PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
USP11	3	SUMO2	0	enzymatic study	Hendriks IA (2015)	1
UBE2D2	0	RNF4	1	two hybrid, two hybrid, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Tatham MH (2013), Erker Y (2013), Banka PA (2015), DiBello A (2016)	6
SP1	0	TBP	0	two hybrid, two hybrid, pull down, pull down	Loregian A (2003), Loregian A (2003), Schwarzenbach H (2014), Schwarzenbach H (2014)	4
UBE2I	0	TAB2	5	enzymatic study	Wang X (2014)	1
RNF4	1	HNF4A	2	enzymatic study	Zhou W (2012)	1
TAB3	1	UBC	7	x-ray crystallography, pull down, pull down, pull down	Sato Y (2009), Kanayama A (2004), Wang J (2015), Zhang X (2017)	4
USP11	3	UBC	7	enzymatic study, pull down, pull down	Faesen AC (2011), Zhang X (2017), Kwasna D (2018)	3
MAP3K7	2	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, two hybrid, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Takaesu G (2000), Takaesu G (2001), Ishitani T (2003), Ishitani T (2003), Ea CK (2006), Broglie P (2010), Liu XY (2008), Li S (2011), Li S (2011), Jiang Z (2003), Mendoza H (2008), Ear T (2010), Criollo A (2011), Kim SY (2012), Jiang Z (2002), Jiang Z (2002), Hong S (2007), Shibuya H (1996), Minoda Y (2009), Li M (2010), Scholz R (2010), Kim SI (2009), Yong Kim S (2013), Liu R (2014), Wang J (2015), Moon G (2015), Wade EM (2016), Min Y (2016), Zhang J (2017)	31
MAP3K7	2	SKIL	3	affinity chromatography technology	Kajino T (2007)	1
HNRNPL	3	UBE2E3	0	affinity chromatography technology	Fei T (2017)	1
RNF4	1	PATZ1	1	two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Fedele M (2000), Fedele M (2000), Fedele M (2000), Pero R (2002), Pero R (2002)	5
TRIM28	1	UBE2E1	1	pull down	Doyle JM (2010)	1
TRIM25	5	MYC	2	affinity chromatography technology	Choudhury NR (2017)	1
RNF4	1	PML	7	affinity chromatography technology, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, fluorescent resonance energy transfe, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, protein complementation assay	Bruderer R (2011), Haekli M (2005), Percherancier Y (2009), Tatham MH (2008), Maroui MA (2012), Maroui MA (2012), Li YJ (2012), Kuo CY (2014), Kuo CY (2014), Weisshaar SR (2008), Sahin U (2014)	11
SP1	0	HNF4A	2	affinity chromatography technology, affinity chromatography technology, pull down	Wang HY (2009), Wang HY (2009), Magenheim J (2005)	3
SRPK2	1	UBE2E2	1	enzymatic study	Varjosalo M (2013)	1
RPA1	0	APEX1	1	affinity chromatography technology	Marechal A (2014)	1
UBE2D1	0	UBE2B	3	biochemical	Havugimana PC (2012)	1
SKIL	3	PML	7	affinity chromatography technology	Pan D (2009)	1
PATZ1	1	AR	3	affinity chromatography technology, affinity chromatography technology	Pero R (2002), Pero R (2002)	2
CTNNB1	30	SP1	0	affinity chromatography technology	Ponce E (2014)	1
TDG	0	FANCA	5	affinity chromatography technology	Karras GI (2017)	1
APEX1	1	UBE2I	0	two hybrid	Yan MD (2002)	1
PML	7	SP1	0	affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, enzymatic study	Vallian S (1998), Vallian S (1998), Chuang YS (2011), Li J (2014), Li J (2014)	5
TAB2	5	IKBKG	0	affinity chromatography technology, two hybrid, pull down, pull down	Suzuki S (2007), Wang J (2011), Emmerich CH (2013), Emmerich CH (2013)	4
RNF4	1	UBE2B	3	pull down	DiBello A (2016)	1
MYC	2	TBP	0	pull down	McEwan IJ (1996)	1
SKIL	3	ESR1	0	affinity chromatography technology, pull down	Band AM (2011), Band AM (2011)	2
RNF4	1	TRPS1	5	affinity chromatography technology	Kaiser FJ (2003)	1
TRAIP	0	UBE2D2	0	pull down	Besse A (2007)	1
ESR1	0	SRPK2	1	affinity chromatography technology	Tarallo R (2011)	1
SP1	0	AR	3	affinity chromatography technology, affinity chromatography technology	Yuan H (2005), Chen PH (2008)	2
RPA1	0	HNRNPL	3	affinity chromatography technology	Marechal A (2014)	1
TCF20	18	RNF4	1	two hybrid, pull down	Lyngso C (2000), Lyngso C (2000)	2
TRIM25	5	CTNNB1	30	affinity chromatography technology	Choudhury NR (2017)	1
UBE2D2	0	TRIM25	5	two hybrid, pull down, pull down, pull down, affinity chromatography technology	Markson G (2009), Nakajima A (2007), Ronchi VP (2012), Sanchez JG (2016), Choudhury NR (2017)	5
RNF4	1	UBE2A	0	pull down	DiBello A (2016)	1
SP1	0	ESR1	0	imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, imaging technique, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down	Koslowski M (2009), Jin W (2008), Dong J (2006), Dong J (2006), Castet A (2006), He S (2005), He S (2005), Varshochi R (2005), Varshochi R (2005), Petz LN (2004), Li D (2007), Itoh Y (2007), Saville B (2000), Gibson LL (2005)	14
RPA1	0	TARDBP	4	affinity chromatography technology	Marechal A (2014)	1
TRAIP	0	MAP3K7	2	affinity chromatography technology	Kong QZ (2016)	1
RNF4	1	TRAIP	0	two hybrid	Woodsmith J (2012)	1
SKIL	3	RNF4	1	two hybrid	Colland F (2004)	1
AR	3	NCOA1	6	two hybrid, pull down, two hybrid, affinity chromatography technology, two hybrid, two hybrid, pull down, two hybrid	Masiello D (2004), Bevan CL (1999), Bevan CL (1999), Ueda T (2002), Needham M (2000), Wolf SS (2007), Wolf SS (2007), Chan CM (2013)	8
TRIM25	5	TDG	0	affinity chromatography technology	Choudhury NR (2017)	1
UBE2E2	1	RNF4	1	two hybrid, pull down	Markson G (2009), Banka PA (2015)	2
SUMO2	0	UBE2I	0	affinity chromatography technology, pull down, two hybrid, two hybrid, pull down, pull down, enzymatic study, enzymatic study, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology, affinity chromatography technology	Li T (2006), Knipscheer P (2007), Boutell C (2011), Hecker CM (2006), Hecker CM (2006), Zilio N (2013), Tatham MH (2001), Knipscheer P (2007), Ullmann R (2012), Matic I (2008), Xu Y (2014), Wan C (2015), Hein MY (2015), Huttlin EL (2017)	14
RPA1	0	TRIM28	1	affinity chromatography technology	Marechal A (2014)	1
ESR1	0	PATZ1	1	affinity chromatography technology	Okada M (2015)	1
UBE2K	0	UBC	7	enzymatic study, x-ray crystallography, x-ray crystallography, pull down, enzymatic study, enzymatic study, pull down, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, enzymatic study	Flierman D (2006), Ko S (2010), Wilson RC (2011), Wilson RC (2011), Wilson RC (2011), Sheng Y (2012), Raasi S (2005), Bishop N (2002), Rajsbaum R (2014), Chong RA (2014), Whitby FG (1998), Singh RK (2012), Cook BW (2015)	13
UBE2E3	0	UBC	7	enzymatic study	Sheng Y (2012)	1
UBE2A	0	UBE2B	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hong JH (2015), Hong JH (2015), Huttlin EL (2017)	3
AR	3	UBE2I	0	two hybrid, affinity chromatography technology, genetic interference, enzymatic study	Poukka H (1999), Poukka H (1999), Poukka H (1999), Ogawa H (2009)	4
PML	7	TDG	0	affinity chromatography technology, pull down, imaging technique	Takahashi H (2005), Takahashi H (2005), Mohan RD (2007)	3
TERF2	2	APEX1	1	two hybrid	Lee OH (2011)	1
TAB3	1	RNF4	1	affinity chromatography technology	Tan B (2015)	1
RNF4	1	TDG	0	affinity chromatography technology, affinity chromatography technology	Hu XV (2010), Hu XV (2010)	2
NFE2L2	1	SUMO1	0	fluorescent resonance energy transfe	Malloy MT (2013)	1
UBC	7	UBE2T	0	affinity chromatography technology, affinity chromatography technology	Matsumoto M (2005), Bish RA (2007)	2
TARDBP	4	SART1	3	affinity chromatography technology	Freibaum BD (2010)	1
UBE2D4	0	TRIM25	5	two hybrid	Markson G (2009)	1
UBE2K	0	TRAIP	0	two hybrid	Markson G (2009)	1
TRIM28	1	UBE2N	1	pull down	Doyle JM (2010)	1
UBC	7	HNRNPL	3	affinity chromatography technology	Matsumoto M (2005)	1
UBE2I	0	UBE2E1	1	biochemical	Wan C (2015)	1
PGR	1	NCOA1	6	two hybrid, affinity chromatography technology, affinity chromatography technology, imaging technique, affinity chromatography technology, two hybrid	Chauchereau A (2003), Amazit L (2011), Amazit L (2011), Amazit L (2011), An BS (2006), Chauchereau A (2000)	6
ESR1	0	NCOA1	6	pull down, pull down, pull down, pull down, two hybrid, pull down, affinity chromatography technology, pull down, fluorescent resonance energy transfe, pull down, pull down, two hybrid, pull down, two hybrid, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, two hybrid, pull down, two hybrid, pull down, pull down, two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology	DiRenzo J (2000), Sheppard HM (2001), Kalkhoven E (1998), Kang YK (2002), Dutertre M (2003), Dutertre M (2003), Shiozawa T (2003), Tremblay A (2001), Llopis J (2000), Chien PY (1999), Webb P (1998), Webb P (1998), Lazennec G (1997), Heery DM (1997), Heery DM (1997), Torchia J (1997), Torchia J (1997), Fleming FJ (2004), Fujita T (2003), Fujita T (2003), Monroe DG (2003), Bai Y (2003), Bramlett KS (2001), Kraichely DM (2000), Kraichely DM (2000), Gong EY (2010), Eng FC (1998), Needham M (2000), Needham M (2000), Chan CM (2013), Kim HJ (1999), Flajollet S (2007), Albers M (2005), Kurtev V (2004), DiRenzo J (1997), Han SJ (2016), Han SJ (2016)	37
HNRNPL	3	RNF4	1	affinity chromatography technology	Fei T (2017)	1
RNF4	1	TBP	0	pull down, genetic interference	Moilanen AM (1998), Saville B (2002)	2
UBC	7	UBE2B	3	affinity chromatography technology, affinity chromatography technology	Bish RA (2007), Hong JH (2015)	2
FANCA	5	RPA1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Meetei AR (2003), Meetei AR (2003), Meetei AR (2003), Meetei AR (2003), Yan Z (2012)	5
UBC	7	SUMO1	0	affinity chromatography technology	Sahin U (2014)	1
RNF4	1	NCOA1	6	genetic interference	Saville B (2002)	1
UBE2I	0	PML	7	enzymatic study, pull down, enzymatic study, two hybrid, two hybrid, enzymatic study, enzymatic study, enzymatic study, enzymatic study, affinity chromatography technology, pull down	Knipscheer P (2008), Kim YE (2005), Satow R (2012), Duprez E (1999), Wang J (2011), Tatham MH (2003), Duprez E (1999), Gocke CB (2005), Lin DY (2006), Jo S (2016), Schilling EM (2017)	11
PGR	1	SP1	0	affinity chromatography technology, affinity chromatography technology	Faivre EJ (2008), Proietti CJ (2011)	2
HNF4A	2	TBP	0	pull down	Green VJ (1998)	1
TRIM25	5	TCF20	18	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPL	3	APEX1	1	pull down	Kuninger DT (2002)	1
ESR1	0	MYC	2	affinity chromatography technology	Cheng AS (2006)	1
ATXN1	2	UBE2E3	0	two hybrid	Lim J (2006)	1
TERF2	2	MECP2	36	affinity chromatography technology	Giannone RJ (2010)	1
ATXN1	2	UBE2I	0	two hybrid	Lim J (2006)	1
UBE2D1	0	TRIM25	5	two hybrid, pull down, pull down, pull down, pull down	Markson G (2009), Gack MU (2007), Wang Y (2014), Ronchi VP (2012), Wang S (2016)	5
TRIM28	1	UBE2D3	1	pull down	Doyle JM (2010)	1
UBE2I	0	SART1	3	enzymatic study	Vertegaal AC (2004)	1
UBE2E1	1	RNF4	1	two hybrid, pull down	Markson G (2009), Banka PA (2015)	2
ESR1	0	TDG	0	pull down, pull down, affinity chromatography technology	Chen D (2003), Chen D (2003), Chen D (2003)	3
SUMO2	0	TRIM28	1	pull down	Ouyang J (2009)	1
MYC	2	UBE2I	0	genetic interference	Toyoshima M (2012)	1
UBE2W	0	RNF4	1	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Tatham MH (2013)	3
USP11	3	PML	7	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study	Wu HC (2014), Wu HC (2014), Wu HC (2014), Wu HC (2014)	4
MAP3K7	2	IKBKG	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Neil JR (2009), Yang Y (2011), Wu X (2007), Emmerich CH (2013)	4
TRPS1	5	SUMO1	0	two hybrid	Kaiser FJ (2007)	1
TRIM28	1	UBE2D2	0	pull down	Doyle JM (2010)	1
UBC	7	UBE2D3	1	affinity chromatography technology, two hybrid, x-ray crystallography, pull down, pull down, pull down	Matsumoto M (2005), Vinayagam A (2011), Pruneda JN (2014), Li Y (2014), Poyurovsky MV (2007), Zhang X (2017)	6
AR	3	RNF4	1	two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Moilanen AM (1998), Poukka H (2000), Moilanen AM (1998), Moilanen AM (1998), Pero R (2002), Pero R (2002), Poukka H (2000)	7
UBC	7	MAP3K7	2	pull down	Zhang X (2017)	1
RNF4	1	SUMO2	0	fluorescent resonance energy transfe, affinity chromatography technology, pull down, enzymatic study, pull down, enzymatic study, enzymatic study, pull down, x-ray crystallography, pull down, enzymatic study, pull down, pull down, pull down, affinity chromatography technology, enzymatic study	Geoffroy MC (2010), Bruderer R (2011), Bruderer R (2011), Tatham MH (2008), Sun H (2012), Tatham MH (2013), Erker Y (2013), Keusekotten K (2014), Kung CC (2014), Kung CC (2014), Xu Y (2014), Yin Y (2012), Tatham MH (2008), Xu Y (2014), Ouyang J (2015), Lecona E (2016)	16
HNF4A	2	NCOA1	6	two hybrid	Wang JC (1998)	1
UBE2K	0	UBE2N	1	biochemical	Wan C (2015)	1
TRIM25	5	RPA1	0	affinity chromatography technology	Pauli EK (2014)	1
RNF4	1	PGR	1	two hybrid	Moilanen AM (1998)	1
TAB2	5	UBC	7	pull down, x-ray crystallography, x-ray crystallography, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down	Kulathu Y (2009), Kulathu Y (2009), Sato Y (2009), van Wijk SJ (2012), Kanayama A (2004), Niu J (2011), van Wijk SJ (2013), Hooper C (2014), Komander D (2009), Emmerich CH (2013), Wauer T (2015), Kristariyanto YA (2015), Zhang X (2017)	13
UBC	7	TRIM28	1	affinity chromatography technology, enzymatic study	Matsumoto M (2005), Doyle JM (2010)	2
UBE2I	0	TDG	0	enzymatic study, enzymatic study, enzymatic study	Knipscheer P (2008), Mohan RD (2007), Coey CT (2014)	3
RNF4	1	TARDBP	4	imaging technique	Guo L (2014)	1
TRIM25	5	USP11	3	affinity chromatography technology	Choudhury NR (2017)	1
PML	7	SUMO1	0	two hybrid, imaging technique, fluorescent resonance energy transfe, two hybrid, two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, x-ray crystallography, fluorescent resonance energy transfe, unspecified method, two hybrid, pull down	Lin DY (2002), Cuchet-Lourenco D (2011), Percherancier Y (2009), Cuchet-Lourenco D (2012), Stehmeier P (2009), Duprez E (1999), Shen TH (2006), Shen TH (2006), Saether T (2007), Cappadocia L (2015), Cappadocia L (2015), Cappadocia L (2015), Li C (2017), Li C (2017)	14
RNF4	1	ESR1	0	two hybrid	Moilanen AM (1998)	1
UBE2D3	1	TRIM25	5	two hybrid, pull down, pull down, affinity chromatography technology	Markson G (2009), Ronchi VP (2012), Choudhury NR (2017), Choudhury NR (2017)	4
HNRNPL	3	TRPS1	5	affinity chromatography technology	Fei T (2017)	1
SRPK2	1	MDC1	8	enzymatic study	Lipp JJ (2015)	1
TRIM28	1	UBE2E2	1	pull down	Doyle JM (2010)	1
PML	7	CTNNB1	30	affinity chromatography technology, pull down, affinity chromatography technology	Satow R (2012), Satow R (2012), Shtutman M (2002)	3
RNF4	1	USP11	3	affinity chromatography technology	Hendriks IA (2015)	1
NCOA1	6	TBP	0	pull down	Takeshita A (1996)	1
CTNNB1	30	ESR1	0	affinity chromatography technology	Kouzmenko AP (2004)	1
UBE2H	3	RNF4	1	two hybrid	Markson G (2009)	1
UBE2H	3	TRAIP	0	two hybrid	Markson G (2009)	1
TRIM25	5	HNRNPL	3	affinity chromatography technology	Choudhury NR (2017)	1
TAB3	1	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011)	4
RNF4	1	TRIM28	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, protein complementation assay	Bruderer R (2011), Kuo CY (2014), Kuo CY (2014), Kuo CY (2014), Kuo CY (2014)	5
RPA1	0	TERF2	2	affinity chromatography technology	Marechal A (2014)	1
CTNNB1	30	HNF4A	2	affinity chromatography technology, pull down, affinity chromatography technology, imaging technique	Mulholland DJ (2003), Mulholland DJ (2003), Mulholland DJ (2003), Chen TC (2014)	4
UHRF1	3	UBE2D3	1	pull down	Zhang ZM (2015)	1
UBE2D1	0	RNF4	1	two hybrid, two hybrid, affinity chromatography technology, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Plechanovova A (2011), Plechanovova A (2011), Tatham MH (2008), Tatham MH (2013), Yang YC (2013), Groocock LM (2014), Rojas-Fernandez A (2014), Guo L (2014), Xu Y (2014), Lecona E (2016), DiBello A (2016)	13
TRIM28	1	UBE2D1	0	pull down	Doyle JM (2010)	1
UBE2D4	0	RNF4	1	two hybrid, two hybrid, pull down	van Wijk SJ (2009), Markson G (2009), Tatham MH (2013)	3
TDG	0	PGR	1	pull down	Chen D (2003)	1
UBE2D1	0	UBC	7	x-ray crystallography	Bosanac I (2010)	1
TRIM25	5	SRPK2	1	affinity chromatography technology	Choudhury NR (2017)	1
RNF4	1	MAP3K7	2	affinity chromatography technology, affinity chromatography technology	Tan B (2015), Tan B (2015)	2
UBC	7	UEVLD	3	pull down	Nathan JA (2013)	1
UBC	7	UBE2N	1	affinity chromatography technology, enzymatic study, enzymatic study, x-ray crystallography, enzymatic study, enzymatic study, affinity chromatography technology, enzymatic study, enzymatic study, enzymatic study, enzymatic study, pull down	Matsumoto M (2005), Scheper J (2010), Wu PY (2003), McKenna S (2003), Wiener R (2012), Ye Y (2003), Bish RA (2007), Juang YC (2012), Pastushok L (2007), Singh RK (2012), McKenna S (2001), McKenna S (2001)	12
UBE2E2	1	NFE2L2	1	pull down	Plafker KS (2010)	1
UBE2I	0	RNF4	1	two hybrid, two hybrid	Markson G (2009), Bandyopadhyay S (2010)	2
RNF4	1	IKBKG	0	two hybrid	Ravasi T (2010)	1
HNRNPL	3	UBE2K	0	affinity chromatography technology	Fei T (2017)	1
CTNNB1	30	AR	3	pull down, two hybrid, two hybrid, two hybrid, pull down, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Yang F (2002), Yang F (2002), Masiello D (2004), Song LN (2004), Amir AL (2003), Amir AL (2003), Mulholland DJ (2003), Mulholland DJ (2003), Pawlowski JE (2002), Mulholland DJ (2003), Levy L (2004)	11
TDG	0	AR	3	pull down	Chen D (2003)	1
TDG	0	SUMO1	0	two hybrid, pull down, two hybrid, x-ray crystallography, pull down, two hybrid, pull down, two hybrid	Minty A (2000), Hardeland U (2002), Hardeland U (2002), Smet-Nocca C (2011), Smet-Nocca C (2011), Plosky BS (2006), Mohan RD (2007), Hecker CM (2006)	8
RPA1	0	MDC1	8	affinity chromatography technology	Marechal A (2014)	1
SRPK2	1	SART1	3	enzymatic study	Lipp JJ (2015)	1
AR	3	TCF20	18	affinity chromatography technology, pull down, bioid	Elvenes J (2011), Elvenes J (2011), Lempiaeinen JK (2017)	3
ESR1	0	TAB3	1	affinity chromatography technology	Okada M (2015)	1
TRIM25	5	ESR1	0	affinity chromatography technology, pull down, enzymatic study	Nakajima A (2007), Nakajima A (2007), Nakajima A (2007)	3
UBE2I	0	UBE2K	0	enzymatic study, enzymatic study, enzymatic study, enzymatic study, biochemical	Knipscheer P (2008), Gruenwald M (2011), Pichler A (2005), Galisson F (2011), Wan C (2015)	5
TAB2	5	RNF4	1	affinity chromatography technology	Tan B (2015)	1
TRIM28	1	UHRF1	3	affinity chromatography technology, affinity chromatography technology	Quenneville S (2011), Quenneville S (2011)	2
CTNNB1	30	UBE2D1	0	pull down	Saha A (2008)	1
TRAIP	0	UBE2D1	0	pull down	Besse A (2007)	1
TRIM28	1	UBE2H	3	pull down	Doyle JM (2010)	1
PML	7	ATXN1	2	imaging technique, enzymatic study	Guo L (2014), Guo L (2014)	2
RNF4	1	MIS18BP1	6	affinity chromatography technology	Cuijpers SAG (2017)	1
TRIM25	5	SART1	3	affinity chromatography technology	Choudhury NR (2017)	1
NFE2L2	1	SUMO2	0	fluorescent resonance energy transfe	Malloy MT (2013)	1
SKIL	3	TDG	0	two hybrid	Colland F (2004)	1
ESR1	0	UBE2I	0	two hybrid, enzymatic study	Kobayashi S (2004), Sentis S (2005)	2
UBE2I	0	UBE2D2	0	biochemical	Wan C (2015)	1
ATXN1	2	SUMO1	0	two hybrid	Kang S (2010)	1
UHRF1	3	USP11	3	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Ma H (2012), Ma H (2012), Ma H (2012)	3
CTNNB1	30	UBE2B	3	affinity chromatography technology, affinity chromatography technology, pull down, pull down, enzymatic study, enzymatic study	Gerard B (2012), Gerard B (2012), Gerard B (2012), Gerard B (2012), Gerard B (2012), Shekhar MP (2008)	6
HNRNPL	3	UBE2H	3	affinity chromatography technology	Fei T (2017)	1
ATXN1	2	UBE2E1	1	two hybrid, pull down, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Hong S (2008), Hong S (2008), Hong S (2008), Hong S (2008), Hong S (2008), Kang AR (2015)	6
NFE2L2	1	TCF20	18	imaging technique	Darvekar SR (2014)	1
IKBKG	0	MYC	2	affinity chromatography technology	Kim BY (2010)	1
HNRNPL	3	ATXN1	2	affinity chromatography technology	Fei T (2017)	1
RNF4	1	CTNNB1	30	pull down	Thomas JJ (2016)	1
RPA1	0	UBC	7	affinity chromatography technology	Marechal A (2014)	1
RNF4	1	MYC	2	pull down	Thomas JJ (2016)	1
MECP2	36	HIST2H3C	0	x-ray crystallography	Yang C (2011)	1
RNF4	1	SP1	0	affinity chromatography technology, affinity chromatography technology, pull down, enzymatic study, affinity chromatography technology	Poukka H (2000), Wang YT (2011), Wang YT (2011), Wang YT (2011), Wang M (2016)	5
MYC	2	TRIM28	1	affinity chromatography technology	Koch HB (2007)	1
RNF4	1	HIST2H3C	0	enzymatic study	Groocock LM (2014)	1
SUMO2	0	TDG	0	two hybrid, pull down	Hecker CM (2006), Ouyang J (2009)	2
RNF4	1	MDC1	8	affinity chromatography technology	Yin Y (2012)	1
RNF4	1	MECP2	36	enzymatic study	Wang Y (2014)	1
UBE2D3	1	RNF4	1	two hybrid, two hybrid, pull down, pull down, pull down	van Wijk SJ (2009), Markson G (2009), Tatham MH (2013), Erker Y (2013), DiBello A (2016)	5
TBP	0	ESR1	0	pull down, pull down	Waernmark A (2001), Lazennec G (1997)	2
RNF4	1	FANCA	5	affinity chromatography technology, affinity chromatography technology	Xie J (2015), Xie J (2015)	2
SUMO2	0	MDC1	8	pull down	Ouyang J (2009)	1
MAP3K7	2	TAB3	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Cheung PC (2004), Cheung PC (2004), Ishitani T (2003), Ishitani T (2003), Li S (2011), Li S (2011), Mendoza H (2008), Criollo A (2011), Hong S (2007), Minoda Y (2009), Liu R (2014), Shinohara H (2016), Zhang J (2017)	13
UBE2D1	0	UBE2D2	0	biochemical	Havugimana PC (2012)	1
MYC	2	TDG	0	affinity chromatography technology	Hein MY (2015)	1
UBE2I	0	TBP	0	enzymatic study	Boyer-Guittaut M (2005)	1
TRAIP	0	UBE2D3	1	pull down	Besse A (2007)	1
TAB2	5	ESR1	0	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down, pull down, pull down, affinity chromatography technology, affinity chromatography technology	Cutrupi S (2012), Cutrupi S (2012), Zhu P (2006), Zhu P (2006), Reineri S (2016), Reineri S (2016), Reineri S (2016), Reineri S (2016)	8
PGR	1	ESR1	0	affinity chromatography technology, affinity chromatography technology, imaging technique	Giulianelli S (2012), Giulianelli S (2012), Giulianelli S (2012)	3
MYC	2	PML	7	affinity chromatography technology, affinity chromatography technology, pull down	Cairo S (2005), Buschbeck M (2007), Buschbeck M (2007)	3
RNF4	1	UHRF1	3	affinity chromatography technology	Bruderer R (2011)	1
UBE2L6	0	TRIM25	5	affinity chromatography technology	Urano T (2002)	1
HNRNPL	3	AR	3	affinity chromatography technology	Fei T (2017)	1
UBC	7	SUMO2	0	affinity chromatography technology	Sahin U (2014)	1
UBE2T	0	RNF4	1	two hybrid	van Wijk SJ (2009)	1
RNF4	1	TERF2	2	affinity chromatography technology, affinity chromatography technology, pull down	Her J (2015), Her J (2015), Her J (2015)	3
UBE2E3	0	RNF4	1	two hybrid, pull down	Markson G (2009), Banka PA (2015)	2
RNF4	1	SART1	3	affinity chromatography technology	Bruderer R (2011)	1
MYC	2	NFE2L2	1	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Levy S (2010), Levy S (2010), Ramani K (2012)	3
SRPK2	1	RNF4	1	enzymatic study	Varjosalo M (2013)	1
TRIM25	5	TRIM28	1	affinity chromatography technology	Choudhury NR (2017)	1
RNF4	1	UBE2N	1	pull down, x-ray crystallography	Branigan E (2015), Branigan E (2015)	2
TRIM25	5	RNF4	1	affinity chromatography technology	Choudhury NR (2017)	1
UBE2K	0	UBE2D2	0	biochemical	Wan C (2015)	1
UBE2L6	0	RNF4	1	two hybrid	van Wijk SJ (2009)	1
TARDBP	4	TRIM28	1	affinity chromatography technology	Freibaum BD (2010)	1
UBE2N	1	TRIM25	5	two hybrid, pull down, x-ray crystallography, affinity chromatography technology	Markson G (2009), Sanchez JG (2016), Sanchez JG (2016), Choudhury NR (2017)	4
UBE2A	0	UBC	7	affinity chromatography technology	Hong JH (2015)	1
UBC	7	IKBKG	0	pull down, affinity chromatography technology, affinity chromatography technology, unspecified method, pull down, x-ray crystallography, pull down, unspecified method, x-ray crystallography, affinity chromatography technology, pull down, pull down, affinity chromatography technology, pull down, pull down, x-ray crystallography, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, pull down, two hybrid, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, pull down, affinity chromatography technology, pull down, affinity chromatography technology, affinity chromatography technology, pull down	Dynek JN (2010), Dynek JN (2010), Chiaravalli J (2011), Laplantine E (2009), Hubeau M (2011), Lo YC (2009), Ikeda F (2010), Cordier F (2009), Cordier F (2009), Cordier F (2009), Renner F (2011), Fenner BJ (2009), Fenner BJ (2009), Ivins FJ (2009), Rahighi S (2009), Rahighi S (2009), Zhu G (2007), Zhu G (2007), Niu J (2011), Keusekotten K (2013), van Wijk SJ (2013), Hooper C (2014), Wagner S (2008), Saul VV (2014), Gleason CE (2011), Komander D (2009), Kensche T (2012), Skaug B (2011), Ea CK (2006), Ea CK (2006), Lo YC (2009), Laplantine E (2009), Laplantine E (2009), Emmerich CH (2013), Dubosclard V (2015), Vincendeau M (2015), Vincendeau M (2016), Zhang X (2017), Fang R (2017), Kliza K (2017), Joo D (2016), Fang R (2017), Hauenstein AV (2017)	43
UBE2D2	0	UBC	7	x-ray crystallography, x-ray crystallography, enzymatic study, pull down, pull down	Juang YC (2012), Dou H (2012), Sheng Y (2012), Buetow L (2015), Zhang X (2017)	5
UBE2I	0	TRIM28	1	affinity chromatography technology, pull down, enzymatic study, pull down	Liang Q (2011), Garvin AJ (2013), Ivanov AV (2007), Neo SH (2015)	4
RNF4	1	NFE2L2	1	affinity chromatography technology	Malloy MT (2013)	1
UBE2K	0	RNF4	1	two hybrid	Markson G (2009)	1
UEVLD	3	RNF4	1	two hybrid	Markson G (2009)	1
HNRNPL	3	UBE2E2	1	affinity chromatography technology	Fei T (2017)	1
UBE2E3	0	NFE2L2	1	pull down, affinity chromatography technology	Plafker KS (2010), Plafker KS (2010)	2
TARDBP	4	UBE2E3	0	two hybrid, affinity chromatography technology	Hans F (2014), Hans F (2014)	2
TRPS1	5	UBE2I	0	affinity chromatography technology, two hybrid, enzymatic study, enzymatic study	Kaiser FJ (2007), Kaiser FJ (2007), Kaiser FJ (2007), Brandt M (2013)	4
TAB3	1	IKBKG	0	pull down, pull down	Kanayama A (2004), Emmerich CH (2013)	2
AR	3	TBP	0	pull down	McEwan IJ (1997)	1
TRIM25	5	TARDBP	4	affinity chromatography technology	Choudhury NR (2017)	1
HNRNPL	3	SRPK2	1	affinity chromatography technology	Fei T (2017)	1
SRPK2	1	APEX1	1	enzymatic study	Varjosalo M (2013)	1
TRIM25	5	UBC	7	enzymatic study	Sanchez JG (2016)	1
RNF4	1	RNF4	1	x-ray crystallography, fluorescent resonance energy transfe, enzymatic study, enzymatic study, affinity chromatography technology, fluorescent resonance energy transfe, enzymatic study, enzymatic study, pull down	Plechanovova A (2011), Plechanovova A (2011), Haekli M (2005), Rojas-Fernandez A (2014), Rojas-Fernandez A (2014), Rojas-Fernandez A (2014), Guo L (2014), Banka PA (2015), DiBello A (2016)	9
FANCA	5	CTNNB1	30	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Dao KH (2012), Dao KH (2012), Huard CC (2014), Huard CC (2014)	4
RNF4	1	ATXN1	2	imaging technique, enzymatic study	Guo L (2014), Guo L (2014)	2
NFE2L2	1	UBC	7	affinity chromatography technology	Su C (2015)	1
UHRF1	3	PML	7	affinity chromatography technology, affinity chromatography technology	Guan D (2012), Guan D (2012)	2
SP1	0	MECP2	36	affinity chromatography technology, affinity chromatography technology	Koch C (2004), Hwang CK (2010)	2
TRIM25	5	PML	7	affinity chromatography technology	Choudhury NR (2017)	1
SP1	0	MYC	2	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, pull down	Gartel AL (2001), Liu T (2007), Gordan JD (2007), Gordan JD (2007), Koshiji M (2005), Koshiji M (2005)	6
HIST2H3C	0	UHRF1	3	affinity chromatography technology, x-ray crystallography, x-ray crystallography, unspecified method, unspecified method	Li J (2012), Arita K (2012), Nady N (2011), Nady N (2011), Rothbart SB (2012)	5
SKIL	3	UBE2I	0	two hybrid	Colland F (2004)	1
SUMO2	0	PML	7	imaging technique, two hybrid, pull down	Cuchet-Lourenco D (2011), Li C (2017), Li C (2017)	3
AR	3	HNF4A	2	imaging technique	Mulholland DJ (2003)	1
RNF4	1	RPA1	0	affinity chromatography technology	Galanty Y (2012)	1
UBE2I	0	SUMO1	0	affinity chromatography technology, pull down, two hybrid, two hybrid, fluorescent resonance energy transfe, pull down, two hybrid, two hybrid, pull down, pull down, two hybrid, pull down, fluorescent resonance energy transfe, pull down, two hybrid, pull down, pull down, enzymatic study, enzymatic study, biochemical, affinity chromatography technology	Ewing RM (2007), Tatham MH (2003), Minty A (2000), Shen Z (1996), Song Y (2011), Knipscheer P (2007), Boutell C (2011), Gong L (1997), Gong L (1997), Hemelaar J (2004), Hecker CM (2006), Hecker CM (2006), Martin SF (2008), Everett RD (2014), Rolland T (2014), Zilio N (2013), Carbia-Nagashima A (2007), Knipscheer P (2007), Matic I (2008), Wan C (2015), Hein MY (2015)	21
SUMO1	0	RNF4	1	pull down, pull down, pull down, x-ray crystallography, protein complementation assay	Haekli M (2005), Sun H (2012), Keusekotten K (2014), Kung CC (2014), Kuo CY (2014)	5
RNF4	1	APEX1	1	affinity chromatography technology, affinity chromatography technology	Hu XV (2010), Hu XV (2010)	2
UBE2I	0	TERF2	2	enzymatic study	Her J (2015)	1
NFE2L2	1	TRIM28	1	biochemical, imaging technique	Gjyshi O (2015), Gjyshi O (2015)	2
HNF4A	2	UBE2I	0	two hybrid, enzymatic study	Albers M (2005), Zhou W (2012)	2
AR	3	TAB2	5	affinity chromatography technology, affinity chromatography technology, affinity chromatography technology	Zhu P (2006), Zhu P (2006), Reineri S (2016)	3
RNF4	1	UBC	7	enzymatic study, enzymatic study	Groocock LM (2014), Branigan E (2015)	2