PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
SRC	2	FYN	1	unspecified method, affinity chromatography technology, affinity chromatography technology	Pirozzi G (1997), Chen Y (2009), Huttlin EL (2017)	3
LYN	2	TRPV4	2	enzymatic study, affinity chromatography technology	Xu H (2003), Xu H (2003)	2
TRPV4	2	KRIT1	1	unspecified method	Strotmann R (2003)	1
YES1	1	FYN	1	affinity chromatography technology, affinity chromatography technology	Piedra J (2003), Huttlin EL (2017)	2
ITCH	1	TRPV4	2	affinity chromatography technology	Shukla AK (2010)	1
ARRB2	5	ITCH	1	affinity chromatography technology, affinity chromatography technology, pull down	Shenoy SK (2008), Bhandari D (2007), Bhandari D (2007)	3
ARRB2	5	TRPV4	2	affinity chromatography technology	Xiao K (2007)	1
TRPV4	2	LCK	0	affinity chromatography technology	Xu H (2003)	1
ARRB2	5	SRC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Rosano L (2009), Luan B (2009), Kim YM (2002), Lee J (2013)	4
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
OS9	4	TRPV4	2	affinity chromatography technology, affinity chromatography technology	Wang Y (2007), Wang Y (2007)	2
MAP7	3	TRPV4	2	pull down, affinity chromatography technology, two hybrid	Suzuki M (2003), Suzuki M (2003), Suzuki M (2003)	3
TRPV4	2	SRC	2	affinity chromatography technology	Xu H (2003)	1
HCK	5	SRC	2	affinity chromatography technology	Howlett CJ (2002)	1
TRPV4	2	HCK	5	affinity chromatography technology	Xu H (2003)	1
ITCH	1	FYN	1	affinity chromatography technology, affinity chromatography technology, pull down	Yang C (2006), Yang C (2006), Yang C (2006)	3
TRPV4	2	FYN	1	affinity chromatography technology	Xu H (2003)	1
TRPV4	2	YES1	1	affinity chromatography technology	Xu H (2003)	1
TRPV4	2	AKAP5	0	affinity chromatography technology, affinity chromatography technology	Zhang X (2008), Zhang X (2008)	2