F (2006), Riedemann J (2007), Riedemann J (2007)	3
RASA1	3	HTT	14	pull down, affinity chromatography technology	Liu YF (1997), Liu YF (1997)	2
LCK	0	SOCS1	1	affinity chromatography technology, affinity chromatography technology	Venkitachalam S (2011), Venkitachalam S (2011)	2
EGFR	5	PTK2B	6	affinity chromatography technology, affinity chromatography technology	Keely SJ (2000), Ivankovic-Dikic I (2000)	2
SOCS1	1	ERBB2	6	unspecified method	Jones RB (2006)	1
RASA1	3	ANXA6	4	far western blotting, pull down	Chow A (1999), Chow A (1999)	2
RASA1	3	ZNF579	2	two hybrid	Vinayagam A (2011)	1
ZAP70	5	ABL1	9	affinity chromatography technology	Neumeister EN (1995)	1
APP	1	SRC	2	affinity chromatography technology	Austin SA (2009)	1
RASA1	3	BTRC	1	genetic interference	Spiegelman VS (2002)	1
RASA1	3	HRAS	2	pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology	Molloy DP (1995), Scheffzek K (1997), Giglione C (2001), Ji H (2016), Ji H (2016), Ji H (2016)	6
HNRNPL	3	RASA1	3	affinity chromatography technology	Fei T (2017)	1
NTRK1	1	IGF1R	5	affinity chromatography technology	Emdal KB (2015)	1
PXN	1	NCK1	0	pull down	Turner CE (1999)	1
NCK1	0	GRB2	2	affinity chromatography technology, affinity chromatography technology	de Castro RO (2012), de Castro RO (2012)	2
LCK	0	PTK2B	6	affinity chromatography technology	Ganju RK (1997)	1
EGFR	5	TRMT2A	4	affinity chromatography technology	Tong J (2014)	1
MAP4K4	13	RASA1	3	affinity chromatography technology	Becker E (2000)	1
IGF1R	5	APP	1	pull down	Olah J (2011)	1
RASA1	3	EZH2	4	two hybrid	Vinayagam A (2011)	1
EGFR	5	CSK	3	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
INSR	9	GRB2	2	affinity chromatography technology	Ishihara H (1997)	1
RACK1	2	RASA1	3	affinity chromatography technology, pull down	Koehler JA (2001), Koehler JA (2001)	2
NFKBIA	0	YES1	1	affinity chromatography technology	Huttlin EL (2015)	1
KHDRBS1	1	LCK	0	affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology	Fusaki N (1997), Loewenberg M (2006), Tran T (2005), Nervi S (2005)	4
LCK	0	G3BP1	4	enzymatic study	Rahmouni S (2005)	1
DOK2	2	EGFR	5	pull down	Jones N (1999)	1
ERBB2	6	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Scaltriti M (2009), Shtiegman K (2007), Haslekas C (2005), Riedemann J (2007), Burke P (2001), Meijer IM (2011), Chen TC (2014), Li J (2013), Li J (2013), Caiazza F (2010), Caiazza F (2010), Sharif A (2009)	12
SRC	2	ERBB2	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference	Ren Z (2002), Li X (2007), Liang K (2010), Liang K (2010), Shen JP (2017)	5
EGFR	5	PDGFRB	8	affinity chromatography technology	Habib AA (1998)	1
ERBB3	3	CSK	3	affinity chromatography technology	Schulze WX (2006)	1
NCK1	0	OLIG1	0	two hybrid	Grossmann A (2015)	1
RASA1	3	G3BP1	4	affinity chromatography technology	Gallouzi IE (1998)	1
ABL1	9	EGFR	5	unspecified method, two hybrid, protein complementation assay	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	3
EGFR	5	BBS10	2	affinity chromatography technology	Yao Z (2017)	1
RASA1	3	BBS10	2	two hybrid	Vinayagam A (2011)	1
PDGFRA	3	RASA1	3	affinity chromatography technology	Valius M (1993)	1
CAV2	0	RASA1	3	pull down, affinity chromatography technology, affinity chromatography technology	Lee H (2002), Lee H (2002), Lee H (2002)	3
G3BP1	4	APP	1	pull down	Olah J (2011)	1
TRMT2A	4	APP	1	pull down, pull down	Olah J (2011), Virok DP (2011)	2
YES1	1	SOCS3	0	two hybrid	Rolland T (2014)	1
PDGFRA	3	PLCG1	6	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study	Eriksson A (1995), Eriksson A (1995), Chen TC (2014), Valius M (1993), Valius M (1993)	5
EGFR	5	SOCS3	0	affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Xia L (2002), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
XRCC6	3	HTT	14	pull down, two hybrid	Goehler H (2004), Goehler H (2004)	2
NTRK1	1	SRC	2	affinity chromatography technology	Emdal KB (2015)	1
PDGFRB	8	PLCG1	6	affinity chromatography technology, unspecified method	Kashishian A (1993), Liu BA (2012)	2
ERBB2	6	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method	Schulze WX (2006), Bourguignon LY (2001), Olayioye MA (1998), Li X (2007), Li X (2007), Crovello CS (1998), Jones RB (2006)	7
NCK1	0	SOCS1	1	pull down	De Sepulveda P (1999)	1
NTRK1	1	RACK1	2	affinity chromatography technology	Emdal KB (2015)	1
NCK1	0	PDGFRB	8	affinity chromatography technology, affinity chromatography technology	Li W (1992), Braverman LE (1999)	2
KHDRBS1	1	RASA1	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Sanchez-Margalet V (2001), Sanchez-Margalet V (2001), Jabado N (1998), Jabado N (1998), Koch CA (1992), Marengere LE (1992), Gold MR (1993), Darby C (1994)	8
CSK	3	SRC	2	pull down	Sabe H (1994)	1
HCK	5	OLIG1	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
EGFR	5	PLCG1	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Tvorogov D (2002), Bedrin MS (1997), Crovello CS (1998), Choi JH (2003), Jones RB (2006), Tong J (2014), Egan JE (2002), Wu D (2009), Wu D (2009)	9
IGF1R	5	PXN	1	affinity chromatography technology	Manes S (1999)	1
DOK1	2	NCK1	0	unspecified method, affinity chromatography technology	Liu BA (2012), Wick MJ (2001)	2
SOCS1	1	ABL1	9	affinity chromatography technology	Qiu X (2012)	1
IGF1R	5	RACK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hermanto U (2002), He X (2011), He X (2011)	3
LCK	0	ZAP70	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Pelosi M (1999), Thome M (1995), Lupher ML (1996)	3
PLCG1	6	KHDRBS1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Oneyama C (2002), Jabado N (1998), Shen Z (1999), Shen Z (1999), Jabado N (1997), Jabado N (1997)	6
KDR	4	APP	1	pull down, affinity chromatography technology, affinity chromatography technology	Patel NS (2010), Patel NS (2010), Patel NS (2010)	3
EGFR	5	ERBB4	5	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Meijer IM (2013), Kiuchi T (2014), Kiuchi T (2014)	3
FGFR1	2	PLCG1	6	two hybrid, imaging technique, two hybrid, pull down, enzymatic study, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology	Xu H (1998), Chen TC (2014), Hu Y (2004), Shi E (1993), Shi E (1993), Bae JH (2009), Bae JH (2009), Bae JH (2009), Browaeys-Poly E (2010), Browaeys-Poly E (2010), Vecchione A (2007)	11
RASA1	3	TRMT2A	4	two hybrid	Vinayagam A (2011)	1
HCK	5	SRC	2	affinity chromatography technology	Howlett CJ (2002)	1
HNRNPL	3	ANXA6	4	affinity chromatography technology	Fei T (2017)	1
CD5	1	LCK	0	affinity chromatography technology	Bamberger M (2011)	1
EGFR	5	ZAP70	5	unspecified method, two hybrid, protein complementation assay, affinity chromatography technology	Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	4
NTRK1	1	EGFR	5	affinity chromatography technology	Emdal KB (2015)	1
NTRK1	1	INSR	9	affinity chromatography technology	Emdal KB (2015)	1
NFKBIA	0	DNAJA3	2	affinity chromatography technology, pull down	Cheng H (2005), Cheng H (2005)	2
GRB2	2	DNAJA3	2	two hybrid	Wang J (2008)	1
GRB2	2	ARHGAP35	12	affinity chromatography technology	Lamprecht R (2002)	1
EGFR	5	APP	1	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
RASA1	3	DOK1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Dunant NM (2000), Yamanashi Y (1997), Nemorin JG (2000), Liu BA (2012), Di Cristofano A (1998), Bhat A (1998), Wick MJ (2001), Kashige N (2000), Kashige N (2000), Kepley CL (2004)	10
SRC	2	PXN	1	pull down	Angers-Loustau A (1999)	1
NCK1	0	ERBB3	3	unspecified method	Jones RB (2006)	1
GRB2	2	PXN	1	pull down	Angers-Loustau A (1999)	1
ABL1	9	SRC	2	pull down	Yu HH (2001)	1
NCK1	0	MAP4K4	13	pull down, affinity chromatography technology	Su YC (1997), Su YC (1997)	2
ZAP70	5	PLCG1	6	affinity chromatography technology, affinity chromatography technology, pull down	Nel AE (1995), Braiman A (2006), Hubert P (1996)	3
RASA1	3	ERBB4	5	unspecified method	Jones RB (2006)	1
EGFR	5	HCK	5	two hybrid, protein complementation assay	Kotlyar M (2015), Petschnigg J (2014)	2
PTK2B	6	ERBB2	6	affinity chromatography technology, imaging technique	Zrihan-Licht S (2000), Chen TC (2014)	2
ERBB3	3	GRB2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Schulze WX (2006), Crovello CS (1998), Li J (2013)	3
RASA1	3	SRC	2	affinity chromatography technology, enzymatic study	Brott BK (1991), Giglione C (2001)	2
HNRNPL	3	HTT	14	affinity chromatography technology	Fei T (2017)	1
KDR	4	GRB2	2	affinity chromatography technology	DAngelo G (1999)	1
CSK	3	ZAP70	5	pull down	Catipovic B (1996)	1
ZAP70	5	RASA1	3	affinity chromatography technology	Neumeister EN (1995)	1
PLCG1	6	SRC	2	affinity chromatography technology	Dhar A (1994)	1
HNRNPL	3	INSR	9	affinity chromatography technology	Fei T (2017)	1
RASA1	3	APP	1	pull down	Olah J (2011)	1
INSR	9	SOCS1	1	affinity chromatography technology	Mooney RA (2001)	1
FGFR1	2	RASA1	3	pull down	Shi E (1993)	1
KDR	4	NCK1	0	affinity chromatography technology	Ratcliffe KE (2002)	1
NTRK1	1	ABL1	9	two hybrid, affinity chromatography technology, pull down	Koch A (2000), Yano H (2000), Koch A (2000)	3
KDR	4	PLCG1	6	pull down	Cunningham SA (1997)	1
SOCS3	0	RASA1	3	pull down, affinity chromatography technology	Cacalano NA (2001), Cacalano NA (2001)	2
ABL1	9	ERBB2	6	unspecified method	Jones RB (2006)	1
SRC	2	ERBB3	3	unspecified method	Jones RB (2006)	1
BTRC	1	KDR	4	pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study	Meyer RD (2011), Meyer RD (2011), Shaik S (2012), Shaik S (2012)	4
SOCS3	0	NFKBIA	0	affinity chromatography technology, affinity chromatography technology	Nair S (2011), Nair S (2011)	2
ERBB3	3	ZAP70	5	unspecified method	Jones RB (2006)	1
ABL1	9	GRB2	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Warmuth M (1997), Ren R (1994), Ren R (1994), Patel H (2006), Johnson KJ (2009), Gaston I (2004), Gaston I (2004), Brehme M (2009), Brehme M (2009), Chen R (2013), Feller SM (1994)	11
ABL1	9	NFKBIA	0	affinity chromatography technology, pull down	Kawai H (2002), Kawai H (2002)	2
HCK	5	APP	1	pull down	Olah J (2011)	1
FGFR1	2	NCK1	0	unspecified method	Liu BA (2012)	1
EGFR	5	PDGFRA	3	two hybrid, protein complementation assay, affinity chromatography technology	Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	3
INSR	9	DOK1	2	enzymatic study	Wick MJ (2001)	1
RASA1	3	EPHB3	4	pull down, affinity chromatography technology, affinity chromatography technology	Hock B (1998), Hock B (1998), Hock B (1998)	3
SOCS3	0	IGF1R	5	pull down, two hybrid, affinity chromatography technology	Dey BR (2000), Dey BR (2000), Dey BR (2000)	3
SRC	2	GRB2	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Saci A (2002)	2
NCK1	0	ABL1	9	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Miyoshi-Akiyama T (2001), Ren R (1994), Ren R (1994), Wunderlich L (1999), Adler CE (2000)	5
LCK	0	SOCS3	0	affinity chromatography technology	Venkitachalam S (2011)	1
DOK1	2	ABL1	9	pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	van Dijk TB (2000), Yamanashi Y (1997), Yamanashi Y (1997), Johnson KJ (2009), Liu BA (2012), Bhat A (1998), Bhat A (1998), Bhat A (1998), Kashige N (2000)	9
RASA1	3	SOCS1	1	affinity chromatography technology, affinity chromatography technology	Madonna S (2008), Madonna S (2008)	2
CSK	3	KHDRBS1	1	enzymatic study, affinity chromatography technology, biochemical	Taylor SJ (1994), Taylor SJ (1994), Taylor SJ (1994)	3
RASA1	3	NFKBIA	0	genetic interference	Spiegelman VS (2002)	1
CSK	3	PXN	1	affinity chromatography technology	Bergman M (1995)	1
NCK1	0	EGFR	5	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, two hybrid, protein complementation assay	Tang J (1997), Li W (1992), Braverman LE (1999), Jones RB (2006), Kotlyar M (2015), Petschnigg J (2014)	6
IGF1R	5	ERBB2	6	affinity chromatography technology	Riedemann J (2007)	1
INSR	9	SOCS3	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Senn JJ (2003), Calegari VC (2005), Calegari VC (2005)	3
NTRK1	1	PDGFRA	3	affinity chromatography technology	Emdal KB (2015)	1
RASA1	3	SERPINA4	0	two hybrid	Vinayagam A (2011)	1
SRC	2	EPHB2	10	two hybrid, two hybrid, pull down, pull down, affinity chromatography technology, pull down	Zisch AH (1998), Zisch AH (2000), Zisch AH (2000), Zisch AH (1998), Zisch AH (1998), Zisch AH (1998)	6
EPHB2	10	YES1	1	pull down	Zisch AH (1998)	1
RASA1	3	ERBB3	3	unspecified method	Jones RB (2006)	1
INSR	9	PLCG1	6	unspecified method	Liu BA (2012)	1
SLC9A2	1	ABL1	9	pull down	Chow CW (1999)	1
SOCS3	0	PTK2B	6	two hybrid, affinity chromatography technology	Masuhara M (1997), Zhang S (2008)	2
GRB2	2	RASA1	3	affinity chromatography technology	Lamprecht R (2002)	1
ERBB2	6	RASA1	3	unspecified method	Jones RB (2006)	1
ERBB4	5	ERBB2	6	affinity chromatography technology	Huang YZ (2000)	1
G3BP1	4	YES1	1	affinity chromatography technology	Jain S (2016)	1
G3BP1	4	ANXA6	4	affinity chromatography technology	Jain S (2016)	1
HNRNPL	3	ERBB2	6	affinity chromatography technology	Fei T (2017)	1
ERBB2	6	ANXA6	4	two hybrid	Arroyo R (2015)	1
IGF1R	5	RASA1	3	affinity chromatography technology, pull down	Seely BL (1995), Seely BL (1995)	2
DOK1	2	DOK2	2	affinity chromatography technology	Dunant NM (2000)	1
DNAJA3	2	RASA1	3	affinity chromatography technology, pull down	Trentin GA (2001), Trentin GA (2001)	2
NTRK1	1	XRCC6	3	affinity chromatography technology	Emdal KB (2015)	1
PLCG1	6	ERBB3	3	unspecified method	Jones RB (2006)	1
HNRNPL	3	ARHGAP35	12	affinity chromatography technology	Fei T (2017)	1
ERBB4	5	NCK1	0	affinity chromatography technology	Schulze WX (2006)	1
PLCG1	6	GRB2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Pei Z (1997), Pei Z (1997), Nel AE (1995), Scholler JK (2000), Choi JH (2005), Choi JH (2005)	6
SOCS3	0	APP	1	pull down	Olah J (2011)	1
PXN	1	LCK	0	affinity chromatography technology	Ostergaard HL (1998)	1
GRB2	2	DOK1	2	affinity chromatography technology	Kepley CL (2004)	1
EZH2	4	KHDRBS1	1	affinity chromatography technology	Cao Q (2014)	1
INSR	9	RASA1	3	affinity chromatography technology	Pronk GJ (1992)	1
PDGFRA	3	GRB2	2	affinity chromatography technology, affinity chromatography technology	Bazenet CE (1996), Severe N (2011)	2
ZAP70	5	GRB2	2	affinity chromatography technology, affinity chromatography technology	Nel AE (1995), Jin HS (2013)	2
GRB2	2	NTRK1	1	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Song C (2002), MacDonald JI (2000), Emdal KB (2015), Emdal KB (2015)	4
HCK	5	RASA1	3	affinity chromatography technology, pull down	Briggs SD (1995), Briggs SD (1995)	2
EPHB2	10	ABL1	9	affinity chromatography technology, pull down, two hybrid	Yu HH (2001), Yu HH (2001), Yu HH (2001)	3
GRB2	2	PDGFRB	8	pull down, pull down, affinity chromatography technology	Arvidsson AK (1994), Tang J (1997), Braverman LE (1999)	3
XRCC6	3	ABL1	9	affinity chromatography technology, affinity chromatography technology	Kumaravel TS (1998), So J (2015)	2
DOK1	2	HCK	5	pull down	van Dijk TB (2000)	1
NTRK1	1	ANXA6	4	affinity chromatography technology	Emdal KB (2015)	1
ARHGAP35	12	RASA1	3	pull down, affinity chromatography technology, affinity chromatography technology	Hu KQ (1997), Gold MR (1993), Darby C (1994)	3
PDGFRA	3	ERBB2	6	fluorescent resonance energy transfe	Ivanov AA (2017)	1
HNRNPL	3	PLCG1	6	affinity chromatography technology	Fei T (2017)	1
EPHB2	10	PLCG1	6	two hybrid	Zisch AH (1998)	1
RASA1	3	XRCC6	3	two hybrid	Vinayagam A (2011)	1
EGFR	5	SOCS1	1	affinity chromatography technology	Xia L (2002)	1
DOK2	2	NCK1	0	affinity chromatography technology	Master Z (2001)	1
CAV2	0	SRC	2	pull down	Lee H (2002)	1
HTT	14	GRB2	2	affinity chromatography technology, pull down	Liu YF (1997), Liu YF (1997)	2
EPHB2	10	RASA1	3	affinity chromatography technology, pull down, pull down	Holland SJ (1997), Holland SJ (1997), Zisch AH (2000)	3
EGFR	5	ERBB3	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Marques MM (1999), Li J (2013), Li J (2013), Sharif A (2009)	4
RASA1	3	YES1	1	affinity chromatography technology	Cichowski K (1992)	1
SOCS3	0	ABL1	9	affinity chromatography technology	Qiu X (2012)	1
BTRC	1	NFKBIA	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, enzymatic study, enzymatic study, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, bioid, enzymatic study, protein complementation assay	Suzuki H (2000), Spencer E (1999), Spencer E (1999), Spencer E (1999), Suzuki H (1999), Suzuki H (1999), Kroll M (1999), Kroll M (1999), Yaron A (1998), Choi YS (2010), Banerjee S (2010), Banerjee S (2010), Banerjee S (2010), Da Silva-Ferrada E (2011), Tsuchiya Y (2010), Tsuchiya Y (2010), Keutgens A (2010), Winston JT (1999), Winston JT (1999), Winston JT (1999), Winston JT (1999), Surjit M (2012), Busino L (2012), Evrard-Todeschi N (2008), Furukawa M (2000), Kovacev J (2014), Chong RA (2014), Chong RA (2014), Shi M (2014), Shirane M (1999), Read MA (2000), Tan M (2010), Coyaud E (2015), Coyaud E (2015), Wu K (2016), Villalobos V (2010)	36
PDGFRB	8	RASA1	3	affinity chromatography technology, affinity chromatography technology	Farooqui T (2000), Ekman S (2002)	2
ABL1	9	ERBB4	5	unspecified method	Jones RB (2006)	1
PDGFRA	3	PDGFRB	8	affinity chromatography technology, pull down, affinity chromatography technology	Rupp E (1994), Seifert RA (1989), Huttlin EL (2017)	3
SOCS1	1	IGF1R	5	two hybrid	Dey BR (1998)	1
ABL1	9	ERBB3	3	unspecified method	Jones RB (2006)	1
GRB2	2	CSK	3	affinity chromatography technology	Bisson N (2011)	1
YES1	1	OLIG1	0	two hybrid, affinity chromatography technology	Grossmann A (2015), Grossmann A (2015)	2
LCK	0	RASA1	3	enzymatic study	Giglione C (2001)	1
CSK	3	INSR	9	two hybrid	Arbet-Engels C (1999)	1
SRC	2	KDR	4	affinity chromatography technology, affinity chromatography technology, unspecified method	Meyer RD (2008), Gavard J (2008), Sun Z (2012)	3
NCK1	0	KHDRBS1	1	pull down, far western blotting, affinity chromatography technology, unspecified method, affinity chromatography technology	Tang J (1997), Lawe DC (1997), Lawe DC (1997), Asbach B (2012), Asbach B (2012)	5
G3BP1	4	MAP4K4	13	affinity chromatography technology	Jain S (2016)	1