PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CCNE1	1	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Harbour JW (1999), Manenti S (1999), Horton LE (1997), Higashi H (1996), Jiang W (1998), Connell-Crowley L (1997), Gaiddon C (2003), Zarkowska T (1997), Nakanishi M (1999)	9
BRMS1	1	SAP30	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meehan WJ (2004), Meehan WJ (2004), Hein MY (2015)	3
SIN3A	13	SAP30	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, affinity chromatography technology, affinity chromatography technology	Fleischer TC (2003), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1999), Yochum GS (2001), Kuzmichev A (2002), Kuzmichev A (2002), Kuzmichev A (2002), Laherty CD (1998), Viiri KM (2006), Viiri KM (2006), Nakamura T (2002), Lai A (2001), Skowyra D (2001), Zhang Y (1998), Zhang Y (1998), Xie T (2011), Xie T (2011), Bantscheff M (2011), Hein MY (2015)	21
SAP30	1	FOXK1	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Li X (2015)	2
SIN3B	5	SIN3A	13	affinity chromatography technology	Hein MY (2015)	1
HDAC1	4	GATAD1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Vermeulen M (2010), Hein MY (2015), Varier RA (2016), Huttlin EL (2017)	5
SIN3B	5	ARID4A	3	affinity chromatography technology, affinity chromatography technology	Lai A (2001), Lai A (2001)	2
RBBP4	3	SIN3B	5	affinity chromatography technology	Hauri S (2016)	1
CDK2	0	RBL1	1	enzymatic study, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Leng X (2002), Zhao J (1998), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Huttlin EL (2017)	8
CCNB1	3	CDK2	0	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Di Fiore B (2010), Nishiyama A (2000), Wolthuis R (2008), Desai D (1995), Varjosalo M (2013), Varjosalo M (2013), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	11
FOXK1	5	RBL1	1	affinity chromatography technology	Li X (2015)	1
RBL1	1	CCNA2	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dyson N (1993), Joaquin M (2002), Gibbs E (1996), Schulman BA (1998), Schulman BA (1998), Huttlin EL (2015), Huttlin EL (2017)	7
SIN3A	13	HBP1	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology	Swanson KA (2004), Swanson KA (2004), Swanson KA (2004), Swanson KA (2004), Swanson KA (2004), Lampert F (2018), Lampert F (2018)	7
HBP1	1	SINHCAF	0	affinity chromatography technology	Lampert F (2018)	1
HDAC1	4	SIN3B	5	biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1999), Koipally J (1999), Romm E (2005), Humphrey GW (2001), Terhune SS (2010), Joshi P (2013), Wan C (2015), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	10
CDK4	2	RBL1	1	enzymatic study	Anders L (2011)	1
GATAD1	0	SIN3B	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Hein MY (2015), Hein MY (2015), Varier RA (2016)	4
CCNA2	1	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Horton LE (1997), Higashi H (1996), Knudsen ES (1996), Jiang W (1998), Connell-Crowley L (1997), Gaiddon C (2003), Nakanishi M (1999)	7
ARID4B	1	SAP30	1	biochemical, affinity chromatography technology	Wan C (2015), Hein MY (2015)	2
ING2	0	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Huttlin EL (2015), Huttlin EL (2017)	4
FOXK2	9	RBBP4	3	pull down	Shan L (2016)	1
CCNE1	1	RBL1	1	affinity chromatography technology	Shanahan F (1999)	1
ZNF704	2	ARID4B	1	affinity chromatography technology	Huttlin EL (2017)	1
HDAC1	4	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Yao YL (2003), Fleischer TC (2003), Fleischer TC (2003), Yang L (2003), Grozinger CM (1999), Zhang J (2002), Zhang J (2002), You A (2001), Zhang Y (1999), Zhang Y (2002), Tong JK (1998), Hassig CA (1998), Yasui D (2002), Huang EY (2000), Huang EY (2000), Kuzmichev A (2002), Kuzmichev A (2002), Martinowich K (2003), Martinowich K (2003), Suzuki M (2003), Suzuki M (2006), Nakamura T (2002), Wei Q (2005), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Skowyra D (2001), Humphrey GW (2001), Sekhavat A (2007), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Bantscheff M (2011), Bantscheff M (2011), Joshi P (2013), Oh YM (2009), Wan C (2015), Hein MY (2015), Hsu DS (2014), Huttlin EL (2017)	45
FOXK2	9	SIN3B	5	affinity chromatography technology	Li X (2015)	1
SINHCAF	0	FOXK2	9	affinity chromatography technology	Huttlin EL (2017)	1
HDAC1	4	SINHCAF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	3
CDK2	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Shintani S (2000), Nair JS (2009), Takaki T (2004), Shen WH (2004), He W (2003), Peiretti A (2003), Harbour JW (1999), Horton LE (1997), Higashi H (1996), Delston RB (2011), Kim KS (2002), Chen W (2004), Liberal V (2012), Boyer Arnold N (2005), Dynlacht BD (1997), Knudsen ES (1996), Jiang W (1998), De Luca A (1997), Chen Z (2002), Hara E (1997), Connell-Crowley L (1997), Matsuura I (2004), Chen J (1996), Gaiddon C (2003), Seo DW (2006), Zarkowska T (1997), Grimmler M (2007), Nakanishi M (1999), Pevarello P (2005), Iyer NG (2007), Chan HM (2001), Pan W (2001)	32
ING2	0	ARID4B	1	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Huttlin EL (2017)	2
CCNE1	1	CDK4	2	affinity chromatography technology, fluorescent resonance energy transfe	Datta NS (1998), Ivanov AA (2017)	2
SIN3A	13	ARID4A	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Lai A (2001), Lai A (2001), Suryadinata R (2011), Wan C (2015)	4
SAP30	1	RBBP7	1	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Zhang Y (1999), Kuzmichev A (2002), Lai A (2001), Zhang Y (1998), Zhang Y (1998), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	11
HBP1	1	RBBP7	1	affinity chromatography technology	Lampert F (2018)	1
ARID4A	3	ARID4B	1	affinity chromatography technology	Wu MY (2006)	1
MXD1	2	ARID4A	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HBP1	1	ING2	0	affinity chromatography technology	Lampert F (2018)	1
ARID4A	3	RBBP4	3	affinity chromatography technology	Lai A (2001)	1
FOXK2	9	ARID4B	1	affinity chromatography technology	Li X (2015)	1
RBBP7	1	SIN3B	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	4
ARID4A	3	CCND1	1	enzymatic study	Suryadinata R (2011)	1
HBP1	1	ARID4A	3	affinity chromatography technology	Lampert F (2018)	1
ZNF704	2	ARID4A	3	affinity chromatography technology	Huttlin EL (2017)	1
GATAD1	0	ING2	0	affinity chromatography technology	Varier RA (2016)	1
RBBP7	1	HIST4H4	1	affinity chromatography technology	Campos EI (2010)	1
ARID4A	3	CCNE1	1	enzymatic study	Suryadinata R (2011)	1
HBP1	1	RB1	2	two hybrid, pull down, affinity chromatography technology	Lavender P (1997), Lavender P (1997), Lavender P (1997)	3
CCNA2	1	CDK4	2	affinity chromatography technology, affinity chromatography technology	Datta NS (1998), Kikuchi R (2014)	2
ZNF704	2	ING2	0	affinity chromatography technology	Huttlin EL (2017)	1
GATAD1	0	ARID4A	3	affinity chromatography technology	Varier RA (2016)	1
FOXK2	9	ING2	0	affinity chromatography technology	Li X (2015)	1
FOXK2	9	ARID4A	3	affinity chromatography technology	Li X (2015)	1
HDAC1	4	BRMS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu Y (2006), Hurst DR (2006), Bantscheff M (2011), Joshi P (2013), Meehan WJ (2004), Meehan WJ (2004), Hein MY (2015), Huttlin EL (2017)	8
CDK2	0	CDK1	0	affinity chromatography technology, affinity chromatography technology	Neganova I (2011), Huttlin EL (2017)	2
SINHCAF	0	SIN3A	13	affinity chromatography technology	Huttlin EL (2017)	1
FOXK1	5	FOXK2	9	affinity chromatography technology	Li X (2015)	1
BRMS1	1	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meehan WJ (2004), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	4
CCNB1	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Lin Z (2015), Lin Z (2015)	2
ARID4A	3	CDK2	0	enzymatic study	Suryadinata R (2011)	1
HBP1	1	BRMS1	1	affinity chromatography technology	Lampert F (2018)	1
8339	0	ARID4B	1	bioid	Lambert JP (2015)	1
CCNA2	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Amador V (2007), Horton LE (1997), Lin ML (2011), Lin ML (2011), OConnor PM (1993), Varjosalo M (2013), Kikuchi R (2014), Mateo F (2009), So J (2015), Huttlin EL (2015), Hein MY (2015), Huttlin EL (2017)	13
RBBP4	3	RBBP7	1	biochemical, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Kristensen AR (2012), Huttlin EL (2015), Wan C (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	7
ARID4B	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fleischer TC (2003), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	4
FOXK2	9	BRMS1	1	affinity chromatography technology	Li X (2015)	1
SAP30	1	FOXK2	9	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Hein MY (2015), Li X (2015), Shan L (2016), Shan L (2016), Shan L (2016)	5
RB1	2	HDAC1	4	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Dick FA (2000), Fuks F (2000), Puri PL (2001), Puri PL (2001), Wang S (2002), Luo RX (1998), Luo RX (1998), Lai A (1999), Lai A (1999), Ferreira R (1998), Kimura H (2003), Qiu Z (2008), Fedele M (2006), Brown VD (2002), Khan MM (2001), Dasgupta P (2004), Chang YC (2001), Dahiya A (2000), Zhang HS (2000), Tokitou F (1999), Nguyen DX (2004), Takaki T (2004), Magnaghi-Jaulin L (1998), Magnaghi-Jaulin L (1998), Brehm A (1998), Brehm A (1998), Brehm A (1998), Sun JM (2007), Fan LX (2012), Harbour JW (1999), Brehm A (1999), Joshi P (2013), Chen TT (2000), Chen TT (2000), Chen TT (2000), Chen TT (2000)	36
8339	0	ARID4A	3	bioid	Lambert JP (2015)	1
ARID4A	3	CDK4	2	enzymatic study	Suryadinata R (2011)	1
ING2	0	SAP30	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Hein MY (2015), Huttlin EL (2017)	3
HDAC1	4	HBP1	1	affinity chromatography technology, affinity chromatography technology	Swanson KA (2004), Lampert F (2018)	2
SINHCAF	0	ARID4B	1	affinity chromatography technology	Huttlin EL (2017)	1
ING2	0	BRMS1	1	affinity chromatography technology	Huttlin EL (2017)	1
ARID4A	3	HIST4H4	1	pull down	Gong W (2012)	1
ARID4A	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lai A (2001), Joshi P (2013), Hein MY (2015), Huttlin EL (2017)	4
FOXK1	5	BRMS1	1	affinity chromatography technology	Li X (2015)	1
HBP1	1	ARID4B	1	affinity chromatography technology	Lampert F (2018)	1
ZNF704	2	SIN3A	13	affinity chromatography technology	Huttlin EL (2017)	1
SINHCAF	0	FOXK1	5	affinity chromatography technology	Huttlin EL (2017)	1
ARID4A	3	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lai A (2001), Huttlin EL (2015), Huttlin EL (2017)	3
FOXK1	5	SIN3A	13	affinity chromatography technology	Li X (2015)	1
SIN3A	13	BRMS1	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Bantscheff M (2011), Hurst DR (2013), Meehan WJ (2004), Meehan WJ (2004)	4
CDK4	2	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Nair JS (2009), Takaki T (2004), Deep G (2006), Kehn K (2004), Scholz A (2003), Gladden AB (2003), Mori S (1999), Higashi H (1996), Musgrove EA (1996), Sarmento LM (2005), Kim KS (2002), Li J (2002), Garcia-Morales P (2006), Tsai CH (2009), Miralem T (2003), Toji S (2004), Halder SK (2005), Dynlacht BD (1997), Mandal M (1998), Voit R (1999), Annicotte JS (2006), Connell-Crowley L (1997), Matsuura I (2004), Chen J (1996), Kitagawa M (1996), Anders L (2011), Gaiddon C (2003), Seo DW (2006), Kabuta T (2013), Lee B (2006), Kossatz U (2006), Zarkowska T (1997), Nakanishi M (1999), Iyer NG (2007), Guidoboni M (2005), Barbash O (2009), Wang C (2001), Denicourt C (2008), Pan W (2001)	39
SINHCAF	0	BRMS1	1	affinity chromatography technology	Huttlin EL (2017)	1
MXD1	2	ARID4B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
FOXK2	9	SIN3A	13	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, pull down	Li X (2015), Ji Z (2014), Ji Z (2014), Shan L (2016), Shan L (2016), Shan L (2016), Shan L (2016)	7
SAP30	1	ARID4A	3	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology	Lai A (2001), Lai A (2001), Suryadinata R (2011), Suryadinata R (2011), Hein MY (2015)	5
SAP30	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, biochemical, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huang NE (2003), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1999), Zhang Y (1999), Swanson KA (2004), Yochum GS (2001), Kuzmichev A (2002), Kuzmichev A (2002), Viiri KM (2006), Binda O (2008), Lai A (2001), Skowyra D (2001), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Xue Y (1998), Bantscheff M (2011), Joshi P (2013), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	24
ARID4A	3	CDK1	0	enzymatic study	Suryadinata R (2011)	1
GATAD1	0	BRMS1	1	affinity chromatography technology	Varier RA (2016)	1
ARID4A	3	CCNB1	3	enzymatic study	Suryadinata R (2011)	1
GATAD1	0	SIN3A	13	affinity chromatography technology	Varier RA (2016)	1
CCND1	1	RB1	2	pull down, genetic interference, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Siegert JL (2000), Siegert JL (2000), Dowdy SF (1993), Chan HM (2001), Dasgupta P (2004), Dasgupta P (2004), Sweeney KJ (1997), Higashi H (1996), Musgrove EA (1996), Yarbrough WG (1999), Connell-Crowley L (1997), Kitagawa M (1996), Poon RY (1996), Gaiddon C (2003), Zarkowska T (1997), Nakanishi M (1999), Welcker M (1998)	17
CCNE1	1	CDK1	0	affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Koff A (1992), Koff A (1992), Horton LE (1997)	4
CDK4	2	HDAC1	4	genetic interference	Shen JP (2017)	1
BRMS1	1	RBBP4	3	affinity chromatography technology	Meehan WJ (2004)	1
ZNF704	2	BRMS1	1	affinity chromatography technology	Huttlin EL (2017)	1
FOXK1	5	ING2	0	affinity chromatography technology	Li X (2015)	1
ING2	0	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006)	2
MXD1	2	SAP30	1	pull down	Spronk CA (2000)	1
HBP1	1	SAP30	1	affinity chromatography technology	Lampert F (2018)	1
GATAD1	0	RBBP4	3	affinity chromatography technology	Varier RA (2016)	1
ING2	0	SIN3B	5	affinity chromatography technology	Huttlin EL (2017)	1
FOXK1	5	ARID4B	1	affinity chromatography technology	Li X (2015)	1
FOXK2	9	RB1	2	affinity chromatography technology	Li X (2015)	1
SIN3A	13	ARID4B	1	affinity chromatography technology, affinity chromatography technology, biochemical	Fleischer TC (2003), Fleischer TC (2003), Wan C (2015)	3
CCND1	1	CDK2	0	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sweeney KJ (1997), Higashi H (1996), Higashi H (1996), Varjosalo M (2013), Hein MY (2015), Huttlin EL (2017)	6
SINHCAF	0	ING2	0	affinity chromatography technology	Huttlin EL (2017)	1
RBBP7	1	SIN3A	13	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1998), Kuzmichev A (2002), Nakamura T (2002), Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	6
GATAD1	0	SAP30	1	affinity chromatography technology	Varier RA (2016)	1
GATAD1	0	RBBP7	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Vermeulen M (2010), Huttlin EL (2015), Hein MY (2015), Varier RA (2016), Huttlin EL (2017)	5
SAP30	1	SIN3B	5	biochemical, affinity chromatography technology, affinity chromatography technology	Zhang Y (1999), Hein MY (2015), Hein MY (2015)	3
SINHCAF	0	SIN3B	5	affinity chromatography technology	Huttlin EL (2017)	1
RBBP7	1	ARID4B	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CCNB1	3	RB1	2	enzymatic study, enzymatic study	Jiang W (1998), Knudsen ES (1997)	2
ARID4A	3	HIST2H3C	0	pull down	Gong W (2012)	1
RBBP7	1	FOXK1	5	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SINHCAF	0	ARID4A	3	affinity chromatography technology	Huttlin EL (2017)	1
SIN3A	13	RBBP4	3	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hassig CA (1997), Zhang Y (1998), Nakamura T (2002), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Bantscheff M (2011), Hauri S (2016)	8
SINHCAF	0	RBBP4	3	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2017), Hauri S (2016)	2
FOXK1	5	ARID4A	3	affinity chromatography technology	Li X (2015)	1
MXD1	2	BRMS1	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
GATAD1	0	FOXK1	5	affinity chromatography technology	Varier RA (2016)	1
CCND1	1	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang H (1993), Zhang H (1993), Hein MY (2015), Huttlin EL (2017)	4
CCNB1	3	CDK1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Shanahan F (1999), Yang Q (2000), Pines J (1989), Kong M (2000), Amador V (2007), Paulsen MT (2006), Niida H (2005), Pereg Y (2010), Tamura D (2010), Kiviharju-af Haellstroem TM (2007), Pan ZQ (1993), Pan ZQ (1993), Pan ZQ (1993), van Zon W (2010), Desai D (1995), Vazquez-Novelle MD (2010), Smith EM (2008), Poon RY (1996), OConnor PM (1993), Fosbrink M (2009), Linares JF (2011), Varjosalo M (2013), Felzien LK (1998), Toby GG (2003), So J (2015), Huttlin EL (2015), Wan C (2015), Jenkins RH (2014), Hein MY (2015), Hein MY (2015), Voets E (2015), Lin Z (2015), Lin Z (2015), Huttlin EL (2017)	34
SIN3A	13	MXD1	2	pull down, x-ray crystallography, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Swanson KA (2004), Swanson KA (2004), Brubaker K (2000), Ayer DE (1995), Farias EF (2010), Huttlin EL (2015), Huttlin EL (2017), Cheng J (2017)	8
CDK1	0	RB1	2	enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Horton LE (1997), Lees JA (1991), Knudsen ES (1996), Jiang W (1998), De Luca A (1997), Chen Z (2002), Knudsen ES (1997), Pan W (2001)	8
BRMS1	1	ARID4A	3	affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Hurst DR (2008), Hurst DR (2006), Meehan WJ (2004), Meehan WJ (2004)	4
ING2	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Shi X (2006), Binda O (2008), Joshi P (2013), Huttlin EL (2017)	6
RB1	2	HIST4H4	1	imaging technique	Ianari A (2009)	1
CCNA2	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Henneke G (2003), Naderi S (2005), Varshochi R (2005), Di Fiore B (2010), Mateo F (2009), Abbas T (2007), Schulman BA (1998), Datta NS (1998), Wu G (1997), Sebastian B (1993), Liu S (2009), Ciarallo S (2002), Wolthuis R (2008), Vicent GP (2011), Zhang H (1995), Sayle KL (2003), Jeffrey PD (1995), Davies TG (2001), Cook A (2002), Pevarello P (2006), Levkau B (1998), Poon RY (1996), OConnor PM (1993), Davies TG (2002), Kontopidis G (2003), Andrews MJ (2004), Pevarello P (2004), Pevarello P (2005), Varjosalo M (2013), Varjosalo M (2013), Kikuchi R (2014), Kikuchi R (2014), Mateo F (2009), So J (2015), Okamoto K (2002), Song MS (2011), Huttlin EL (2015), Di Fiore B (2015), Pan ZQ (1993), Pan ZQ (1993), Hein MY (2015), Hein MY (2015), Huttlin EL (2017)	43
ING2	0	SIN3A	13	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Doyon Y (2006), Shi X (2006), Huttlin EL (2017)	4
RB1	2	RBBP7	1	pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Yarden RI (1999), Qian YW (1995), Qian YW (1995), Lai A (2001), Huang S (1991)	5
GATAD1	0	SINHCAF	0	affinity chromatography technology	Varier RA (2016)	1
ZNF704	2	SAP30	1	affinity chromatography technology	Huttlin EL (2017)	1
HDAC1	4	RBBP7	1	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Ng HH (1999), Zhang Y (1999), Zhang Y (1997), Banach-Orlowska M (2009), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Xue Y (1998), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Huttlin EL (2015), Wan C (2015), Hein MY (2015), Yeh HH (2015), Yeh HH (2015), Huttlin EL (2017), Hauri S (2016)	19
RBBP7	1	SINHCAF	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017), Hauri S (2016)	3
RBBP4	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (2003), Yao YL (2003), Nicolas E (2001), Nicolas E (2001), Grozinger CM (1999), You A (2001), Hassig CA (1997), Hassig CA (1997), Ng HH (1999), Zhang Y (1999), Zhang Y (2002), Hassig CA (1998), Zhang Y (1997), Banach-Orlowska M (2009), Pflum MK (2001), Pflum MK (2001), Skowyra D (2001), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Sun JM (2007), Sun JM (2007), Karwowska-Desaulniers P (2007), Terhune SS (2010), Xue Y (1998), Xue Y (1998), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017), Hauri S (2016)	35
8339	0	CCNA2	1	bioid	Lambert JP (2015)	1
HDAC1	4	FOXK1	5	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
MXD1	2	HDAC1	4	pull down	Spronk CA (2000)	1
HDAC1	4	RBL1	1	affinity chromatography technology, affinity chromatography technology, pull down	Lai A (1999), Ferreira R (1998), Ferreira R (1998)	3
CDK4	2	CCND1	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Sugimoto M (1999), Sugimoto M (1999), Serrano M (1993), Lin J (2001), Taules M (1998), Cariou S (2000), Coleman KG (1997), Jose-Eneriz ES (2008), Jose-Eneriz ES (2008), Diehl JA (1997), Okabe H (2007), Bustany S (2011), Gladden AB (2003), Sweeney KJ (1997), Musgrove EA (1996), Vlach J (1996), Garcia-Morales P (2006), Bindra RS (2002), Ruas M (2007), Poon RY (1996), Ramachandran N (2004), Larrea MD (2009), Waaijers S (2013), Mallampalli RK (2013), Rolland T (2014), Chen TC (2014), Barbash O (2009), Datta D (2015), Hukkelhoven E (2012), Hukkelhoven E (2012), Ghiani C (2001), Ito H (2016), Huttlin EL (2017), Roessig L (2001), Qie S (2017)	35
RBBP7	1	FOXK2	9	affinity chromatography technology, affinity chromatography technology, pull down	Huttlin EL (2015), Huttlin EL (2017), Shan L (2016)	3
ARID4A	3	CCNA2	1	enzymatic study	Suryadinata R (2011)	1
ARID4A	3	RB1	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Lai A (1999), Lai A (1999), Lai A (2001), Lai A (2001), Suryadinata R (2011), Suryadinata R (2011)	6
ING2	0	ARID4A	3	affinity chromatography technology, affinity chromatography technology	Doyon Y (2006), Huttlin EL (2017)	2
GATAD1	0	ARID4B	1	affinity chromatography technology	Varier RA (2016)	1
ARID4A	3	RBL1	1	affinity chromatography technology	Lai A (1999)	1
HDAC1	4	CCND1	1	affinity chromatography technology, imaging technique, affinity chromatography technology	Fu M (2005), Fu M (2005), Batra S (2010)	3
SAP30	1	SINHCAF	0	affinity chromatography technology, affinity chromatography technology	Hein MY (2015), Huttlin EL (2017)	2
FOXK2	9	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical	Ji Z (2014), Huttlin EL (2017), Shan L (2016), Shan L (2016), Shan L (2016)	5
HIST4H4	1	RBBP4	3	pull down	Alqarni SS (2014)	1
FOXK1	5	RB1	2	affinity chromatography technology	Li X (2015)	1
BRMS1	1	SIN3B	5	affinity chromatography technology, affinity chromatography technology	Meehan WJ (2004), Meehan WJ (2004)	2
RB1	2	RBBP4	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Nicolas E (2001), Qian YW (1995), Nicolas E (2000), Nicolas E (2000), Lai A (2001), OConnor MD (2011), Qian YW (1993), Qian YW (1993), Qian YW (1993)	9
CCNE1	1	CDK2	0	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	McKenzie PP (2003), Shanahan F (1999), Koff A (1992), Koff A (1992), Mayer C (2004), Connor MK (2003), Boudrez A (2000), Varshochi R (2005), Jeong JH (2010), Bustany S (2011), Yeh ES (2006), Hui S (2011), Kim J (2007), Kiviharju-af Haellstroem TM (2007), Abbas T (2007), Nishimura T (2005), Matsumoto Y (2004), Harwell RM (2004), Harwell RM (2004), Peiretti A (2003), Peiretti A (2003), Kim YB (2000), Manenti S (1999), Datta NS (1998), Sheaff RJ (1997), Higashi H (1996), Higashi H (1996), Musgrove EA (1996), Vlach J (1996), Grim JE (2008), Liu S (2009), Ciarallo S (2002), Desai D (1995), Baydoun HH (2010), Baydoun HH (2010), Chu I (2007), Chu I (2007), Levkau B (1998), Poon RY (1996), Zhao J (1998), Zhao J (1998), Larrea MD (2009), Varjosalo M (2013), Varjosalo M (2013), Chan HM (2001), So J (2015), Ungermannova D (2005), Song MS (2011), Huttlin EL (2015), Hein MY (2015), Lin CH (2015), Lin CH (2015), Davis RJ (2017), Huttlin EL (2017)	54
SAP30	1	RBBP4	3	affinity chromatography technology, pull down, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhang Y (1998), Zhang Y (1998), Zhang Y (1999), Kuzmichev A (2002), Lai A (2001), Zhang Y (1998), Zhang Y (1998), Hauri S (2016)	8