PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
EIF4E	1	TRIM27	2	two hybrid, two hybrid	Corominas R (2014), Rolland T (2014)	2
TRIM27	2	PPP1R18	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
LNX1	7	CPNE2	2	two hybrid	Rolland T (2014)	1
MBD4	1	TRIM27	2	affinity chromatography technology, affinity chromatography technology, pull down, pull down, two hybrid	Fukushige S (2006), Fukushige S (2006), Fukushige S (2006), Fukushige S (2006), Yu H (2011)	5
PIAS3	2	TRIM32	2	pull down	Qu J (2007)	1
UBE2N	1	TRIM27	2	two hybrid, affinity chromatography technology	Napolitano LM (2011), Napolitano LM (2011)	2
ZNF219	3	MBD2	1	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
MBD2	1	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Brackertz M (2002), Ng HH (1999), Ng HH (1999), Ng HH (1999), Zhang Y (1999), Zhang Y (1999), Feng Q (2001), Humphrey GW (2001), Humphrey GW (2001), Godmann M (2007), Bantscheff M (2011), Joshi P (2013), Fujita H (2003), Hein MY (2015), Huttlin EL (2017), Boldt K (2016)	16
TRIM23	3	UBE2D1	0	pull down, pull down	Vichi A (2005), Vichi A (2006)	2
TRIM27	2	FBF1	2	two hybrid, two hybrid	Rual JF (2005), Rolland T (2014)	2
NDE1	2	TRIM27	2	two hybrid, affinity chromatography technology, affinity chromatography technology	Corominas R (2014), Huttlin EL (2015), Huttlin EL (2017)	3
USP7	14	RB1	2	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Bhattacharya S (2014), Bhattacharya S (2014), Bhattacharya S (2014), Bhattacharya S (2014)	4
ZNF219	3	MBD3	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
UBE2D3	1	TRIM27	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
TRIM32	2	UBE2D1	0	affinity chromatography technology, pull down, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Albor A (2006), Mokhonova EI (2015)	5
TRIM27	2	CDC23	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TBK1	1	IKBKE	2	affinity chromatography technology, pull down, affinity chromatography technology, pull down	Li S (2011), Ikeda F (2007), Liu D (2015), Liu D (2015)	4
TRIM23	3	JOSD1	1	two hybrid	Rolland T (2014)	1
CDC23	3	NFYC	0	genetic interference	Horlbeck MA (2018)	1
TRIM27	2	TBK1	1	affinity chromatography technology, enzymatic study	Zha J (2006), Zha J (2006)	2
MBD3	4	MBD2	1	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, two hybrid, two hybrid, pull down, affinity chromatography technology	Jiang CL (2004), Zhang Y (1999), Tatematsu KI (2000), Tatematsu KI (2000), Tatematsu KI (2000), Tatematsu KI (2000), Jin SG (2005), Jin SG (2005), Jin SG (2005), Feng Q (2001)	10
TRIM27	2	IKBKE	2	affinity chromatography technology, enzymatic study	Zha J (2006), Zha J (2006)	2
TRIM27	2	PIAS2	2	affinity chromatography technology, two hybrid	Matsuura T (2005), Matsuura T (2005)	2
USP2	0	TRIM27	2	two hybrid, two hybrid	Hayes SD (2012), Rolland T (2014)	2
MBD3	4	CHD4	22	affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology	Sakai H (2002), Cui S (2011), Havugimana PC (2012), Quan J (2014)	4
TRIM27	2	PIAS4	5	affinity chromatography technology, two hybrid	Matsuura T (2005), Matsuura T (2005)	2
MDM2	2	UBE2N	1	pull down	David Y (2011)	1
LNX1	7	JOSD1	1	two hybrid	Guo Z (2012)	1
TRIM27	2	RB1	2	two hybrid, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology	Kruetzfeldt M (2005), Kruetzfeldt M (2005), Kruetzfeldt M (2005), Kruetzfeldt M (2005), Kruetzfeldt M (2005)	5
UBE2I	0	RB1	2	enzymatic study, pull down	Ledl A (2005), Ledl A (2005)	2
PIAS1	4	CHUK	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Liu B (2007), Lau R (2012), Lau R (2012)	3
TRIM27	2	PIAS1	4	two hybrid, affinity chromatography technology	Matsuura T (2005), Matsuura T (2005)	2
UBE2D1	0	TRIM27	2	two hybrid, two hybrid, two hybrid, affinity chromatography technology	Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011)	4
UBE2I	0	HDAC1	4	enzymatic study	Citro S (2013)	1
LNX1	7	UBE2D2	0	pull down, pull down, pull down	Nie J (2002), Nie J (2004), Guo Z (2012)	3
TRIM29	2	TRIM23	3	two hybrid, two hybrid, two hybrid	Reymond A (2001), Reymond A (2001), Rolland T (2014)	3
UBE2I	0	UBE2E1	1	biochemical	Wan C (2015)	1
TP53	0	CHUK	5	affinity chromatography technology	Huang WC (2007)	1
PIAS2	2	PIAS1	4	imaging technique	Chen TC (2014)	1
TRIM32	2	TP53	0	affinity chromatography technology, affinity chromatography technology	Liu J (2014), Liu J (2014)	2
TRIM27	2	CHD4	22	two hybrid, affinity chromatography technology	Shimono Y (2003), Shimono Y (2003)	2
MBD4	1	USP7	14	affinity chromatography technology, affinity chromatography technology	Meng H (2014), Meng H (2014)	2
EIF3E	1	TRIM27	2	affinity chromatography technology, two hybrid	Morris-Desbois C (1999), Morris-Desbois C (1999)	2
MDM2	2	USP2	0	two hybrid, pull down, affinity chromatography technology, pull down	Stevenson LF (2007), Stevenson LF (2007), Stevenson LF (2007), Stevenson LF (2007)	4
TP53	0	PIAS4	5	two hybrid	Goehler H (2004)	1
MDM2	2	TP53	0	enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, biochemical, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, pull down, protein complementation assay, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, two hybrid, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, pull down, pull down, unspecified method, affinity chromatography technology, two hybrid, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, protein complementation assay, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, far western blotting, affinity chromatography technology, x-ray crystallography, unspecified method, pull down, pull down, pull down, unspecified method, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, genetic interference, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, biochemical, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, two hybrid, pull down, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, enzymatic study, enzymatic study, pull down, enzymatic study, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, protein complementation assay, imaging technique, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, pull down, affinity chromatography technology, pull down, enzymatic study, enzymatic study, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, x-ray crystallography, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, enzymatic study, affinity chromatography technology, enzymatic study, affinity chromatography technology, pull down, pull down, unspecified method, affinity chromatography technology, imaging technique, enzymatic study, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, enzymatic study, pull down, pull down, unspecified method, fluorescent resonance energy transfe, two hybrid, pull down	Li M (2003), Latonen L (2001), Zhang Y (2003), Zhang Y (2003), Kurki S (2003), Kurki S (2003), Freeman DJ (2003), Ito A (2002), Ito A (2002), Grossman SR (1998), Fang S (2000), Liu G (2000), Zhang Y (1998), Zhang Y (1998), Chen J (1993), Thut CJ (1997), Leung KM (2002), Wawrzynow B (2009), Ochocka AM (2009), Chen D (2009), Hedstroem E (2009), Brenkman AB (2008), Qiu W (2008), Qiu W (2008), Zhang Z (2008), Muller P (2008), Colaluca IN (2008), Colaluca IN (2008), Colaluca IN (2008), Tang Y (2008), Tang Y (2008), Lu X (2007), Lukashchuk N (2007), Lukashchuk N (2007), Lee JH (2007), Carter S (2007), Sasaki M (2007), Brooks CL (2007), Li L (2007), Becker K (2007), Zhao BX (2006), Zhao BX (2006), Abida WM (2007), Yang WH (2006), Ma J (2006), Wallace M (2006), Shimizu H (2006), Andrews P (2006), Yang J (2009), Zhu Z (2009), Wang C (2005), Higashitsuji H (2005), Higashitsuji H (2005), Yan C (2005), Vega FM (2004), Dai MS (2004), Dai MS (2004), Groenroos E (2004), Ohkubo S (2006), Sui G (2004), Di Stefano V (2004), Brignone C (2004), Katayama H (2004), Linares LK (2003), OKeefe K (2003), Wang W (2003), Blattner C (2002), Matt T (2004), Matt T (2004), Eyckerman S (2005), Shimizu H (2002), Shimizu H (2002), Migliorini D (2002), Gu J (2001), Sengupta S (2001), Chernov MV (2001), Cross B (2011), Cross B (2011), Cross B (2011), Buschmann T (2001), Nakamura S (2000), Rodriguez MS (2000), Rodriguez MS (2000), Geyer RK (2000), Zaika A (1999), Maki CG (1999), Chen L (2010), Chen L (2010), Lin RK (2010), Fuchs SY (1998), Xirodimas DP (2001), Fuchs SY (1998), Inoue T (2001), Wu L (2011), Du W (2009), Li DQ (2009), Illuzzi JL (2011), Oliver TG (2011), Kim MM (2007), Marchenko ND (2007), Vaseva AV (2009), Vaseva AV (2009), Lai KP (2010), Naderi EH (2011), Zdzalik M (2010), Singh RK (2007), Meng L (2011), Moore L (2007), Kim S (2010), Inoue Y (2011), Fraser JA (2010), Worrall EG (2009), Wu H (2011), Wang KS (2011), Wang KS (2011), Wang KS (2011), Izumi T (2010), Huang YF (2009), Tang J (2006), Tang J (2006), Fu X (2010), Fu X (2010), Shloush J (2011), Yadavilli S (2009), Stevenson LF (2007), Suzuki T (2010), Cheng Q (2009), Kulikov R (2010), Kulikov R (2010), Li L (2010), Li L (2010), Cheng Q (2011), Li D (2011), Nie J (2010), Demma M (2010), Sun XX (2011), Jung CR (2010), Jung CR (2010), Jung CR (2010), Jung CR (2010), Nishida T (2011), Li M (2011), Li M (2011), Amson R (2011), Amson R (2011), Bhatt P (2011), David Y (2011), Zhang Y (2010), Liu J (2010), Liu J (2010), Song MS (2008), Cummins JM (2004), Kim CK (2010), Kim CK (2010), Yan C (2010), Wang X (2011), Phillips A (2010), Phillips A (2010), Kang HN (2011), Kang HN (2011), Wang X (2004), Sionov RV (2001), Wei S (2012), Camus S (2012), Ding B (2012), Yang Z (2012), Yang Z (2012), Tripathi V (2007), Tripathi V (2007), Dai C (2011), Chen S (2012), Honda R (1997), Kinyamu HK (2003), Zhan C (2012), Zhan C (2012), Lee CW (2010), Zhou X (2012), Bouska A (2008), Wade M (2012), Ferreon JC (2009), Domenici F (2011), Uldrijan S (2007), Uldrijan S (2007), Stad R (2000), Stad R (2000), Banks D (2006), Banks D (2006), Bernal F (2010), Bernal F (2010), Jain AK (2012), Kane SA (2000), Tan Z (2000), Yang Z (2012), Wawrzynow B (2007), Wawrzynow B (2007), Wawrzynow B (2007), Hiramatsu K (2006), Bao-Lei T (2006), Kulikov R (2005), Yang Y (2005), Lindstroem MS (2007), Bech-Otschir D (2001), Li Y (2012), Gillotin S (2010), Burch L (2004), Liu WL (2001), OHagan HM (2004), OHagan HM (2004), Funari G (2009), Candeias MM (2008), Brew CT (2006), Wang J (2011), Calabro V (2002), Burch L (2004), Iyappan S (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Poyurovsky MV (2010), Kurki S (2004), Tian LF (2006), Wang J (2006), Bae S (2012), Bae S (2012), Frazier DP (2012), Frazier DP (2012), Lew QJ (2012), Lew QJ (2012), Huart AS (2012), Li Z (2004), Balint E (1999), Balint E (1999), Funston G (2012), Dou X (2012), Sadagopan S (2012), Sadagopan S (2012), Dixit D (2012), Roxburgh P (2012), Xu L (2012), Drago-Ferrante R (2008), Li H (2009), Negorev D (2001), Wang X (2012), Wang X (2012), Wang X (2012), Boettger A (1997), Jung H (2008), Oliner JD (1992), Seemann S (2005), Kawai H (2007), Schuster K (2007), Dawson R (2003), DArcy P (2009), Schon O (2004), Schon O (2004), Hogan C (2008), Lottin-Divoux S (2005), Latini P (2011), Latini P (2011), Latini P (2011), McCoy MA (2003), Kussie PH (1996), Shieh SY (1997), Shieh SY (1997), Naski N (2009), Naski N (2009), Schon O (2002), Tamborini E (2001), Wade M (2006), Wade M (2006), Lohrum MA (2003), Garcia JF (2002), Garcia JF (2002), Kallen J (2009), Kulikov R (2006), Kulikov R (2006), Czarna A (2009), Czarna A (2009), Hu B (2007), Chi SW (2005), Yu GW (2006), Yu GW (2006), Saji S (2001), Chen L (1997), Zhang H (1998), Issaeva N (2004), Wade M (2008), Wade M (2008), Chen HF (2007), Chen HF (2007), Li HH (2004), Wang J (2011), Gu L (2009), Gu L (2009), Meng L (2008), Meng L (2008), Okamoto K (2006), Malaguarnera R (2008), Zhou M (2003), Zhou M (2003), Di Conza G (2012), Xirodimas DP (2004), Auger KR (2005), Li J (2011), Li J (2011), Li J (2011), Lee SJ (2007), Chau JF (2012), Lu X (2005), Mazars A (2010), Mazars A (2010), Mazars A (2010), Olson DC (1993), Picksley SM (1994), Issaeva N (2004), Issaeva N (2004), Zhang J (2012), Wen W (2013), Wen W (2013), Bursac S (2012), Yang Y (2013), Yang Y (2013), Landre V (2013), Pettersson S (2012), Thin TH (2007), Thin TH (2007), Piccinin S (2012), Shan B (2012), Caratozzolo MF (2012), Lui K (2013), Kobet E (2000), Lim KH (2010), Ranaweera RS (2013), Cui D (2013), Ebina M (2013), He Y (2013), He Y (2013), Siepe D (2009), Suh HW (2013), Zhan YA (2013), Wang J (2011), Hjerpe R (2010), Murray MF (2007), Jin L (2013), Jin L (2013), Zhang R (2013), Yan S (2013), Sun XX (2011), Heyne K (2014), Heyne K (2014), Bista M (2013), Jin J (2014), Mikawa T (2014), Qi M (2014), Cheng Q (2014), Zhang HH (2014), Perry ME (2000), Nishizaki M (2004), Sanchez-Aguilera A (2006), Chen YC (2013), Bertamino A (2013), Ding G (2013), Kubo N (2013), Kubo N (2013), Hsueh KW (2013), Kofod-Olsen E (2014), Fogeron ML (2013), Chang YS (2013), Gotoh T (2014), Gotoh T (2014), Oi N (2014), Corcoran CA (2009), Corcoran CA (2009), Ayroldi E (2014), Wu G (2014), Rajendra R (2004), Zhang J (2014), Lee MG (2014), Lee MG (2014), Freedman DA (1997), Freedman DA (1997), Saxena A (2006), Shi D (2009), Lohrum MA (2001), Lohrum MA (2001), Grossman SR (2003), Yan S (2013), Xirodimas DP (2004), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Yasuhara T (2014), Saville MK (2004), Rodriguez MS (1999), Lui K (2013), Wu PY (2003), Pavithra L (2009), He Y (2013), Tan BX (2014), Huttlin EL (2015), Marcar L (2015), Borcherds W (2014), Borcherds W (2014), Li YC (2014), Ayroldi E (2014), Ling X (2014), Batuello CN (2015), Zhu N (2006), Mo XL (2015), Chen TC (2014), Stindt MH (2015), Caratozzolo MF (2014), Li X (2015), Saxena R (2016), Reed SM (2014), Du C (2016), Du C (2016), Du C (2016), Fraser JA (2015), Fraser JA (2015), Wu B (2015), Qin JJ (2015), Raza S (2015), Raza S (2015), Yamauchi T (2014), Yamauchi T (2014), Yamauchi T (2014), Shi Y (2010), Ahn HJ (2015), Lim KH (2015), Kang JH (2016), Chen J (2015), Liu X (2016), Yang P (2016), Yang P (2016), Liu D (2016), Liu D (2016), Liu D (2016), Datta D (2015), Reddy BA (2014), He X (2016), Shostak K (2014), Liu LJ (2016), Liu LJ (2016), Stegh AH (2010), Liu XH (2005), Medina-Medina I (2016), Medina-Medina I (2016), Kayama K (2017), Singh AK (2016), Liu WT (2016), Yue X (2016), Soares J (2015), Mukhopadhyay R (2016), Mukhopadhyay R (2016), Zhou X (2016), Zhou X (2016), Xie X (2016), Leao M (2015), Luo H (2016), Luo H (2016), Xie N (2016), Maeda R (2017), Maeda R (2017), Maeda R (2017), Sheng W (2017), Sheng W (2017), Liu M (2010), Huttlin EL (2017), Chauhan KM (2016), Goetz C (1999), Zhang J (2017), Unger T (1999), Liu Z (2004), Wu W (2015), Tan G (2017), Nomura K (2017), Lu W (2017), Lu W (2017), Hjerrild M (2001), Landre V (2017), Landre V (2017), Landre V (2017), Landre V (2017), Shangary S (2008), Shangary S (2008), Du WW (2017), Du WW (2017), Bista M (2013), Bista M (2013), Jin M (2017), LaRusch GA (2007), LaRusch GA (2007), Kurokawa M (2013), Ivanov AA (2017), Wong JH (2017), Wong JH (2017)	496
TP53	0	PIAS2	2	pull down, pull down, two hybrid, enzymatic study, enzymatic study, imaging technique	Schmidt D (2002), Schmidt D (2002), Wang J (2008), Wu SY (2009), Schmidt D (2002), Chen TC (2014)	6
UBE2I	0	CHUK	5	enzymatic study	Bernier-Villamor V (2002)	1
UBE2I	0	PIAS3	2	two hybrid, two hybrid	Bandyopadhyay S (2010), Wang J (2011)	2
TRIM23	3	UBE2N	1	pull down	Dawidziak DM (2017)	1
TRIM27	2	MDM2	2	affinity chromatography technology, enzymatic study	Chu Y (2011), Chu Y (2011)	2
UBE2I	0	TRIM29	2	two hybrid	Rual JF (2005)	1
TP53	0	USP7	14	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, unspecified method, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Li M (2002), Li M (2002), Li M (2002), Li M (2002), Brooks CL (2007), Brooks CL (2007), Becker K (2007), Hu M (2006), Hu M (2006), Sarkari F (2010), Marchenko ND (2007), Epping MT (2011), Qing P (2011), Tang J (2006), Ma J (2010), Dai C (2011), Holowaty MN (2003), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Yi P (2013), Yi P (2013), Zhang J (2014), Fang Z (2013), Ye M (2015), Lim KH (2015), Lim KH (2015), Reddy BA (2014), Reddy BA (2014)	29
HDAC1	4	TRIM27	2	imaging technique, affinity chromatography technology	Kato T (2009), Shimono Y (2003)	2
TRIM23	3	UBE2E1	1	pull down, pull down, pull down, enzymatic study, pull down	Ko JA (2006), Vichi A (2005), Vichi A (2006), Vichi A (2005), Dawidziak DM (2017)	5
UBE2D4	0	TRIM27	2	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
TRIM27	2	PIAS3	2	affinity chromatography technology, two hybrid	Matsuura T (2005), Matsuura T (2005)	2
UBE2I	0	MDM2	2	pull down, affinity chromatography technology, enzymatic study, unspecified method	Buschmann T (2001), Buschmann T (2001), Buschmann T (2001), Buschmann T (2001)	4
MBD2	1	TRIM27	2	affinity chromatography technology, affinity chromatography technology	Fukushige S (2006), Fukushige S (2006)	2
RB1	2	HDAC1	4	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Dick FA (2000), Fuks F (2000), Puri PL (2001), Puri PL (2001), Wang S (2002), Luo RX (1998), Luo RX (1998), Lai A (1999), Lai A (1999), Ferreira R (1998), Kimura H (2003), Qiu Z (2008), Fedele M (2006), Brown VD (2002), Khan MM (2001), Dasgupta P (2004), Chang YC (2001), Dahiya A (2000), Zhang HS (2000), Tokitou F (1999), Nguyen DX (2004), Takaki T (2004), Magnaghi-Jaulin L (1998), Magnaghi-Jaulin L (1998), Brehm A (1998), Brehm A (1998), Brehm A (1998), Sun JM (2007), Fan LX (2012), Harbour JW (1999), Brehm A (1999), Joshi P (2013), Chen TT (2000), Chen TT (2000), Chen TT (2000), Chen TT (2000)	36
TRIM29	2	FBF1	2	two hybrid	Rual JF (2005)	1
NDEL1	2	ZNF417	2	two hybrid	Rolland T (2014)	1
TRIM23	3	UBE2D2	0	pull down, pull down, pull down	Vichi A (2005), Vichi A (2006), Dawidziak DM (2017)	3
UBE2D2	0	TRIM27	2	two hybrid, two hybrid	Markson G (2009), Napolitano LM (2011)	2
TRIM27	2	TUFT1	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
MDM2	2	TRIM23	3	two hybrid	Woodsmith J (2012)	1
TRIM23	3	ZC2HC1C	0	two hybrid	Rolland T (2014)	1
MDM2	2	UBE2E3	0	pull down, pull down	David Y (2011), Yamauchi T (2014)	2
TRIM32	2	UBE2D3	1	affinity chromatography technology, pull down, pull down, pull down	Napolitano LM (2011), Zhang J (2012), Streich FC (2013), Mokhonova EI (2015)	4
USP7	14	UBE2D3	1	enzymatic study	Zhang ZM (2015)	1
MAGEL2	6	USP7	14	affinity chromatography technology, bioid	Hao YH (2013), Wijesuriya TM (2017)	2
TRIM32	2	TRIM27	2	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
ZNF219	3	HDAC1	4	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TP53	0	PRAM1	4	affinity chromatography technology	Insinga A (2004)	1
TP53	0	UBE2N	1	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study	Laine A (2006), Laine A (2006), Laine A (2006), Topisirovic I (2009), Topisirovic I (2009)	5
EPC1	2	TRIM27	2	two hybrid, two hybrid	Shimono Y (2000), Shimono Y (2000)	2
MBD3	4	TRIM27	2	affinity chromatography technology, affinity chromatography technology	Fukushige S (2006), Fukushige S (2006)	2
MBD4	1	HDAC1	4	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid	Kondo E (2005), Kondo E (2005), Kondo E (2005), Kondo E (2005), Kondo E (2005)	5
NDE1	2	NDEL1	2	two hybrid, affinity chromatography technology	Corominas R (2014), Huttlin EL (2017)	2
USP7	14	MDM2	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, unspecified method, unspecified method, biochemical, x-ray crystallography, pull down, unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, x-ray crystallography, unspecified method, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Lu X (2007), Becker K (2007), Pereg Y (2006), Hu M (2006), Hu M (2006), Hu M (2006), Hu M (2006), Sarkari F (2010), Sarkari F (2010), Tang J (2006), Tang J (2006), Ma J (2010), Song MS (2008), Sheng Y (2006), Sheng Y (2006), Sheng Y (2006), Ye M (2015), Lim KH (2015), Reddy BA (2014), Rouge L (2016), Nihira NT (2017), Nihira NT (2017), Mungamuri SK (2016), Mungamuri SK (2016), Sun Y (2017)	25
TRIM27	2	UBE2E3	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
TRIM23	3	FBF1	2	two hybrid	Rolland T (2014)	1
TRIM27	2	ZNF417	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
UBE2I	0	TRIM23	3	two hybrid, two hybrid, two hybrid	Markson G (2009), Rolland T (2014), Yu H (2011)	3
PIAS2	2	PIAS4	5	two hybrid	Wang J (2011)	1
PIAS1	4	MDM2	2	enzymatic study	Miyauchi Y (2002)	1
MDM2	2	UBE2D3	1	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Yadavilli S (2009), Nie J (2010), Minsky N (2004), Wang X (2011), Sionov RV (2001), Oh W (2010), Zhu Y (2009), Latini P (2011), Jung CR (2010), David Y (2011), Ye B (2013), Cheng Q (2014), Saville MK (2004), Yamauchi T (2014), Jin M (2017)	15
RB1	2	TP53	0	affinity chromatography technology, pull down	Delston RB (2011), Sommer MH (1994)	2
TRIM29	2	TRIM27	2	two hybrid, affinity chromatography technology	Reymond A (2001), Hein MY (2015)	2
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
TRIM23	3	LNX1	7	two hybrid	Rual JF (2005)	1
TRIM27	2	TRIM23	3	two hybrid, two hybrid	Reymond A (2001), Woodsmith J (2012)	2
HDAC1	4	MDM2	2	affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Ito A (2002), Ito A (2002), Gaughan L (2005), Gaughan L (2005)	5
LNX1	7	NDEL1	2	affinity chromatography technology	Lenihan JA (2017)	1
TRIM23	3	PPP1R18	2	two hybrid	Rolland T (2014)	1
UBE2D1	0	MDM2	2	two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Singh RK (2007), Poyurovsky MV (2007), Li M (2003), Yogosawa S (2003), Honda R (1997), Sun XX (2011), Singh RK (2007), Taira N (2010), Fu X (2010), Wang KS (2011), Wang X (2004), Sehat B (2008), Wawrzynow B (2007), Burch L (2004), Frazier DP (2012), Huart AS (2012), Pettersson S (2009), Gama V (2009), Demma M (2010), Chymkowitch P (2011), Yan C (2010), Yang Y (2013), Ranaweera RS (2013), Siepe D (2009), Shi D (2009), Uchiki T (2009), Grossman SR (2003), Xirodimas DP (2004), Saville MK (2004), Liu T (2015), Batuello CN (2015), Fraser JA (2015), Yamauchi T (2014), Liu D (2016), McClurg UL (2016), Landre V (2017)	36
TRIM27	2	IKBKB	1	affinity chromatography technology, enzymatic study	Zha J (2006), Zha J (2006)	2
TRIM27	2	NFYC	0	imaging technique, affinity chromatography technology	Kato T (2009), Kato T (2009)	2
RB1	2	MDM2	2	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down	Hsieh JK (1999), Nguyen DX (2004), Zheng Z (2012), Sdek P (2005), Delston RB (2011), Delston RB (2011), Sdek P (2004), Sdek P (2004), Xiao ZX (1995), Xiao ZX (1995), Xiao ZX (1995), Uchida C (2006), Markham D (2006), Chan HM (2001), Chan HM (2001), Zhang H (2015), Zhang H (2015), Jaenicke RU (1996)	18
TRIM27	2	CPNE2	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PIK3C2B	5	TRIM27	2	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique	Cai X (2011), Cai X (2011), Cai X (2011), Cai X (2011)	4
TRIM27	2	PAX7	3	affinity chromatography technology, affinity chromatography technology	Joung H (2014), Joung H (2014)	2
TRIM27	2	NDEL1	2	two hybrid, affinity chromatography technology	Rolland T (2014), Huttlin EL (2017)	2
USP2	0	TRIM23	3	two hybrid	Hayes SD (2012)	1
TRIM27	2	JOSD1	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
HDAC1	4	CHD4	22	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Yao YL (2003), Yao YL (2003), Grozinger CM (1999), Tong JK (1998), Tong JK (1998), Humphrey GW (2001), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Zhang Y (1998), Terhune SS (2010), Polo SE (2010), Xue Y (1998), Xue Y (1998), Xue Y (1998), Kwintkiewicz J (2011), Cui S (2011), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Quan J (2014), Wan C (2015), Hein MY (2015), Weiss K (2016), Huttlin EL (2017)	28
TRIM27	2	FNDC11	3	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
PIAS4	5	UBE2I	0	two hybrid, pull down, pull down, pull down	Wang J (2011), Yamamoto H (2003), Yin Y (2012), Ryu H (2010)	4
MBD3	4	HDAC1	4	affinity chromatography technology, biochemical, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology	Sakai H (2002), Zhang Y (1999), Zhang Y (1999), Saito M (2002), Noh EJ (2009), Noh EJ (2009), Le Guezennec X (2006), Humphrey GW (2001), Sun JM (2007), Cui S (2011), Havugimana PC (2012), Bantscheff M (2011), Joshi P (2013), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	16
IKBKB	1	TP53	0	enzymatic study	Xia Y (2009)	1
TRIM32	2	UBE2D2	0	affinity chromatography technology, pull down, pull down	Napolitano LM (2011), Streich FC (2013), Mokhonova EI (2015)	3
USP2	0	NDEL1	2	two hybrid	Rolland T (2014)	1
NFYC	0	HDAC1	4	affinity chromatography technology	Kato T (2009)	1
TP53	0	HDAC1	4	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, imaging technique, affinity chromatography technology, affinity chromatography technology, imaging technique	Ito A (2002), Wang C (2005), Dohi Y (2008), Jin W (2008), Lei Q (2006), Wu Y (2001), Wu Y (2001), Luo J (2000), Juan LJ (2000), Juan LJ (2000), Juan LJ (2000), Murphy M (1999), Insinga A (2004), Sun JM (2007), Yu XY (2010), Sinha S (2010), Sinha S (2010), Li Y (2012), Di Agostino S (2006), Pavithra L (2009), Pavithra L (2009), Luo J (2000), Chen TC (2014), Park EK (2015), Park EK (2015), Park EK (2015)	26
LNX1	7	TRIM27	2	affinity chromatography technology, affinity chromatography technology	Lenihan JA (2017), Lenihan JA (2017)	2
TRIM29	2	UBE2E1	1	pull down	Xing J (2016)	1
UBE2I	0	PIAS2	2	two hybrid, two hybrid, two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down	Rual JF (2005), Lee BH (2003), Bandyopadhyay S (2010), Schmidt D (2002), Wang J (2011), Rolland T (2014), Saul VV (2014), van den Akker E (2005), Schmidt D (2002)	9
TRIM27	2	TP53	0	affinity chromatography technology, pull down, enzymatic study	Chu Y (2011), Chu Y (2011), Chu Y (2011)	3
TRIM23	3	PIAS2	2	two hybrid	Rolland T (2014)	1
TRIM23	3	UBE2D3	1	pull down, pull down, pull down	Vichi A (2005), Vichi A (2006), Dawidziak DM (2017)	3
TRIM23	3	TBK1	1	affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Sparrer KMJ (2017), Sparrer KMJ (2017), Sparrer KMJ (2017), Sparrer KMJ (2017)	4
IKBKB	1	IKBKE	2	enzymatic study, affinity chromatography technology	Heilker R (1999), Zhou AY (2013)	2
TRIM32	2	UBE2E1	1	two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology, pull down	Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Locke M (2009), Albor A (2006)	5
TRIM27	2	PRAM1	4	affinity chromatography technology, two hybrid, two hybrid	Cao T (1998), Cao T (1998), Rolland T (2014)	3
UBE2N	1	CHUK	5	enzymatic study	Deng L (2000)	1
TRIM32	2	TRIM23	3	two hybrid	Reymond A (2001)	1
ZNF621	0	TRIM27	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NOD2	1	TRIM27	2	affinity chromatography technology, affinity chromatography technology	Zurek B (2012), Zurek B (2012)	2
TRIM27	2	CHUK	5	affinity chromatography technology, enzymatic study	Zha J (2006), Zha J (2006)	2
TRIM32	2	UBE2E3	0	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
PIAS4	5	HDAC1	4	pull down	Gross M (2004)	1
TP53	0	PIAS1	4	two hybrid, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, imaging technique, pull down	Gallagher WM (1999), Kahyo T (2001), Kahyo T (2001), Schmidt D (2002), Pelisch F (2010), Schmidt D (2002), Chen TC (2014), Okubo S (2004)	8
UBE2I	0	TP53	0	two hybrid, two hybrid, two hybrid, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Minty A (2000), Gallagher WM (1999), Shen Z (1996), Bernier-Villamor V (2002), Wang J (2008), Spektor TM (2011), Jakobs A (2007), Mohideen F (2009), Lin JY (2004), Bennett RL (2012), Heo KS (2013), Morimoto M (2003), Rodriguez MS (1999), Muller S (2000), Fernandez-Lloris R (2006), Mohan RD (2007), Brandt M (2013), Weger S (2005)	18
NEDD9	3	TRIM27	2	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
IKBKB	1	CHUK	5	affinity chromatography technology, biochemical, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, enzymatic study, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, enzymatic study, enzymatic study, affinity chromatography technology, biochemical, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, affinity chromatography technology	Zandi E (1997), Chen G (2002), Otsuki T (2002), May MJ (2000), May MJ (2000), Woronicz JD (1997), Woronicz JD (1997), Deng L (2000), Yeung KC (2001), Mercurio F (1997), Mercurio F (1997), Rothwarf DM (1998), Wu ZH (2010), Li S (2011), Li S (2011), May MJ (2002), Heilker R (1999), Leotoing L (2011), McKenzie FR (2000), Zandi E (1998), Lee DF (2007), Li XH (2001), Yeh PY (2011), Yeh PY (2011), Stehlik C (2002), Li Q (2006), So J (2015), Chen TC (2014), Karim ZA (2015), Huttlin EL (2017)	30
TRIM32	2	UBE2N	1	two hybrid, affinity chromatography technology, two hybrid, two hybrid, two hybrid, two hybrid, affinity chromatography technology, affinity chromatography technology	Saccone V (2008), Saccone V (2008), van Wijk SJ (2009), Markson G (2009), Napolitano LM (2011), Napolitano LM (2011), Napolitano LM (2011), Boldt K (2016)	8
USP7	14	TRIM27	2	two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hayes SD (2012), Hein MY (2015), Zaman MM (2013), Zaman MM (2013)	4
UBE2I	0	TRIM27	2	two hybrid, affinity chromatography technology	Markson G (2009), Chu Y (2011)	2
TRIM27	2	ZC2HC1C	0	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TRIM27	2	MAGEL2	6	pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, bioid	Doyle JM (2010), Hao YH (2013), Hao YH (2013), Hao YH (2013), Wijesuriya TM (2017)	5
CHUK	5	IKBKE	2	enzymatic study	Heilker R (1999)	1
UBE2E3	0	USP7	14	affinity chromatography technology	Huttlin EL (2017)	1
TRIM32	2	PIAS4	5	imaging technique, enzymatic study	Albor A (2006), Albor A (2006)	2
MDM2	2	UBE2D2	0	pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	Iyappan S (2010), Dou H (2012), Brenkman AB (2008), Fang S (2000), Szypowska AA (2011), Okamoto K (2009), Busso CS (2009), Maguire M (2008), Sehat B (2008), Uldrijan S (2007), Yang Y (2005), Jin Y (2004), Roxburgh P (2012), Shloush J (2011), Rinaldo C (2007), Cheng Q (2009), Amson R (2011), Li X (2009), David Y (2011), Sosin AM (2012), Schumacher FR (2013), Bista M (2013), Mikawa T (2014), Lohrum MA (2001), Fang S (2001), Saville MK (2004), Rodriguez MS (1999), Auger KR (2005), Wu PY (2003), Wu H (2015), Yamauchi T (2014), Nomura K (2017), Kurokawa M (2013)	33
TRIM23	3	UBE2D4	0	pull down	Dawidziak DM (2017)	1
UBE2I	0	PIAS1	4	two hybrid, pull down, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, enzymatic study, pull down, pull down	Lee BH (2003), Sapetschnig A (2002), Kahyo T (2001), Bandyopadhyay S (2010), Driscoll JJ (2010), Kahyo T (2001), Yin Y (2012), Gocke CB (2005), van den Akker E (2005), Ogawa H (2009), Schmidt D (2002), Gibbs-Seymour I (2015)	12
ZNF219	3	TRIM27	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
TRIM27	2	ABCF3	1	two hybrid, two hybrid	Rolland T (2014), Yu H (2011)	2
TRIM27	2	UBE2E1	1	two hybrid, two hybrid	Napolitano LM (2011), Napolitano LM (2011)	2
TRIM27	2	TRIM27	2	two hybrid, affinity chromatography technology, pull down, two hybrid, two hybrid	Reymond A (2001), Kato T (2009), Li X (2007), Cao T (1997), Rolland T (2014)	5
UBE2I	0	CHD4	22	enzymatic study	Gocke CB (2005)	1
USP7	14	UBE2E1	1	unspecified method, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Sarkari F (2013), Wheaton K (2017)	6
USP7	14	FBF1	2	affinity chromatography technology	Bhattacharya S (2015)	1
ZNF219	3	CHD4	22	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
USP2	0	TBK1	1	affinity chromatography technology	Zhang L (2014)	1