PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CSNK2A2	1	CSNK2A1	15	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), So J (2015), Huttlin EL (2015), Wan C (2015), Gao Z (2014), Hein MY (2015), Huttlin EL (2017), Hauri S (2016), Hauri S (2016)	9
FAM90A1	1	BRD2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
ELAVL1	0	BRD2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
CSNK2A2	1	CDC5L	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Huttlin EL (2015), Huttlin EL (2017)	3
OBSL1	9	BRD2	2	affinity chromatography technology	Hanson D (2014)	1
CSNK2A1	15	PIP4K2A	0	biochemical	Wan C (2015)	1
HIST1H3A	3	BRD2	2	bioid	Lambert JP (2015)	1
INO80B	0	POLR2B	3	affinity chromatography technology	Cloutier P (2017)	1
FAM90A1	1	BRD4	8	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
BRPF1	8	HIST1H3A	3	x-ray crystallography	Vezzoli A (2010)	1
BRD4	8	SPOP	1	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology	Dai X (2017), Dai X (2017), Dai X (2017), Dai X (2017), Zhang P (2017), Zhang P (2017), Zhang P (2017), Zhang P (2017)	8
DENND2D	2	BRD2	2	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
HIST2H2BE	1	BRD2	2	unspecified method, fluorescent resonance energy transfe	Kanno T (2004), Kanno T (2004)	2
PIP4K2A	0	BRD2	2	affinity chromatography technology	Huttlin EL (2017)	1
BRD2	2	TADA3	0	affinity chromatography technology	Hein MY (2015)	1
BRD2	2	E2F1	0	biochemical, affinity chromatography technology, affinity chromatography technology	Denis GV (2000), Peng J (2007), Peng J (2007)	3
OBSL1	9	CDC5L	2	affinity chromatography technology	Hanson D (2014)	1
CDC5L	2	BRD4	8	affinity chromatography technology	Lleres D (2010)	1
OBSL1	9	CSNK2A1	15	affinity chromatography technology	Hanson D (2014)	1
MDK	0	EPB41L5	0	affinity chromatography technology	Huttlin EL (2017)	1
BRD4	8	NSD3	6	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology	Rahman S (2011), Rahman S (2011), Rahman S (2011), Rahman S (2011), French CA (2014), French CA (2014), Shen C (2015), Shen C (2015), Shen C (2015), Shen C (2015)	10
CAMKV	2	EPB41L5	0	affinity chromatography technology	Huttlin EL (2017)	1
OBSL1	9	CSNK2B	5	affinity chromatography technology	Hanson D (2014)	1
ELAVL1	0	JARID2	7	affinity chromatography technology	Abdelmohsen K (2009)	1
BRD2	2	PWWP2B	0	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	CSNK2A1	15	affinity chromatography technology	Abdelmohsen K (2009)	1
BRD2	2	TBP	0	pull down, affinity chromatography technology	Peng J (2007), Peng J (2007)	2
ELAVL1	0	TERF2	2	affinity chromatography technology	Abdelmohsen K (2009)	1
BRD3	6	RUVBL2	4	biochemical	Wan C (2015)	1
8339	0	NSD3	6	bioid	Lambert JP (2015)	1
E2F2	0	E2F1	0	imaging technique	Chen TC (2014)	1
BRD2	2	POLR2B	3	affinity chromatography technology	Hein MY (2015)	1
OBSL1	9	HIST1H4A	0	affinity chromatography technology	Hanson D (2014)	1
RUVBL2	4	POLR2B	3	affinity chromatography technology, affinity chromatography technology	Jeronimo C (2007), Cloutier P (2017)	2
BAG1	1	AR	3	pull down, pull down, affinity chromatography technology	Shatkina L (2003), Knee DA (2001), Froesch BA (1998)	3
HIST1H3A	3	BRD4	8	affinity chromatography technology, fluorescent resonance energy transfe, affinity chromatography technology	Zippo A (2009), Zippo A (2009), Zippo A (2009)	3
PES1	3	BRD2	2	affinity chromatography technology	Huttlin EL (2017)	1
TERF2	2	CSNK2A2	1	affinity chromatography technology	Giannone RJ (2010)	1
AR	3	E2F1	0	affinity chromatography technology, affinity chromatography technology	Li Y (2012), Li Y (2012)	2
ERG	1	BRD2	2	affinity chromatography technology	Dai X (2017)	1
OBSL1	9	POLR2B	3	affinity chromatography technology	Hanson D (2014)	1
ERG	1	AR	3	affinity chromatography technology, affinity chromatography technology	Yu J (2010), Grasso CS (2012)	2
BRD4	8	ERG	1	affinity chromatography technology, affinity chromatography technology	Dai X (2017), Dai X (2017)	2
BRD2	2	NSD3	6	affinity chromatography technology	Hein MY (2015)	1
BRD2	2	BRPF1	8	affinity chromatography technology	Hein MY (2015)	1
PIP4K2A	0	BRD3	6	affinity chromatography technology	Huttlin EL (2017)	1
E2F1	0	TBP	0	affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology	Peng J (2007), Hagemeier C (1993), Hagemeier C (1993), Pearson A (1997), Pearson A (1997)	5
CDC5L	2	RUVBL2	4	affinity chromatography technology	Lleres D (2010)	1
CSNK2A1	15	CSNK2B	5	pull down, affinity chromatography technology, far western blotting, two hybrid, two hybrid, two hybrid, pull down, enzymatic study, affinity chromatography technology, two hybrid, enzymatic study, biochemical, far western blotting, far western blotting, x-ray crystallography, enzymatic study, two hybrid, affinity chromatography technology, two hybrid, biochemical, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology	Kim MS (1998), Kim MS (1998), Marin O (1997), Bosc DG (2000), Ahn BH (2001), Kusk M (1999), Benitez MJ (2001), Uhle S (2003), Olsen BB (2008), Son MY (1999), Son MY (1999), Havugimana PC (2012), Llorens F (2003), Llorens F (2003), Niefind K (2001), Lee NY (2009), Wang J (2011), So J (2015), Wallach T (2013), Wan C (2015), Gao Z (2014), Ren K (2011), Goetz C (1999), Hauri S (2016)	24
CAMKV	2	BRD4	8	affinity chromatography technology	Huttlin EL (2017)	1
BRD2	2	CSNK2A1	15	affinity chromatography technology	Hein MY (2015)	1
CDC14B	1	PES1	3	bioid	St-Denis N (2016)	1
HIST1H3A	3	BRD3	6	bioid	Lambert JP (2015)	1
ERG	1	ELAVL1	0	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
BRD2	2	BRD2	2	x-ray crystallography, affinity chromatography technology	Nakamura Y (2007), Nakamura Y (2007)	2
OBSL1	9	HIST2H2BE	1	affinity chromatography technology	Hanson D (2014)	1
CDC5L	2	BRD7	2	affinity chromatography technology	Lleres D (2010)	1
CSNK2A2	1	PIP4K2A	0	affinity chromatography technology	Varjosalo M (2013)	1
OBSL1	9	TAGLN2	0	affinity chromatography technology	Hanson D (2014)	1
BRD4	8	BRD2	2	affinity chromatography technology	Rahman S (2011)	1
FAM90A1	1	BRD3	6	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
NSD3	6	HIST1H4A	0	enzymatic study	Morishita M (2014)	1
EPB41L5	0	BRD2	2	affinity chromatography technology	Huttlin EL (2017)	1
INO80B	0	BRD4	8	affinity chromatography technology	Cloutier P (2017)	1
CAMKV	2	BRD3	6	affinity chromatography technology	Huttlin EL (2017)	1
AR	3	BRD3	6	affinity chromatography technology	Dai X (2017)	1
RUVBL2	4	BRD2	2	biochemical	Wan C (2015)	1
HIST1H3A	3	HIST1H4A	0	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique, affinity chromatography technology, pull down	Tagami H (2004), Shiio Y (2003), Zippo A (2009), Soldi M (2013), Klement K (2014), Sato K (2012)	6
BRD3	6	BRD2	2	affinity chromatography technology	Huttlin EL (2017)	1
OBSL1	9	PES1	3	affinity chromatography technology	Hanson D (2014)	1
RUVBL2	4	INO80B	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cai Y (2007), Cai Y (2007), Huttlin EL (2017), Cloutier P (2017)	4
ELAVL1	0	BRD4	8	affinity chromatography technology	Abdelmohsen K (2009)	1
BRD2	2	BRD7	2	affinity chromatography technology, affinity chromatography technology	Zhou M (2006), Zhou M (2006)	2
ERG	1	BRD3	6	affinity chromatography technology	Dai X (2017)	1
TADA3	0	AR	3	pull down	Li CW (2010)	1
BRD2	2	COX5A	0	affinity chromatography technology	Hein MY (2015)	1
SPOP	1	BRD2	2	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Dai X (2017), Dai X (2017), Zhang P (2017), Zhang P (2017), Zhang P (2017)	5
BRD2	2	BAG1	1	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	FARP1	1	affinity chromatography technology	Abdelmohsen K (2009)	1
PIP4K2A	0	BRPF1	8	affinity chromatography technology	Huttlin EL (2017)	1
BRD2	2	FARP1	1	affinity chromatography technology	Hein MY (2015)	1
8339	0	TERF2	2	bioid	Lambert JP (2015)	1
ELAVL1	0	E2F2	0	affinity chromatography technology	Abdelmohsen K (2009)	1
JARID2	7	BRD2	2	affinity chromatography technology	Hauri S (2016)	1
CDC14B	1	CSNK2A1	15	bioid	St-Denis N (2016)	1
INO80B	0	BRD3	6	affinity chromatography technology	Cloutier P (2017)	1
INO80B	0	BRD2	2	affinity chromatography technology	Cloutier P (2017)	1
SPOP	1	BRD3	6	affinity chromatography technology, pull down, two hybrid, affinity chromatography technology, affinity chromatography technology	Dai X (2017), Dai X (2017), Zhang P (2017), Zhang P (2017), Zhang P (2017)	5
CDC5L	2	ELAVL1	0	affinity chromatography technology	Lleres D (2010)	1
CSNK2A2	1	BRD2	2	affinity chromatography technology, affinity chromatography technology	Varjosalo M (2013), Hein MY (2015)	2
BRD4	8	AR	3	affinity chromatography technology, affinity chromatography technology	Dai X (2017), Dai X (2017)	2
CDC14B	1	BRD3	6	bioid	St-Denis N (2016)	1
CSNK2B	5	CSNK2A2	1	two hybrid, affinity chromatography technology, far western blotting, two hybrid, enzymatic study, biochemical, two hybrid, biochemical, affinity chromatography technology, two hybrid, affinity chromatography technology, enzymatic study, affinity chromatography technology	Lehner B (2004), Kim MS (1998), Marin O (1997), Bosc DG (2000), Watabe M (2011), Havugimana PC (2012), Wang J (2011), Kristensen AR (2012), Varjosalo M (2013), Wallach T (2013), Hein MY (2015), Goetz C (1999), Hauri S (2016)	13
TERF2	2	CSNK2B	5	affinity chromatography technology	Giannone RJ (2010)	1
ERG	1	SPOP	1	affinity chromatography technology, pull down, affinity chromatography technology, enzymatic study, affinity chromatography technology, affinity chromatography technology, enzymatic study, pull down	Gan W (2015), Gan W (2015), Gan W (2015), Gan W (2015), An J (2015), An J (2015), An J (2015), An J (2015)	8
CDC14B	1	BRD2	2	bioid	St-Denis N (2016)	1
TERF2	2	BRD2	2	affinity chromatography technology	Giannone RJ (2010)	1
RUVBL2	4	TBP	0	pull down	Bauer A (2000)	1
8339	0	TAGLN2	0	bioid	Lambert JP (2015)	1
CSNK2B	5	PIP4K2A	0	biochemical	Wan C (2015)	1
BRD2	2	CSNK2B	5	affinity chromatography technology	Hein MY (2015)	1
AR	3	SPOP	1	two hybrid, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	van de Wijngaart DJ (2009), An J (2014), An J (2014), An J (2014), Geng C (2014), Geng C (2014), Geng C (2014)	7
CAMKV	2	BRD2	2	affinity chromatography technology	Huttlin EL (2017)	1
8339	0	BRD2	2	bioid	Lambert JP (2015)	1
ELAVL1	0	TBP	0	affinity chromatography technology	Abdelmohsen K (2009)	1
DENND2D	2	EPB41L5	0	affinity chromatography technology, affinity chromatography technology	Huttlin EL (2015), Huttlin EL (2017)	2
PES1	3	CSNK2A1	15	affinity chromatography technology	Huttlin EL (2017)	1
OBSL1	9	ELAVL1	0	affinity chromatography technology	Hanson D (2014)	1
CDC5L	2	BRD2	2	affinity chromatography technology	Lleres D (2010)	1
BRD2	2	HIST1H4A	0	pull down, affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, unspecified method, fluorescent resonance energy transfe	Nakamura Y (2007), Kanno T (2004), Kanno T (2004), Kanno T (2004), Kanno T (2004), Zippo A (2009)	6
CDC14B	1	NSD3	6	bioid	St-Denis N (2016)	1
BRD2	2	EPB41L1	4	affinity chromatography technology	Hein MY (2015)	1
BRD4	8	HIST1H4A	0	fluorescent resonance energy transfe, affinity chromatography technology	Zippo A (2009), Zippo A (2009)	2
NSD3	6	HIST1H3A	3	enzymatic study, pull down	Morishita M (2014), Sankaran SM (2016)	2
BRD4	8	BRD3	6	affinity chromatography technology, biochemical	Rahman S (2011), Wan C (2015)	2
AR	3	TBP	0	pull down	McEwan IJ (1997)	1
8339	0	BRD3	6	bioid	Lambert JP (2015)	1
PIP4K2A	0	EPB41L5	0	affinity chromatography technology	Huttlin EL (2017)	1
MDK	0	BRD2	2	affinity chromatography technology	Huttlin EL (2017)	1
ELAVL1	0	EPB41L1	4	affinity chromatography technology	Abdelmohsen K (2009)	1
PIP4K2A	0	BRD4	8	affinity chromatography technology	Huttlin EL (2017)	1
HIST1H4A	0	HIST2H2BE	1	pull down	Shiio Y (2003)	1
BRD2	2	E2F2	0	affinity chromatography technology, biochemical	Crowley TE (2002), Denis GV (2000)	2
ERG	1	CDC5L	2	affinity chromatography technology, pull down	Wang S (2014), Wang S (2014)	2
BRD2	2	TAGLN2	0	affinity chromatography technology	Hein MY (2015)	1
ELAVL1	0	BRD3	6	affinity chromatography technology	Abdelmohsen K (2009)	1
OBSL1	9	RUVBL2	4	affinity chromatography technology	Hanson D (2014)	1
AR	3	BRD2	2	affinity chromatography technology	Dai X (2017)	1