PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
MARK3	2	RASGRF1	4	pull down, affinity chromatography technology	Peng CY (1998), Peng CY (1998)	2
MYC	2	RASGRF1	4	genetic interference	Toyoshima M (2012)	1
MYC	2	SNRNP70	2	pull down	Miyamoto-Sato E (2010)	1
CEBPA	0	RASGRF1	4	two hybrid	Wang J (2011)	1
GRK2	4	RASGRF1	4	two hybrid	Wang J (2011)	1
RASGRF1	4	SNRNP70	2	two hybrid	Wang J (2011)	1
SRPK2	1	SNRNP70	2	enzymatic study, two hybrid, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology	Wang HY (1998), Hegele A (2012), Hegele A (2012), Varjosalo M (2013), Varjosalo M (2013), Lipp JJ (2015), Huttlin EL (2017)	7
SRPK2	1	SRC	2	enzymatic study	Lipp JJ (2015)	1
SRC	2	RASGRF1	4	enzymatic study	Giglione C (2001)	1
MYC	2	YWHAB	1	affinity chromatography technology	Koch HB (2007)	1
YWHAB	1	MARK3	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ewing RM (2007), Jin J (2004), Couzens AL (2013), Nichols RJ (2010)	4
HRAS	2	RASGRF1	4	two hybrid	Stang S (1997)	1
PPP1R9B	1	RASGRF1	4	affinity chromatography technology	Buchsbaum RJ (2003)	1
SRPK2	1	RASGRF1	4	enzymatic study	Lipp JJ (2015)	1
MYC	2	CEBPA	0	affinity chromatography technology	Tinel M (2003)	1
RASGRF1	4	YWHAB	1	pull down	Peng CY (1998)	1
SRPK2	1	YWHAB	1	enzymatic study, affinity chromatography technology	Varjosalo M (2013), Jang SW (2009)	2
EHD4	1	RASGRF1	4	two hybrid	Wang J (2011)	1
GRK2	4	SRC	2	affinity chromatography technology, affinity chromatography technology	Wan KF (2003), Wan KF (2003)	2