PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
GNAI2	1	GNAI3	0	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017)	3
EGFR	5	LYN	2	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Wu SL (2006), Wu SL (2006), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
CSK	3	RGS16	0	enzymatic study	Derrien A (2003)	1
LYN	2	RGS16	0	enzymatic study	Derrien A (2003)	1
SRC	2	EGFR	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology, two hybrid	Olayioye MA (1999), Keely SJ (2000), Sato K (2000), Lee CW (2007), Jaganathan S (2011), Jaganathan S (2011), Lee IT (2010), Hitosugi T (2007), Chang CC (2012), Chang CC (2012), Tung WH (2011), Kotlyar M (2015), Petschnigg J (2014), Li J (2013), Yao Z (2017)	15
GNAI1	10	GNA13	0	affinity chromatography technology	Huttlin EL (2015)	1
RGS16	0	GNA13	0	pull down	Johnson EN (2003)	1
RGS16	0	GNAQ	1	pull down, affinity chromatography technology	Johnson EN (2003), Johnson EN (2003)	2
GNAI1	10	GNAO1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
SRC	2	RGS16	0	enzymatic study	Derrien A (2003)	1
GNAI1	10	GNAI3	0	biochemical, affinity chromatography technology, affinity chromatography technology	Havugimana PC (2012), Huttlin EL (2015), Huttlin EL (2017)	3
SRC	2	LYN	2	unspecified method	Pirozzi G (1997)	1
EGFR	5	CSK	3	affinity chromatography technology, affinity chromatography technology, two hybrid, protein complementation assay, affinity chromatography technology	Schulze WX (2006), Tong J (2014), Kotlyar M (2015), Petschnigg J (2014), Petschnigg J (2014)	5
RGS16	0	GNAO1	21	pull down	Chen C (1997)	1
RGS16	0	GNAI1	10	enzymatic study	Wieland T (2000)	1
GNAI1	10	GNAI2	1	biochemical	Havugimana PC (2012)	1
GNAI3	0	GNAO1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
CSK	3	SRC	2	pull down	Sabe H (1994)	1
RGS16	0	EGFR	5	affinity chromatography technology, affinity chromatography technology, enzymatic study	Derrien A (2001), Derrien A (2001), Derrien A (2001)	3
RGS16	0	GDE1	1	two hybrid, pull down	Zheng B (2000), Zheng B (2000)	2
RGS16	0	GNAI2	1	pull down	Chen C (1997)	1
RGS16	0	ST14	2	two hybrid	Wang J (2011)	1
RGS16	0	GNAI3	0	pull down, affinity chromatography technology	Chen C (1997), Beadling C (1999)	2
CREB3L2	0	RGS16	0	two hybrid	Wang J (2011)	1
GNAI2	1	GNAO1	21	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ZFP36	2	RGS16	0	affinity chromatography technology	Kang JG (2011)	1