PsyMuKB

PPI network (data source: BioGrid)

A gene is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the mean normalized expression(base 2 log of (TPM+1)) +1 in all brain tissue from GTEx v7 or BrainSpan data.

A protein is determined as “expressed” when its expression values are above the pre-determined cutoff, which is the normalized expression (base 10 log of iBAQ intensity) ≥0.5 in at least one brain tissue from ProteomicsDB data. Otherwise, a gene or protein is determined as either with below-cutoff expressions or no available data.

	The queried gene/protein
	The interacting partner is expressed at mRNA-level
	The interacting partner is expressed at protein-level
	The interacting partner is expressed at both mRNA and protein level
	The interacting partner is with either below-cutoff expressions or no expression data at both mRNA and protein level
	The interacting partner is hit by coding DNMs
	Physical interaction between queried gene/protein and its partner
	Physical interaction between two interacting partners

Symbol A	GeneA coding DNM count	Symbol B	GeneB coding DNM count	Interaction detection method	Publication	Evidence
CLOCK	0	RORC	4	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
CLOCK	0	CSNK2B	5	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
RORB	3	NCOA6	6	two hybrid	Albers M (2005)	1
NCOA6	6	RORC	4	two hybrid	Albers M (2005)	1
CLOCK	0	DEC1	0	two hybrid	Wallach T (2013)	1
DEC1	0	RORC	4	two hybrid	Wallach T (2013)	1
RORB	3	NRIP1	4	two hybrid	Albers M (2005)	1
FBXO7	1	RORB	3	enzymatic study	Teixeira FR (2016)	1
PSMC5	4	RORC	4	two hybrid	Albers M (2005)	1
RORB	3	PSMC4	6	two hybrid	Albers M (2005)	1
RORB	3	RORC	4	two hybrid	Wallach T (2013)	1
RORB	3	PNRC1	0	two hybrid	Albers M (2005)	1
CSNK2B	5	RORB	3	two hybrid	Wallach T (2013)	1
RORB	3	NPPA	1	two hybrid	Albers M (2005)	1
RORB	3	PSMC5	4	two hybrid	Albers M (2005)	1
UBE2I	0	CSNK2B	5	enzymatic study	Jakobs A (2007)	1
RORB	3	TNNI2	2	two hybrid	Albers M (2005)	1
RORB	3	MAP6	3	two hybrid	Albers M (2005)	1
DEC1	0	RORB	3	two hybrid	Wallach T (2013)	1
NCOA6	6	NCOA1	6	pull down, pull down, two hybrid, affinity chromatography technology	Surapureddi S (2011), Lee SK (1999), Lee SK (1999), Goo YH (2003)	4
CLOCK	0	RORB	3	two hybrid, affinity chromatography technology	Wallach T (2013), Wallach T (2013)	2
CSNK2B	5	DEC1	0	two hybrid	Wallach T (2013)	1
RORB	3	UBE2I	0	two hybrid	Albers M (2005)	1
NSD1	25	RORB	3	two hybrid	Chan CM (2013)	1
FBXO7	1	PSMC5	4	biochemical, affinity chromatography technology	Vingill S (2016), Teixeira FR (2016)	2
PSMC4	6	PSMC5	4	two hybrid, affinity chromatography technology, biochemical, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, affinity chromatography technology, biochemical, biochemical, biochemical, two hybrid, two hybrid, affinity chromatography technology	Rual JF (2005), Ewing RM (2007), Hendil KB (2009), Kaneko T (2009), Kaneko T (2009), Lee SH (2012), Lee SH (2012), Havugimana PC (2012), Kristensen AR (2012), Wan C (2015), Albers M (2005), Albers M (2005), Huttlin EL (2017)	13
RORB	3	NCOA1	6	two hybrid, two hybrid	Chan CM (2013), Albers M (2005)	2