Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
ACE2 59272 LISINOPRIL CHEMBL1237 inhibitor TdgClinicalTrial, DrugBank 11752352, 1536695, 11929321, 11030016
ACE2 59272 CHEMBL429844 CHEMBL429844 inhibitor GuideToPharmacologyInteractions
ACE2 59272 CHEMBL260273 CHEMBL260273 inhibitor GuideToPharmacologyInteractions
ACE2 59272 FLUTAMIDE CHEMBL806 GuideToPharmacologyInteractions

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
ACE2 rs2106809 GG atenolol efficacy no There was no significant change in systolic or diastolic blood pressure between genotypes after 4 weeks of treatment. Please note alleles have been complemented to the plus chromosomal strand. Genotype GG is not associated with response to atenolol in women with Hypertension as compared to genotypes AA + AG. 17473847 982037542
ACE2 rs2106809 GG hydrochlorothiazide efficacy no There was no significant change in systolic or diastolic blood pressure between genotypes after 4 weeks of treatment. Please note alleles have been complemented to the plus chromosomal strand. Genotype GG is not associated with response to hydrochlorothiazide in women with Hypertension as compared to genotypes AA + AG. 17473847 982037550
ACE2 rs2106809 GG captopril efficacy no There was no significant change in systolic blood pressure between genotypes after 4 weeks of treatment. Please note alleles have been complemented to the plus chromosomal strand. Genotype GG is not associated with response to captopril in women with Hypertension as compared to genotypes AA + AG. 17473847 982037525
ACE2 rs2106809 GG captopril efficacy yes GG homozygotes had a significantly greater decrease in diastolic blood pressure after 4 weeks of treatment, as compared to A allele carriers. Please note alleles have been complemented to the plus chromosomal strand. Genotype GG is associated with increased response to captopril in women with Hypertension as compared to genotypes AA + AG. 17473847 982037510
ACE2 rs2106809 GG nifedipine efficacy no There was no significant change in systolic or diastolic blood pressure between genotypes after 4 weeks of treatment. Please note alleles have been complemented to the plus chromosomal strand. Genotype GG is not associated with response to nifedipine in women with Hypertension as compared to genotypes AA + AG. 17473847 982037533