Gene-drug interactions (data source: DGIdb)
Gene Name Entrez ID Drug Name Chembl ID Interaction Types Sources publications
RORA 6095 CHEMBL1231592 CHEMBL1231592 agonist GuideToPharmacologyInteractions, DrugBank 17139284, 17016423, 10592235
RORA 6095 CHEMBL497834 CHEMBL497834 agonist GuideToPharmacologyInteractions
RORA 6095 MELATONIN CHEMBL45 NCI 12595746, 8702678
RORA 6095 CHOLESTEROL CHEMBL112570 agonist GuideToPharmacologyInteractions, DrugBank 17139284, 17016423, 10592235

Variant-drug associations (data source: PharmGKB)
Gene Name Variant Alleles Chemical Phenotype Category Significance Notes Sentence Publications Annotation ID
RORA rs4774388 TT interferon beta-1a efficacy yes The TT genotype was less frequent in non-responders than in responders or in healthy controls. Genotype TT is associated with increased response to interferon beta-1a in people with Multiple Sclerosis as compared to genotypes CC + CT. 31649263 1451130600
RORA rs809736 G citalopram efficacy no It was also associated with remission. Neither association was significant after correction (430,198 SNPs tested). Frequencies listed below are for responders vs. nonresponders. Authors point out the lack of placebo control. Allele G is associated with increased response to citalopram in people with Depressive Disorder, Major as compared to allele A. 19846067 981502459