PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
BIK	0	APP	1	pull down	Olah J (2011)	1
BCL2A1	0	BIK	0	unspecified method, two hybrid	Chen L (2005), Rolland T (2014)	2
BAD	1	BAX	3	affinity chromatography technology	Flores-Delgado G (2007)	1
BID	1	BAK1	0	unspecified method	Holloway A (2014)	1
BCL2A1	0	APP	1	pull down	Olah J (2011)	1
BCL2A1	0	NR4A1	4	affinity chromatography technology	Kolluri SK (2008)	1
BID	1	BAX	3	imaging technique	Chen TC (2014)	1
BAK1	0	BAX	3	affinity chromatography technology, affinity chromatography technology	Sundararajan R (2001), Gogada R (2011)	2
BOK	1	BCL2A1	0	two hybrid	Hsu SY (1997)	1
PMAIP1	0	BAX	3	affinity chromatography technology	Sun Y (2005)	1
BAK1	0	BCL2A1	0	two hybrid	Rolland T (2014)	1
BCL2L11	4	APP	1	pull down	Olah J (2011)	1
BID	1	BCL2A1	0	affinity chromatography technology, unspecified method	Werner AB (2002), Certo M (2006)	2
BCL2A1	0	HRK	0	unspecified method	Chen L (2005)	1
BCL2L11	4	BCL2A1	0	two hybrid, unspecified method	Hsu SY (1998), Certo M (2006)	2
BCL2A1	0	BMF	0	unspecified method	Chen L (2005)	1
HAT1	0	BCL2A1	0	x-ray crystallography	Wu H (2012)	1
BAX	3	BCL2A1	0	two hybrid, pull down	Zhang H (2000), Zhang H (2000)	2
BCL2A1	0	FAM9B	0	two hybrid	Rolland T (2014)	1
BCL2A1	0	BAD	1	two hybrid, unspecified method, pull down	Bae J (2001), Chen L (2005), Bae J (2001)	3
BCL2A1	0	BBC3	1	unspecified method	Certo M (2006)	1
BCL2A1	0	PMAIP1	0	unspecified method	Chen L (2005)	1
BCL2L11	4	BAX	3	affinity chromatography technology	Huttlin EL (2015)	1