PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
TRAF2	1	UBC	7	enzymatic study, enzymatic study	Liu J (2011), Kanayama A (2004)	2
RUNX2	2	HIVEP3	12	affinity chromatography technology, pull down	Jones DC (2006), Jones DC (2006)	2
HNRNPL	3	WWP1	3	affinity chromatography technology	Fei T (2017)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
HIVEP3	12	TRAF2	1	two hybrid, affinity chromatography technology	Oukka M (2002), Oukka M (2002)	2
FUS	0	HIVEP3	12	affinity chromatography technology	Wang T (2014)	1
RUNX2	2	WWP1	3	affinity chromatography technology, affinity chromatography technology	Jones DC (2006), Jones DC (2006)	2
FHL1	1	HIVEP3	12	affinity chromatography technology, two hybrid, pull down	Qin H (2004), Qin H (2004), Qin H (2004)	3
HIVEP3	12	TRAF1	0	two hybrid, affinity chromatography technology	Oukka M (2002), Oukka M (2002)	2
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
NUP35	0	HIVEP3	12	bioid	Kim DI (2014)	1
FUS	0	UBC	7	affinity chromatography technology	Wang T (2014)	1
TRAF1	0	UBC	7	affinity chromatography technology	Greenfeld H (2015)	1
FUS	0	HNRNPL	3	affinity chromatography technology, biochemical	Wang T (2014), Wan C (2015)	2
HNRNPL	3	HIVEP3	12	affinity chromatography technology	Fei T (2017)	1
UBC	7	FHL1	1	affinity chromatography technology	Matsumoto M (2005)	1
WWP1	3	UBC	7	enzymatic study	Kristariyanto YA (2015)	1
HIVEP3	12	WWP1	3	affinity chromatography technology	Jones DC (2006)	1
TRAF1	0	TRAF2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, imaging technique, affinity chromatography technology, affinity chromatography technology	Bouwmeester T (2004), Takeuchi M (1996), Li S (2011), Li S (2011), Fries KL (1999), He L (2004), Zheng C (2010), Zheng C (2010), Relaix F (1998), Relaix F (1998), Jang HD (2001), Fotin-Mleczek M (2004), Pullen SS (1998), Wicovsky A (2009), Rothe M (1994), Rothe M (1994), Chen TC (2014), Greenfeld H (2015), Huttlin EL (2017)	19
UBC	7	HIVEP3	12	affinity chromatography technology	Matsumoto M (2005)	1
TRIM25	5	FUS	0	affinity chromatography technology, affinity chromatography technology	Choudhury NR (2017), Choudhury NR (2017)	2
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
TRIM25	5	HIVEP3	12	affinity chromatography technology	Choudhury NR (2017)	1